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In recent years, in association with progress and innovation in the field of pharmaceutical technology, there has been an increasing effort to develop prolonged release dosage forms for many drugs. Correspondingly, a growing number of new prolonged release dosage forms have been submitted for regulatory approval. Prolonged release dosage forms have many advantages in safety and efficacy over immediate release drug products in that the frequency of dosing can be reduced, drug efficacy can be prolonged and the incidence and/or intensity of adverse effects can be decreased. However, some prolonged release dosage forms have less clear rationale or are developed for active ingredients which are not appropriate for prolonged release dosage forms. In other cases, prolonged release dosage forms are designed without full consideration of the basic properties of the drugs. Moreover, standards for dissolution tests, which are important for evaluating prolonged release dosage forms, have not appropriately been established. As a result, it is often difficult to evaluate whether a prolonged release dosage form is acceptable or not.

Dr. Rafael Gonzalez Maldonado is a neurologist and author of popular books on Parkinson's disease, “The Strange Case of Dr. Parkinson”, “Unorthodox treatments in Parkinson's disease” “Parkinson and stress”, “Conjectures of a neurologist...” “Mucuna pruriens” is a bean that grows in the tropics. It is very rich in natural levodopa that is better tolerated and more potent than the synthetic levodopa in Sinemet or Stalevo. Two prestigious neurologists have patented extracts of mucuna seeds as a treatment for Parkinson's. Meanwhile, patients have recorded their positive experiences with mucuna; they buy it online (no prescription needed) and use it in secrecy without consulting their neurologist. Neither the patients nor the doctors (most of them) have clear ideas about this plant, its ingredients (not only levodopa), the proportions in which it is absorbed, or how to manage it. "Mucuna versus Parkinson: Natural Levodopa Treatment" is so far the most complete and up-to-date monograph on the subject, it describes the theoretical and practical approaches to the use of this plant as a treatment option for Parkinson's disease. Also included are more than one hundred of references.

Dr. Rafael Gonzalez Maldonado is a neurologist and author of popular books on Parkinson's disease, “The Strange Case of Dr. Parkinson”, “Unorthodox treatments in Parkinson's disease” “Parkinson and stress”, “Conjectures of a neurologist...” “Mucuna pruriens” is a bean that grows in the tropics. It is very rich in natural levodopa that is better tolerated and more potent than the synthetic levodopa in Sinemet or Stalevo. Two prestigious neurologists have patented extracts of mucuna seeds as a treatment for Parkinson's. Meanwhile, patients have recorded their positive experiences with mucuna; they buy it online (no prescription needed) and use it in secrecy without consulting their neurologist. Neither the patients nor the doctors (most of them) have clear ideas about this plant, its ingredients (not only levodopa), the proportions in which it is absorbed, or how to manage it. "Mucuna versus Parkinson: Natural Levodopa Treatment" is so far the most complete and up-to-date monograph on the subject, it describes the theoretical and practical approaches to the use of this plant as a treatment option for Parkinson's disease. Also included are more than one hundred of references.

La levodopa natural de la mucuna tiene ventajas sobre el Sinemet. El ginkgo despabila a los parkinsonianos que se duermen de día por las pastillas. La pasiflora tranquiliza sin los problemas de las benzodiacepinas. La bacopa mejora la memoria. El ginseng evita los bajones de tensión. El té aumenta el efecto de los medicamentos. La plantago mejora la movilidad del intestino. Hay dietas, masajes y música que ayudan mucho. El ejercicio al aire libre es la mejor prevención... Hay muchos remedios naturales para la enfermedad de Parkinson. Aquí aparecen expuestos con claridad y fundamentados (más de 600 citas bibliográficas), en este último libro del Dr. Rafael González Maldonado, neurólogo y conocido divulgador científico: "El extraño caso del Dr. Parkinson", "Tratamientos heterodoxos en la enfermedad de Parkinson", "Conjeturas de un neurólogo que escuchó a mil parkinsonianos", "Parkinson y estrés"...

La levodopa natural de la mucuna tiene ventajas sobre el Sinemet. El ginkgo despabila a los parkinsonianos que se duermen de día por las pastillas. La pasiflora tranquiliza sin los problemas de las benzodiacepinas. La bacopa mejora la memoria. El ginseng evita los bajones de tensión. El té aumenta el efecto de los medicamentos. La plantago mejora la movilidad del intestino. Hay dietas, masajes y música que ayudan mucho. El ejercicio al aire libre es la mejor prevención... Hay muchos remedios naturales para la enfermedad de Parkinson. Aquí aparecen expuestos con claridad y fundamentados (más de 600 citas bibliográficas), en este último libro del Dr. Rafael González Maldonado, neurólogo y conocido divulgador científico: "El extraño caso del Dr. Parkinson", "Tratamientos heterodoxos en la enfermedad de Parkinson", "Conjeturas de un neurólogo que escuchó a mil parkinsonianos", "Parkinson y estrés"...