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Vinyl LP pressing. With Apoptosis, Allegaeon deliver their defining statement. A near-perfect symbiosis of technical, progressive, and melodic death metal, it's a record that's as crushingly heavy as it is inventive, lithe and intelligent, and marks a significant leap forward in their songwriting. "On this record, I was more open to new ideas that we might not have used in past," states guitarist Michael Stancel. "Rather than deleting something because 'it's not Allegaeon-y enough', I would take

These volumes present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer and neurodegenerative diseases. These comprehensive volumes integrate the most innovative and current findings from several related disciplines of scientific research, including pathology, genetics, virology, cell biology, immunology, and molecular biology.

These volumes present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer and neurodegenerative diseases. These comprehensive volumes integrate the most innovative and current findings from several related disciplines of scientific research, including pathology, genetics, virology, cell biology, immunology, and molecular biology.

A million cells in our bodies die every second--they commit suicide by activating a process called apoptosis or other forms of programmed cell death. These mechanisms are essential for survival of the body as a whole and play critical roles in various developmental processes, the immune system, and cancer.In this second edition of Douglas Green's essential book on cell death, Green retains the bottom-up approach of the first edition, starting with the enzymes that carry out the execution (caspases) and their cellular targets before examining the machinery that connects them to signals that cause cell death. He also describes the roles of cell death in development, neuronal selection, and the development of self-tolerance in the immune system, as well as how the body uses cell death to defend against cancer.The new edition is fully updated to cover the many recent advances in our understanding of the death machinery and signals that control cell death. These include the mechanisms regulating necroptosis, mitophagy, and newly identified processes, such as ferroptosis. The book will thus be of great interest to researchers actively working in the field, as well as biologists and undergraduates encountering the topic for the first time.

A million cells in our bodies die every second--they commit suicide by activating a process called apoptosis or other forms of programmed cell death. These mechanisms are essential for survival of the body as a whole and play critical roles in various developmental processes, the immune system, and cancer.In this second edition of Douglas Green's essential book on cell death, Green retains the bottom-up approach of the first edition, starting with the enzymes that carry out the execution (caspases) and their cellular targets before examining the machinery that connects them to signals that cause cell death. He also describes the roles of cell death in development, neuronal selection, and the development of self-tolerance in the immune system, as well as how the body uses cell death to defend against cancer.The new edition is fully updated to cover the many recent advances in our understanding of the death machinery and signals that control cell death. These include the mechanisms regulating necroptosis, mitophagy, and newly identified processes, such as ferroptosis. The book will thus be of great interest to researchers actively working in the field, as well as biologists and undergraduates encountering the topic for the first time.

Cell death is fast becoming one of the most dynamic areas of biological research-involving as it does the study of apoptosis and programmed cell death and the role these phenomena play in development and homeostasis on the one hand, and aging and disease on the other. The profound implications for medicine and agriculture from the manipulation of these processes have spawned a deluge of research papers, articles, approaches, and methods-making it difficult for scientists to get an overview of the field. When Cells Die II: A Comprehensive Evaluation of Apoptosis and Programmed Cell Death offers the most thorough, cutting-edge coverage of this field since publication of the acclaimed first edition. Leading international researchers present an up-to-date yet accessible survey ranging from the history of cell death science to its modern methodology. Extensively revised to include major advances in research, this new edition features relevant discussion of: * The impact of genomics and proteomics * Gene therapy and pharmacogenetics * The role of mitochondria * Caspase-independent and non-apoptotic cell death * Evolution of mechanisms With the manipulation of programmed cell death in clinical situations now in the foreseeable future, When Cells Die II also addresses the role of apoptosis in specific organ systems-the immune system, nervous system, and gastrointestinal tract-as well as different disease states, including viral infection, cancer, and myocardial infarct. Expertly edited to provide detailed cross-referencing, consistency of style, and a logical progression of topics, When Cells Die II is the definitive resource for understanding current cell death science. It will prove an invaluable text for advanced undergraduate, graduate, and medical students, postdoctoral fellows, scientists, and clinicians in cell biology, immunology, developmental biology, neuroscience, and cancer research.

Virtually every aspect of mitochondrial research and medicine is addressed in this volume, including mitochondrial function and dysfunction, free radical biology relevant to mitochondrial dysfunction, the role of mitochondria in apoptosis, and abnormal signaling processes and disease mechanisms associated with aging, mtDNA mutations, or mitochondrial damage. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's disease is an adult-onset fatal neurodegenerative disease characterised by progressive apoptosis of upper and lower motor neurons in the brain, brainstem and spinal cord. This results in paralysis of bulbar, limb, thoracic and abdominal skeletal muscles, and death within 25 years of diagnosis. In this book, the authors present current research on the symptoms, treatment and prognosis of ALS. Topics include audiological profiles and hearing loss in ALS patients; the role of the lipid transcription factor and sterol regulatory element binding protein 1 (SREBP1) in ALS; molecular targeted therapy for ALS; physical and communication disabilities in ALS; psychological interventions for ALS patients and their caregivers; and a study of ALS progression and propagation.

Virtually every aspect of mitochondrial research and medicine is addressed in this volume, including mitochondrial function and dysfunction, free radical biology relevant to mitochondrial dysfunction, the role of mitochondria in apoptosis, and abnormal signaling processes and disease mechanisms associated with aging, mtDNA mutations, or mitochondrial damage. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.

Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's disease is an adult-onset fatal neurodegenerative disease characterised by progressive apoptosis of upper and lower motor neurons in the brain, brainstem and spinal cord. This results in paralysis of bulbar, limb, thoracic and abdominal skeletal muscles, and death within 25 years of diagnosis. In this book, the authors present current research on the symptoms, treatment and prognosis of ALS. Topics include audiological profiles and hearing loss in ALS patients; the role of the lipid transcription factor and sterol regulatory element binding protein 1 (SREBP1) in ALS; molecular targeted therapy for ALS; physical and communication disabilities in ALS; psychological interventions for ALS patients and their caregivers; and a study of ALS progression and propagation.