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"Cullis will enlighten you as to why personalized medicine will be the greatest technological advance you have ever experienced.” - Rob Wright, Chief Editor, Life Science LeaderIn this persuasive and compelling book, Pieter Cullis argues that personalized medicine, also known as precision medicine, is the biggest revolution of our time. By replacing the current one-size-fits-all approach to medicine with medical treatment based on a patient’s unique molecular makeup, personalized medicine will radically change the role of doctors and patients and even the future of our species. Increasingly, instead of focusing on the treatment of chronic diseases, as they do today, doctors will focus on helping people prevent disease. The end result will be to dramatically extend and improve our lives, creating a minefield of practical and ethical issues. Written in clear, accessible language, the book explains what personalized medicine is, how it will change healthcare, and what it means for humanity’s future.

Using the latest advances in the science of movement, this book offers the unique and innovative Spinal Training method to help prevent and alleviate back pain. And in addition to strengthening your back, Spinal Training will also improve your posture, eliminate tension, reduce your stress response and diminish pain. Drawing from Pilates, yoga, physical therapy and others and based on the principles of osteopathy, biomechanics and kinesiology, this holistic approach makes it possible for effective and gentle work to be done on the areas that are the most important for reducing back pain and enhancing good posture for a healthy back. Full-color throughout with lavish and clear illustrations of the back's anatomy, this book features step-by-step photos with 80 exercise routines that meet the requirements for a healthy back. These routines can be customized with the self-assessment exercise provided. Thus the exercises can focus precisely on each person's specific needs and desired outcome. The Spinal Training method can be used by anyone, regardless of age or fitness level. Each training plan can be individually adapted to the nature of the specific pain, for any type of posture, degree of flexibility, muscle strength, or the time available to regain normal back strength. Whether the goal is to simply maintain a healthy and happy back or to reduce and eliminate pain, this books offers the right tools to make the back feel better, no matter what the condition may be.

The definitive guide to the basic principles and latest advances in Nutritional Genomics Though still in its infancy, nutritional genomics, or "nutrigenomics," has revealed much about the complex interactions between diet and genes. But it is in its potential applications that nutrigenomics promises to revolutionize the ways we manage human health and combat disease in the years ahead. Great progress already has been made in modeling "personalized" nutrition for optimal health and longevity as well as in genotype-based dietary interventions for the prevention, mitigation, or possible cure of a variety of chronic diseases and some types of cancer. Topics covered include: * Nutrients and gene expression * The role of metabolomics in individualized health * Molecular mechanisms of longevity regulation and calorie restriction * Green tea polyphenols and soy peptides in cancer prevention * Maternal nutrition and fetal gene expression * Genetic susceptibility to heterocyclic amines from cooked foods * Bioinformatics and biocomputation in nutrigenomics * The pursuit of optimal diets Written by an all-star team of experts from around the globe, this volume provides an integrated overview of the cutting-edge field of nutritional genomics. The authors and editors lead an in-depth discussion of the fundamental principles and scientific methodologies that serve as the foundation for nutritional genomics and explore important recent advances in an array of related disciplines. Each self-contained chapter builds upon its predecessor, leading the reader seamlessly from basic principles to more complex scientific findings and experimental designs. Scientific chapters are carefully balanced with those addressing the social, ethical, regulatory, and commercial implications of nutrigenomics.

The definitive guide to the basic principles and latest advances in Nutritional Genomics Though still in its infancy, nutritional genomics, or "nutrigenomics," has revealed much about the complex interactions between diet and genes. But it is in its potential applications that nutrigenomics promises to revolutionize the ways we manage human health and combat disease in the years ahead. Great progress already has been made in modeling "personalized" nutrition for optimal health and longevity as well as in genotype-based dietary interventions for the prevention, mitigation, or possible cure of a variety of chronic diseases and some types of cancer. Topics covered include: * Nutrients and gene expression * The role of metabolomics in individualized health * Molecular mechanisms of longevity regulation and calorie restriction * Green tea polyphenols and soy peptides in cancer prevention * Maternal nutrition and fetal gene expression * Genetic susceptibility to heterocyclic amines from cooked foods * Bioinformatics and biocomputation in nutrigenomics * The pursuit of optimal diets Written by an all-star team of experts from around the globe, this volume provides an integrated overview of the cutting-edge field of nutritional genomics. The authors and editors lead an in-depth discussion of the fundamental principles and scientific methodologies that serve as the foundation for nutritional genomics and explore important recent advances in an array of related disciplines. Each self-contained chapter builds upon its predecessor, leading the reader seamlessly from basic principles to more complex scientific findings and experimental designs. Scientific chapters are carefully balanced with those addressing the social, ethical, regulatory, and commercial implications of nutrigenomics.

Advances in the standardization, precision and thoroughness of psychiatric diagnosis are being supplemented with attention to personalized or ideographic descriptive approaches. This promises not only to enhance the clinician's understanding of a case but to allow a fuller and more effective use of the evolving range of therapeutic possibilities. To reflect these developments, the Section on Classification, Diagnostic Assessment and Nomenclature of the World Psychiatric Association has prepared this volume which is organized around five prominent themes in contemporary psychiatric diagnosis: -major regional perspectives - ICD-10 - comprehensive diagnosis through the multiaxial model - treatment planning and organization of health services - the role and challenges of psychiatric diagnosis in primary health care.

Advances in the standardization, precision and thoroughness of psychiatric diagnosis are being supplemented with attention to personalized or ideographic descriptive approaches. This promises not only to enhance the clinician's understanding of a case but to allow a fuller and more effective use of the evolving range of therapeutic possibilities. To reflect these developments, the Section on Classification, Diagnostic Assessment and Nomenclature of the World Psychiatric Association has prepared this volume which is organized around five prominent themes in contemporary psychiatric diagnosis: -major regional perspectives - ICD-10 - comprehensive diagnosis through the multiaxial model - treatment planning and organization of health services - the role and challenges of psychiatric diagnosis in primary health care.

Dr. Fred Hatfield, bodybuilding guru and bestselling author, brings together the latest advances in bodybuilding science in this comprehensive guide to achieving optimum gains in muscle mass and power through personalized nutrition and training programs. Based on the premise that strength is the foundation upon which you can build the ultimate physique, Hatfield presents an innovative training system, using his state-of-the-art "ABC workouts" (muscle-specific, targeted-set, and holistic-set workouts). Add the most up-to-date information available on nutrition and exercise technique to this highly personalized training system and you have a breakthrough program that guarantees explosive growth and strength--achieved naturally, without the use of drugs. Loaded with photos, training logs and charts, psychological strategies for staying motivated, tips on contest preparation, and solutions to common problems bodybuilders face, Hardcore Bodybuilding also presents methods for determining body-fat percentage and metabolic rate and reveals the truth behind many bodybuilding myths--making it a must for anyone interested in serious weight training. Frederick C. Hatfield, PhD, has written more than 50 books and hundreds of articles on sports training, fitness, bodybuilding, and nutrition, including Bodybuilding: A Scientific Approach, Power: A Scientific Approach, and Ultimate Sports Nutrition: A Scientific Approach to Peak Athletic Performance.

Personalized and continuing relationships play a central role in any society. Economists have built upon the theories of repeated games and reputations to make important advances in understanding such relationships. Repeated Games and Reputations begins with a careful development of the fundamental concepts in these theories, including the notions of a repeated game, strategy, and equilibrium. Mailath and Samuelson then present the classic folk theorem and reputation results for games of perfect and imperfect public monitoring, with the benefit of the modern analytical tools of decomposability and self-generation. They also present more recent developments, including results beyond folk theorems and recent work in games of private monitoring and alternative approaches to reputations. Repeated Games and Reputations synthesizes and unifies the vast body of work in this area, bringing the reader to the research frontier. Detailed arguments and proofs are given throughout, interwoven with examples, discussions of how the theory is to be used in the study of relationships, and economic applications. The book will be useful to those doing basic research in the theory of repeated games and reputations as well as those using these tools in more applied research.

Personalized and continuing relationships play a central role in any society. Economists have built upon the theories of repeated games and reputations to make important advances in understanding such relationships. Repeated Games and Reputations begins with a careful development of the fundamental concepts in these theories, including the notions of a repeated game, strategy, and equilibrium. Mailath and Samuelson then present the classic folk theorem and reputation results for games of perfect and imperfect public monitoring, with the benefit of the modern analytical tools of decomposability and self-generation. They also present more recent developments, including results beyond folk theorems and recent work in games of private monitoring and alternative approaches to reputations. Repeated Games and Reputations synthesizes and unifies the vast body of work in this area, bringing the reader to the research frontier. Detailed arguments and proofs are given throughout, interwoven with examples, discussions of how the theory is to be used in the study of relationships, and economic applications. The book will be useful to those doing basic research in the theory of repeated games and reputations as well as those using these tools in more applied research.