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Advances in genetics research, largely, though not entirely, spawned by the Human Genome Project, have led to a broad array of new technologies that promise to revolutionize life as we have known it. Medicine and agriculture are already starting to utilize new technologies to greatly improve disease prevention and treatment and food production. Yet, these improvements often raise ethical questions that are not easy to untangle. Some have gone as far to as to argue that certain applications, such as embryonic stem cell research, threaten the very fiber of our moral compass. While the application of scientific advances to better humankind has always raised thorny ethical issues, the ethical impact of genetic advances arguably reaches a new height because the applicability of advances is exceptionally broad, deep, and potentially irreversible. To utilize such technologies could mean saving thousands of lives, but where and how do we draw the line?Here, Barash sheds light on the actual ethical concerns surrounding various types of genetic technologies, introducing readers to the competing issues at stake in the arguments about the scientific application of the new technologies available and those on the horizon. She begins by illustrating the history of genetic advances, their societal applications, and the ethical issues that have arisen from those applications. Using case studies and examples throughout, she walks readers through the various considerations involved in a variety of areas related to the application of genetic technologies currently available and possible in the future. Covering topics ranging from stem cell research to genetically modified food, genetic mapping to cloning, this book offers a thoughtful approach to the complex issues at play in the various fields of genetic technologies.

Advances in genetics research, largely, though not entirely, spawned by the Human Genome Project, have led to a broad array of new technologies that promise to revolutionize life as we have known it. Medicine and agriculture are already starting to utilize new technologies to greatly improve disease prevention and treatment and food production. Yet, these improvements often raise ethical questions that are not easy to untangle. Some have gone as far to as to argue that certain applications, such as embryonic stem cell research, threaten the very fiber of our moral compass. While the application of scientific advances to better humankind has always raised thorny ethical issues, the ethical impact of genetic advances arguably reaches a new height because the applicability of advances is exceptionally broad, deep, and potentially irreversible. To utilize such technologies could mean saving thousands of lives, but where and how do we draw the line?Here, Barash sheds light on the actual ethical concerns surrounding various types of genetic technologies, introducing readers to the competing issues at stake in the arguments about the scientific application of the new technologies available and those on the horizon. She begins by illustrating the history of genetic advances, their societal applications, and the ethical issues that have arisen from those applications. Using case studies and examples throughout, she walks readers through the various considerations involved in a variety of areas related to the application of genetic technologies currently available and possible in the future. Covering topics ranging from stem cell research to genetically modified food, genetic mapping to cloning, this book offers a thoughtful approach to the complex issues at play in the various fields of genetic technologies.

The latest edition of this highly successful textbook introduces the key techniques and concepts involved in cloning genes and in studying their expression and variation. The new edition features: Increased coverage of whole-genome sequencing technologies and enhanced treatment of bioinformatics. Clear, two-colour diagrams throughout. A dedicated website including all figures. Noted for its outstanding balance between clarity of coverage and level of detail, this book provides an excellent introduction to the fast moving world of molecular genetics.

The latest edition of this highly successful textbook introduces the key techniques and concepts involved in cloning genes and in studying their expression and variation. The new edition features: Increased coverage of whole-genome sequencing technologies and enhanced treatment of bioinformatics. Clear, two-colour diagrams throughout. A dedicated website including all figures. Noted for its outstanding balance between clarity of coverage and level of detail, this book provides an excellent introduction to the fast moving world of molecular genetics.

A biologist and a Christian theologian examine the scientific and philosophical implications and potential impacts of genetic technologies.· A series of chapters combining basic scientific discussions of DNA technologies with ethical discussions of the social issues they are raising· Five hypothetical case studies that provide realistic contexts for exploring specific issues related to genetic technologies· An extensive bibliography of current and significant books, journals and websites with regard to genetic technologies· A comprehensive index

A biologist and a Christian theologian examine the scientific and philosophical implications and potential impacts of genetic technologies.· A series of chapters combining basic scientific discussions of DNA technologies with ethical discussions of the social issues they are raising· Five hypothetical case studies that provide realistic contexts for exploring specific issues related to genetic technologies· An extensive bibliography of current and significant books, journals and websites with regard to genetic technologies· A comprehensive index

Whether you call them gods, angels, ETs, aliens, or spirit entities, sufficient proof now exists to make the case that history has been influenced by beings more advanced than humans. The evidence suggests they shaped our religions, genes, technology, and cultures. In fact, the impetus for modern civilization appears due to their intervention.Analysis of all types of reported nonhuman consciousness reveals a generic category the author calls Advanced Beings, or ABs. A review of sacred texts, myths and legends, and contemporary reports shows all such entities fit into a natural universe. It includes allegedly divine beings, heavenly hosts, guardians, ascended masters, and intelligences from other planets or other dimensions. Whether from the Pleiades or Yahweh’s Heaven, historical, archeological, and scientific evidence now shows we’ve had their help along the way.While scientists, religious leaders, and governments continue to ignore or deny it, our very identity as a species and its psychological health hang in the balance. How to deal with the effects of such contacts lies at the center of a covert struggle for control of human consciousness.Startlingly, Von Ward explains why institutions do not want to address this question. And he shows how generations have been conditioned to ignore or suppress a significant part of their experience, despite the fact that thousands daily still claim contact with a God or another AB.How did humans reach the point where leaders claim to speak for God in such conflicting ways? Paul Von Ward, also author of Our Solarian Legacy, says resolving the religious and ideological divisions that energize modern terrorism requires people, East and West, to re-examine the origins of notions like "divine revelation," "chosen people," and "a supernatural religion."

Advances in genetics have begun to deliver on their promise of new and improved approaches to the prevention and treatment of human disease, including the gene-based therapeutics. The international sports community has begun to recognize the potential harmful use of gene transfer technology by athletes. The task of monitoring and controlling sports doping must be a truly cooperative effort, involving the cooperation of a range of local, national, and international organizations. There are very serious broad social and ethical issues at stake that relate to our definition of sports and its role in our society, as well as the social and ethical principles that are challenged or breached through sport doping, determining which forms of performance enhancement – in sport or any other realm of human activity – are acceptable, and what makes the enhancement of sport performance different from enhancement in other areas of human activity (e.g., cosmetic surgery, mood and learning enhancement through drugs, and drug-based “treatment of physical and intellectual changes in normal aging process). This book tackles all these issues and more, serving as the first such focused treatment of this increasingly important topic, which has broad-based implications for science, medicine, sports, and society.

The teachings of Mies van der Rohe and his respect for the effects of space and material has had a great influence on the American architect and artist Gene Summers. Thanks to the technology of the day and Summers' own creative talents, he was able to help transform Mies' visions into built structures. For 16 years Gene Summers was a close colleague of Mies, heading his office and working with him on many projects including the Seagram Building in New York, Bacardi's office buildings in Cuba and Mexico, and Krupps' offices in Essen. Also working independently, Summers created projects for C.F Murphy Assoc. such as the McCormick Convention Centre and the Malcolm X College in Chicago. Later with Ridgway Ltd. he was responsible for the acclaimed restoration of the Biltmore Hotels in Los Angeles and the Canada Business Center (Orange County, Canada). Familiar with bronze as a building material, Summers used this knowledge to design elegant furniture and household objects before devoting himself entirely to this area of art. This volume is the first presentation of Gene Summers' architectural and artistic work, surveying the many areas which include wood and water colours where he was active. Phyllis Lambert, founder and architect of the Canadian Centre for Architecture, and President of the International Confederation of Architectural Museums, provides an enlightening introduction to his work.

A trailblazing biologist grapples with her role in the biggest scientific discovery of our era: a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril. Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers, and will help address the world’s hunger crisis. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences—to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans.   Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery, and passionately argues that enormous responsibility comes with the ability to rewrite the code of life. With CRISPR, she shows, we have effectively taken control of evolution. What will we do with this unfathomable power?  

The teachings of Mies van der Rohe and his respect for the effects of space and material has had a great influence on the American architect and artist Gene Summers. Thanks to the technology of the day and Summers' own creative talents, he was able to help transform Mies' visions into built structures. For 16 years Gene Summers was a close colleague of Mies, heading his office and working with him on many projects including the Seagram Building in New York, Bacardi's office buildings in Cuba and Mexico, and Krupps' offices in Essen. Also working independently, Summers created projects for C.F Murphy Assoc. such as the McCormick Convention Centre and the Malcolm X College in Chicago. Later with Ridgway Ltd. he was responsible for the acclaimed restoration of the Biltmore Hotels in Los Angeles and the Canada Business Center (Orange County, Canada). Familiar with bronze as a building material, Summers used this knowledge to design elegant furniture and household objects before devoting himself entirely to this area of art. This volume is the first presentation of Gene Summers' architectural and artistic work, surveying the many areas which include wood and water colours where he was active. Phyllis Lambert, founder and architect of the Canadian Centre for Architecture, and President of the International Confederation of Architectural Museums, provides an enlightening introduction to his work.

Second Generation Cell and Gene-Based Therapies: Biological Advances, Clinical Outcomes, and Strategies for Capitalization serves as the only book on the market to bridge basic science, clinical therapy, technology development and business in the field of cellular therapy/cytotherapy. After more than two decades of painstaking fundamental research, the concept of therapeutic cells (stem cells, genes, etc.), beyond the concept of vaccines is reaching clinical trial, with mounting confidence in the safety and efficacy of these products. Nonetheless, numerous incremental technical advances remain to be achieved. Thus, this volume highlights the possible R&D paths that will ultimately facilitate clinical delivery of cutting-edge, curative products. Chapters cover hematopoietic stem cells, mesenchymal stem cells, tissue engineering, CAR-T cells, and cells of the immune system, as well as enabling technologies, such as gene and genome editing. Additionally, deep dives in product fundamentals, the history of the science, the pathobiology of diseases, the scientific and technological bases, and financing and technology adoption constraints are taken in order to unravel what will shape the cytotherapy industry in 2025 and beyond. Helps readers learn about the most current trends in cell-based therapy, their overall effectiveness from a clinical prospective, and how the industry is moving therapies forward for capitalizationPerspectives section at the end of each chapter summarizes key learnings, hypotheses, and objectives highlighted Edited and authored by scientists representing both basic and clinical research and industry, presenting a complete story of the current state and future promise of cellular therapies

STEM CELL BIOLOGY AND GENE THERAPY Edited by Peter J. Quesenberry, Gary S. Stein, Bernard Forget, and Sherman Weissman Advances in molecular genetics and recombinant DNA technology have ushered in a new era in medical therapeutic research. New insights into the molecular basis of human disease and the role played by biological regulatory mechanisms have precipitated tremendous drug development efforts backed by intensive research into human gene therapy worldwide. Stem Cell Biology and Gene Therapy is the first book to thoroughly cover major advances in the field and their applications to novel molecular therapies. This self-contained volume integrates biological and clinical components of stem cell biology, examines some of the most difficult aspects of gene therapy, and provides a systematic review of advanced gene modification techniques. Twenty essays by leading researchers address some of the most compelling topics in contemporary medical research, including: * Fundamental regulatory mechanisms that operate in stem cells * Stem cells from a therapeutic perspective, including preparations of stem cells and their therapeutic potential as vehicles for gene therapy * Delivery systems for therapeutic genes, including an overview of the most promising vectors * Clinical applications for gene therapy, covering a broad range of diseases such as hemophilia, cancers, neurological disease, and more Complete with illustrations and real-world examples of a variety of disorders, Stem Cell Biology and Gene Therapy is essential for researchers in gene therapy and members of the biotechnology industry who are developing human molecular therapies for commercial use. It is also an important reference for molecular biologists, cell biologists, immunologists, molecular geneticists, hematologists, cancer researchers, biochemists, and anyone working in internal medicine.

The study of nonlinear dynamical systems has advanced tremendously in the last 20 years, making a big impact on science and technology. This book provides all the techniques and methods used in nonlinear dynamics. The concepts and underlying mathematics are discussed in detail. The numerical and symbolic methods are implemented in C++, SymbolicC++ and Java. Object-oriented techniques are also applied. The book contains more than 150 ready-to-run programs. The text has also been designed for a one-year course at both the junior and senior levels in nonlinear dynamics. The topics discussed in the book are part of e-learning and distance learning courses conducted by the International School for Scientific Computing, University of Johannesburg. Contents: Nonlinear and Chaotic Maps; Time Series Analysis; Autonomous Systems in the Plane; Nonlinear Hamilton Systems; Nonlinear Dissipative Systems; Nonlinear Driven Systems; Controlling of Chaos; Synchronization of Chaos; Fractals; Cellular Automata; Solving Differential Equations; Neural Networks; Genetic Algorithms; Gene Expression Programming; Optimization; Discrete Wavelets; Discrete Hidden Markov Processes; Fuzzy Sets and Fuzzy Logic.

It is one of the best-known pieces of scientific trivia--that human DNA and chimpanzee DNA differ by a mere 1.6%. But are we then just chimps with a few genetic tweaks? Are our language and our technology just an extension of the grunts and ant-collecting sticks of chimps? In Not a Chimp, Jeremy Taylor describes one of the great scientific quests of our times--the effort to discover precisely what makes humans different from other primates, especially our closest evolutionary relative, the chimpanzee. Drawing on state-of-the-art science, Taylor convincingly debunks the assertion that our two species are nearly identical genetically. He sketches the picture now emerging from cutting-edge research in genetics, animal behavior, and other fields to show that the so-called 1.6% difference is effectively much larger, leading to a profound divergence between the two species. Indeed, he explains that the evolution of the human genome has accelerated since the split of chimps and humans from a common ancestor more than six million years ago. In fact, at least 7% of human genes--almost one gene in ten--have accumulated changes within the last 50,000 years. Some of the genes that have changed orchestrate entire sets of other genes, and recent studies show that it is this complex interaction--rather than the action of individual genes--that underlies speech processes, brain development, and a host of other mechanisms that make humans unique.We humans are far different, genetically speaking, than chimps. More than that, we have been the architects of our own evolution through the same processes that have produced our farm animals and crop plants. We are the apes that domesticated themselves."Should be mandatory reading for journalists who often reinforce the general public's misconception that chimps are practically human." --New Scientist

How will we handle baby-making and pregnancy in the next 5, 25 and 75 years? New reproductive technology, genetic screening and DNA-mapping have changed the 20th-century rules. In this revolutionary manifesto, Martine Rothblatt proposes a code of ethics to guide childbirth decisions in the brave new world of biotechnology.

Progress in genetic and reproductive technology now offers us the possibility of choosing what kinds of children we do and don't have. Should we welcome this power, or should we fear its implications? There is no ethical question more urgent than this: we may be at a turning-point in the history of humanity. The renowned moral philosopher and best-selling author Jonathan Glover shows us how we might try to answer this question, and other provoking and disturbing questions to which it leads. Surely parents owe it to their children to give them the best life they can? Increasingly we are able to reduce the number of babies born with disabilities and disorders. But there is a powerful new challenge to conventional thinking about the desirability of doing so: this comes from the voices of those who have these conditions. They call into question the very definition of disability. How do we justify trying to avoid bringing people like them into being? In 2002 a deaf couple used sperm donated by a friend with hereditary deafness to have a deaf baby: they took the view that deafness is not a disability, but a difference. Starting with the issues raised by this case, Jonathan Glover examines the emotive idea of "eugenics", and the ethics of attempting to enhance people, for non-medical reasons, by means of genetic choices. Should parents be free, not only to have children free from disabilities, but to choose, for instance, the colour of their eyes or hair? This is no longer a distant prospect, but an existing power which we cannot wish away. What impact will such interventions have, both on the individuals concerned and on society as a whole? Should we try to make general improvements to the genetic make-up of human beings? Is there a central core of human nature with which we must not interfere? This beautifully clear book is written for anyone who cares about the rights and wrongs of parents' choices for their children, anyone who is conce

STEM CELL BIOLOGY AND GENE THERAPY Edited by Peter J. Quesenberry, Gary S. Stein, Bernard Forget, and Sherman Weissman Advances in molecular genetics and recombinant DNA technology have ushered in a new era in medical therapeutic research. New insights into the molecular basis of human disease and the role played by biological regulatory mechanisms have precipitated tremendous drug development efforts backed by intensive research into human gene therapy worldwide. Stem Cell Biology and Gene Therapy is the first book to thoroughly cover major advances in the field and their applications to novel molecular therapies. This self-contained volume integrates biological and clinical components of stem cell biology, examines some of the most difficult aspects of gene therapy, and provides a systematic review of advanced gene modification techniques. Twenty essays by leading researchers address some of the most compelling topics in contemporary medical research, including: * Fundamental regulatory mechanisms that operate in stem cells * Stem cells from a therapeutic perspective, including preparations of stem cells and their therapeutic potential as vehicles for gene therapy * Delivery systems for therapeutic genes, including an overview of the most promising vectors * Clinical applications for gene therapy, covering a broad range of diseases such as hemophilia, cancers, neurological disease, and more Complete with illustrations and real-world examples of a variety of disorders, Stem Cell Biology and Gene Therapy is essential for researchers in gene therapy and members of the biotechnology industry who are developing human molecular therapies for commercial use. It is also an important reference for molecular biologists, cell biologists, immunologists, molecular geneticists, hematologists, cancer researchers, biochemists, and anyone working in internal medicine.

This reference is completely revised and expanded to reflect the most critical studies, controversies, and technologies impacting the medical field, including probing research on lentivirus, gutless adenovirus, bacterial and baculovirus vectors, retargeted viral vectors, in vivo electroporation, in vitro and in vivo gene detection systems, and all inducible gene expression systems. Scrutinizing every tool, technology, and issue impacting the future of gene and cell research, it is specifically written and organized for laymen, scholars, and specialists from varying backgrounds and disciplines to understand the current status of gene and cell therapy and anticipate future developments in the field.

How will we handle baby-making and pregnancy in the next 5, 25 and 75 years? New reproductive technology, genetic screening and DNA-mapping have changed the 20th-century rules. In this revolutionary manifesto, Martine Rothblatt proposes a code of ethics to guide childbirth decisions in the brave new world of biotechnology.