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Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development. In the most comprehensive resource on the topic, this third edition of Water-Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe the detailed discussion on solubility theories, solubility prediction models, the aspects of preformulation, biopharmaceutics, pharmacokinetics, regulatory, and discovery support of water-insoluble drugs to various techniques used in developing delivery systems for water-insoluble drugs. This book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies and featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field. The aim of this book is to provide a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students and pharmaceutical and biopharmaceutical graduate students to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement.

Properties and Formulation: From Theory to Real-World Application Scientists have attributed more than 40 percent of the failures in new drug development to poor biopharmaceutical properties, particularly water insolubility. Issues surrounding water insolubility can postpone or completely derail important new drug development. Even the much-needed reformulation of currently marketed products can be significantly affected by these challenges. More recently it was reported that the percentage increased to 90% for the candidates of new chemical entities in the discovery stage and 75% for compounds under development. In the most comprehensive resource on the topic, this third edition of Water-Insoluble Drug Formulation brings together a distinguished team of experts to provide the scientific background and step-by-step guidance needed to deal with solubility issues in drug development. Twenty-three chapters systematically describe the detailed discussion on solubility theories, solubility prediction models, the aspects of preformulation, biopharmaceutics, pharmacokinetics, regulatory, and discovery support of water-insoluble drugs to various techniques used in developing delivery systems for water-insoluble drugs. This book includes more than 15 water-insoluble drug delivery systems or technologies, illustrated with case studies and featuring oral and parenteral applications. Highlighting the most current information and data available, this seminal volume reflects the significant progress that has been made in nearly all aspects of this field. The aim of this book is to provide a handy reference for pharmaceutical scientists in the handling of formulation issues related to water-insoluble drugs. In addition, this book may be useful to pharmacy and chemistry undergraduate students and pharmaceutical and biopharmaceutical graduate students to enhance their knowledge in the techniques of drug solubilization and dissolution enhancement.

2 Peter of Aillyl wrote his Concepts and Insolubles, according to the best 3 estimate, in 1372. He was at that time only about twenty-two years old. He was born around 1350" in Compiegne in the De de France, although his 5 family name associates him with the village of Ailly in Picardy. In 1364 he entered the University of Paris as a 'bursar' (i. e. , the recipient of a scholarship) at the College de Navarre. He received the degree of Bachelor of Arts in 1367 and taught there until 1368, when he entered the Faculty of Theology. He became a Doctor of Theology in 1381. In the years that followed, Peter was very active in the 'conciliar' movement and in negotiations to bring about the end of the Great Schism of the West. He was elevated to the rank of Cardinal in 1411 by Pope John XXIII, the successor of Alexander V in the 'Pisa' line of Popes. He took an active part in the Council of Constance (1414-1418), which ended the Great Schism and elected Pope Martin V. Peter died on August 9, 1420. Most of the secondary literature on Peter of Ailly concerns his role in church politics, his writings on the Schism and on ecclesiastical reform, and various aspects of his theology. But Peter was active in a number of other areas as well. He wrote several works, for instance, on geography and astron­ 6 omy, including an Imago mundi read by Christopher Columbus.

2 Peter of Aillyl wrote his Concepts and Insolubles, according to the best 3 estimate, in 1372. He was at that time only about twenty-two years old. He was born around 1350" in Compiegne in the De de France, although his 5 family name associates him with the village of Ailly in Picardy. In 1364 he entered the University of Paris as a 'bursar' (i. e. , the recipient of a scholarship) at the College de Navarre. He received the degree of Bachelor of Arts in 1367 and taught there until 1368, when he entered the Faculty of Theology. He became a Doctor of Theology in 1381. In the years that followed, Peter was very active in the 'conciliar' movement and in negotiations to bring about the end of the Great Schism of the West. He was elevated to the rank of Cardinal in 1411 by Pope John XXIII, the successor of Alexander V in the 'Pisa' line of Popes. He took an active part in the Council of Constance (1414-1418), which ended the Great Schism and elected Pope Martin V. Peter died on August 9, 1420. Most of the secondary literature on Peter of Ailly concerns his role in church politics, his writings on the Schism and on ecclesiastical reform, and various aspects of his theology. But Peter was active in a number of other areas as well. He wrote several works, for instance, on geography and astron­ 6 omy, including an Imago mundi read by Christopher Columbus.

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These cable ties are manufactured from the toughest of materials, pure virgin nylon 6/6. Harsh environment grade nylon is insoluble in common solvents, alkalis, dilute mineral acids, most organic acids and most petrochemicals. patented Double Lock design, with locking teeth on both sides of the tie and at the head ensuring a stronger connection and 50% greater tensile strength than the industry standard. The bent tip ensures easy insertion into the tie head while close serrations on both sides of the tie promote precise adjustment. The smooth radiuses edges ensure easy "slip" as you tighten while finger grips on the end ensure a secure and comfortable grip when hand-tightening. Operating temperature range is 100% capacity up to 65°C (149°F), 50% capacity from 65°C to 185°C (149-365°F). Color: Black.

Potassium Chloride, Salt Alternative, for Water Softeners is a low-sodium alternative to traditional water softener salts. Made with up to 99.1% pure potassium chloride, these crystals contain low insoluble content to keep your water softener running smoothly. Diamond Crystal Water Softener Potassium Chloride is recommended for all kinds of water softeners. Potassium Chloride works in water softeners the same way that traditional water softener salt does by replacing hard water minerals. The primary difference is that hard water minerals are replaced with potassium instead of sodium.

In The Dilemma of Context, Scharfstein contends that the problems encountered with context are insoluble. He explains why this problem lays an intellectual burden on us that, while remaining inescapable,can become so heavy it destroys the understandingit was created to further.

Today the name Socrates invokes a powerful idealization of wisdom and nobility that would surprise many of his contemporaries, who excoriated the philosopher for corrupting youth. The problem of who Socrates "really" was—the true history of his activities and beliefs—has long been thought insoluble, and most recent Socratic studies have instead focused on reconstructing his legacy and tracing his ideas through other philosophical traditions. But this scholarship has neglected to examine closely a period of philosophy that has much to reveal about what Socrates stood for and how he taught: the Neoplatonic tradition of the first six centuries C.E., which at times decried or denied his importance yet relied on his methods.In The Neoplatonic Socrates, leading scholars in classics and philosophy address this gap by examining Neoplatonic attitudes toward the Socratic method, Socratic love, Socrates's divine mission and moral example, and the much-debated issue of moral rectitude. Collectively, they demonstrate the importance of Socrates for the majority of Neoplatonists, a point that has often been questioned owing to the comparative neglect of surviving commentaries on the Alcibiades, Gorgias, Phaedo, and Phaedrus, in favor of dialogues dealing explicitly with metaphysical issues. Supplemented with a contextualizing introduction and a substantial appendix detailing where evidence for Socrates can be found in the extant literature, The Neoplatonic Socrates makes a clear case for the significant place Socrates held in the education and philosophy of late antiquity.Contributors: Crystal Addey, James M. Ambury, John F. Finamore, Michael Griffin, Marilynn Lawrence, Danielle A. Layne, Christina-Panagiota Manolea, François Renaud, Geert Roskam, Harold Tarrant.

An explosive rethinking of the power and purpose of nuclear weapons—and a call for radical action Nuclear weapons have always been a serious but seemingly insoluble problem: while they’re obviously dangerous, they are also, apparently, necessary. This groundbreaking study shows why five central arguments promoting nuclear weapons are, in essence, myths. It is a myth: · that nuclear weapons necessarily shock and awe opponents, including Japan at the end of World War II · that nuclear deterrence is reliable in a crisis · that destruction wins wars · that the bomb has kept the peace for sixty-five years · and that we can’t put the nuclear genie back in the bottle Drawing on new information and the latest historical research, Wilson poses a fundamental challenge to the myths on which nuclear weapons policy is currently built. Using pragmatic arguments and an unemotional, clear-eyed insistence on the truth, he arrives at a surprising conclusion: nuclear weapons are enormously dangerous, but don’t appear to be terribly useful. In that case, he asks, why would we want to keep them? This book will be widely read and discussed by everyone who cares about war, peace, foreign policy, and security in the twenty-first century.

The industrial process of germination-which converts hard, insoluble cereals into friable, extractable grains for subsequent use as a food source for humans or yeast - is called malting. The Craft Maltsters' Handbook provides an in-depth understanding of the technical and scientific meanings of words and phrases used in malting and is an up-to-date reference on the many types of malts used in brewing and distilling today. The rise in craft micro-malting is a nod to the 19th century men and women who provided the malt for brewing/distilling and part of the growing trend of taking back an art from large multinational corporations who have come to dominate much of agriculture and manufacturing.

Today the name Socrates invokes a powerful idealization of wisdom and nobility that would surprise many of his contemporaries, who excoriated the philosopher for corrupting youth. The problem of who Socrates "really" was—the true history of his activities and beliefs—has long been thought insoluble, and most recent Socratic studies have instead focused on reconstructing his legacy and tracing his ideas through other philosophical traditions. But this scholarship has neglected to examine closely a period of philosophy that has much to reveal about what Socrates stood for and how he taught: the Neoplatonic tradition of the first six centuries C.E., which at times decried or denied his importance yet relied on his methods.In The Neoplatonic Socrates, leading scholars in classics and philosophy address this gap by examining Neoplatonic attitudes toward the Socratic method, Socratic love, Socrates's divine mission and moral example, and the much-debated issue of moral rectitude. Collectively, they demonstrate the importance of Socrates for the majority of Neoplatonists, a point that has often been questioned owing to the comparative neglect of surviving commentaries on the Alcibiades, Gorgias, Phaedo, and Phaedrus, in favor of dialogues dealing explicitly with metaphysical issues. Supplemented with a contextualizing introduction and a substantial appendix detailing where evidence for Socrates can be found in the extant literature, The Neoplatonic Socrates makes a clear case for the significant place Socrates held in the education and philosophy of late antiquity.Contributors: Crystal Addey, James M. Ambury, John F. Finamore, Michael Griffin, Marilynn Lawrence, Danielle A. Layne, Christina-Panagiota Manolea, François Renaud, Geert Roskam, Harold Tarrant.

In The Dilemma of Context, Scharfstein contends that the problems encountered with context are insoluble. He explains why this problem lays an intellectual burden on us that, while remaining inescapable,can become so heavy it destroys the understandingit was created to further.

For the average clinician, individuals with borderline personality disorder (BPD) often represent the most challenging, seemingly insoluble cases. This volume is the authoritative presentation of dialectical behavior therapy (DBT), Marsha M. Linehan's comprehensive, integrated approach to treating individuals with BPD. DBT was the first psychotherapy shown in controlled trials to be effective with BPD. It has since been adapted and tested for a wide range of other difficult-to-treat disorders involving emotion dysregulation. While focusing on BPD, this book is essential reading for clinicians delivering DBT to any clients with complex, multiple problems. Companion volumes: The latest developments in DBT skills training, together with essential materials for teaching the full range of mindfulness, interpersonal effectiveness, emotion regulation, and distress tolerance skills, are presented in Linehan's DBT Skills Training Manual, Second Edition, and DBT Skills Training Handouts and Worksheets, Second Edition. Also available: Linehan's instructive skills training videos for clients--Crisis Survival Skills: Part One, Crisis Survival Skills: Part Two, From Suffering to Freedom, This One Moment, and Opposite Action.

Intention is one of the masterworks of twentieth-century philosophy in English. First published in 1957, it has acquired the status of a modern philosophical classic. The book attempts to show in detail that the natural and widely accepted picture of what we mean by an intention gives rise to insoluble problems and must be abandoned. This is a welcome reprint of a book that continues to grow in importance.

This powerful book places the complex and apparently insoluble problems of South Africa in a new light, and movingly exhibits the great love she and the people she met share for the country. Dervla Murphy has been recording her travel experiences―treks through (among other places) India, Transylvania, and several countries in Africa―for well over thirty years. In South from the Limpopo, she continues her writings on the African continent, bringing her unique insights to the still-troubled country of South Africa.

Conceived as the answer to all of mankind's seemingly insoluble health and social problems, and promoted as a substitute for orthodox religious beliefs, the pseudoscience of eugenics recruited disciples in many countries during the latter years of the nineteenth and early years of the twentieth centuries. Nowhere was this doctrine more enthusiastically endorsed than in Germany, where the application of eugenic theory received its most fervent support. A program born of what were often contradictory opinions began, under Nazi rule, with the compulsory sterilization of thousands of Germany's citizens before morphing into the mass murder of the most vulnerable of the state's own population under the guise of so-called "euthanasia,, before ultimately escalating into a continent-wide policy of extermination of those who did not fit the Nazi eugenic template.The progress of this inexorable descent into barbarity was marked by successive stages of development. From the practical application of euthanasia through the organization dedicated to it―later on called Aktion T4―and the killing centers that this institution spawned, to the centrality of Aktion T4 to Aktion Reinhardt and the Holocaust, important elements of the historical record can be seen to emerge. How did it happen? What impact has it had on contemporary society? And what of the character and fate of the individuals involved in the gestation and implementation of this murderously inhumane quasi-religion? These deceptively simple questions require complex and often disturbing answers, as shown by Melvyn Conroy in this important work.

Intention is one of the masterworks of twentieth-century philosophy in English. First published in 1957, it has acquired the status of a modern philosophical classic. The book attempts to show in detail that the natural and widely accepted picture of what we mean by an intention gives rise to insoluble problems and must be abandoned. This is a welcome reprint of a book that continues to grow in importance.

This book does nothing less than provide an account of the intellectual lineage of abstract algebra. The development of abstract algebra was propelled by the need for new tools to address certain classical problems that appeared insoluble by classical means. A major theme of the book is to show how abstract algebra has arisen in attempting to solve some of these classical problems, providing a context from which the reader may gain a deeper appreciation of the mathematics involved. Mathematics instructors, algebraists, and historians of science will find the work a valuable reference.

This book was originally published in 1970. Aspect - the relationship between imperfective and perfective verbs - has always been one of the features of Russian grammar that English-speaking students find particularly difficult. It has in fact often appeared to be an insoluble mystery, largely because of the frequency of exceptions to the stated rules. Mr Forsyth suggests that this is the fault of the rules, and that the difficulties in the way of understanding the functioning of aspect stem chiefly from the faulty basis of the traditional definitions. The operation of imperfective and perfective are examined in all forms of the verb including the imperative, infinitive, participles and gerunds, and their usage is amply illustrated by examples from Russian. The aim is to present a total picture of aspect in the Russian language which will be of practical interest to advanced students of Russian, and also contributed to the theoretical study of aspect as a grammatical category.