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Membrane Transport is targeted towards researchers with an interest in the mechanism of solute transport across biological membranes. Its scope is broad, ranging from the techniques required to study transport itself, through the expression, purification and reconstitution of transporters, to techniques for investigation of their structures. As such, it not only proves the necessary technical grounding for newcomers to the field, but should also be of value to "old-hands" wishing to get up to date with recent developments in these areas. While some of the approaches described require sophisticated equipment (e.g. a stopped-flow fluorimeter), most of the protocols can be implemented in any well- found laboratory. Preparation of this volume comes at a time when a result of genome sequencing our knowledge of membrane transporter sequences is far outstripping our understanding of their molecular mechanisms. Our hope is that this book will help future researchers to redress this imbalance.

51 worldwide leading experts in the field of erythrocyte research contributed to this first book on transport processes in red blood cells. It explains the latest findings on the basis of well-established principles, in an accessibly structured and carefully organized compilation.

51 worldwide leading experts in the field of erythrocyte research contributed to this first book on transport processes in red blood cells. It explains the latest findings on the basis of well-established principles, in an accessibly structured and carefully organized compilation.

Details: Three-layer membrane The Waterproof Anorak is made with a premium three-layer membrane for complete water- and windproofing with dynamic breathability. Hydrophilic elements in the lining transport moisture from the body and expand as they work. Which means the more you sweat, the more breathable the anorak becomes. Design PTFE- and PFC free The materials responsible for the performance of the Waterproof Anorak were carefully selected to perform responsibly. The advanced waterproof membrane is not only breathable, stretchable and durable, it’s also entirely PTFE-free. What’s more, its 20,000 mm water column is backed-up by a PFC-free durable water-repellant coating. Care instructions: Machine wash 40°C gentle. Iron on low. Tumble dry on low. Do not dry clean or bleach. Specs: 100% polyamide Weight - 152g Conditions - Waterproof On Waterproof Anorak Medium Zest

Details: Three-layer membrane The Waterproof Anorak is made with a premium three-layer membrane for complete water- and windproofing with dynamic breathability. Hydrophilic elements in the lining transport moisture from the body and expand as they work. Which means the more you sweat, the more breathable the anorak becomes. Design PTFE- and PFC free The materials responsible for the performance of the Waterproof Anorak were carefully selected to perform responsibly. The advanced waterproof membrane is not only breathable, stretchable and durable, it’s also entirely PTFE-free. What’s more, its 20,000 mm water column is backed-up by a PFC-free durable water-repellant coating. Care instructions: Machine wash 40°C gentle. Iron on low. Tumble dry on low. Do not dry clean or bleach. Specs: 100% polyamide Weight - 152g Conditions - Waterproof On Waterproof Anorak XS Zest

This is a completely revised and expanded edition of the Guidebook to Biochemistry. Every chapter has been reviewed and brought up to date. A new chapter, on the cell and membrane transport, has been included, and the single chapter on regulation in the previous edition has been greatly enlarged and divided into two chapters. Other topics that have received particular attention in this edition include lipids, cell membranes and the biochemical action of hormones. The chapter on genetics has been revised to take account of recent studies of the genetic organization of higher organisms, and a section on genetic engineering has been included. In making these changes the authors have taken care to adhere to the concept of the 'Guidebook' introduced by Kenneth Harrison and maintained by them in the 1971 edition: to 'introduce the reader to the important features of the subject by exemplifying and discussing crucial biochemical concepts'. For this reason they have been careful to restrict the increase in the total length of the book compared with the 1971 edition.

Ions, their transport across membranes, and their flow through specialized ion channels are central to the understanding of brain function, normal and pathological. The first part of this book deals with the regulation of ions in brain extra- and intracellular fluids. Regulation is effected by the blood-brain barrier, and by membrane ion pumps and other transport mechanisms of neurons and glial cells. Normally adjusted for optimal neural function, ion levels can change and alter the excitability of neurons and influence synaptic transmission in healthy and diseased brains. After an introduction to the electrophysiology of epilepsy, and a description of experimental seizure "models," the second part discusses the roles of the faulty regulation of ions and of the diseases of ion channels in generating epileptic seizures. The mechanisms of action of various anticonvulsant drugs are also considered. The third part is devoted to the phenomenon of spreading depression and its likely role in human diseases. The final chapters of the book deal with the role of ions in the devastation caused by lack of oxygen and by insufficient blood flow to brain tissue, and the reasons for the exceptional vulnerability of certain classes of central neurons in hypoxia and stroke. The book will be of interest to neuroscientists, neurobiologists, neurophysiologists, neurologists, neurosurgeons, and to their students and trainees.

The World of the Cell continues the tradition of previous editions widely praised for covering some of the most difficult concepts ¿ bioenergetics, metabolism, enzyme kinetics, thermodynamics, membrane transport, cell signaling, regulatory mechanisms, transcription and translation, signal transduction, and DNA replication and recombination ¿ at the right level. A Preview of the Cell, The Chemistry of the Cell, The Macromolecules of the Cell, Cells and Organelles, Bioenergetics: The Flow of Energy in the Cell, Enzymes: The Catalysts of the Cell, Membranes: Their Structure, Function, and Chemistry, Transport Across Membranes: Overcoming the Permeability Barrier, Chemotrophic Energy Metabolism: Glycolysis and Fermentation, Chemotrophic Energy Metabolism: Aerobic Respiration, Phototrophic Energy Metabolism: Photosynthesis, Intracellular Compartments: The Endoplasmic Reticulum, Golgi Complex, Endosomes, Lysosomes, and Peroxisomes, Signal Transduction Mechanisms: I. Electrical Signals in Nerve Cells, Signal Transduction Mechanisms: II. Messengers and Receptors, Cytoskeletal Systems, Cellular Movement: Motility and Contractility, Beyond the Cell: Extracellular Structures, Cell Adhesion, and Cell Junctions, The Structural Basis of Cellular Information: DNA, Chromosomes, and the Nucleus, The Cell Cycle: DNA Replication, Mitosis, and Cancer, Sexual Reproduction: Meiosis and Genetic Recombination, Gene Expression: I. The Genetic Code and Transcription, Gene Expression: II. Protein Synthesis and Sorting, The Regulation of Gene Expression, Cancer For all readers interested in bioenergetics, metabolism, enzyme kinetics, thermodynamics, membrane transport, cell signaling, regulatory mechanisms, transcription and translation, signal transduction, and DNA replication and recombination.