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The group of chemicals known collectively as neurotransmitters form the basis of a complex communication system between nerve cells. It is a system that is constantly subtly refined and regulated via the modulating action of other neurotransmitters, circulating hormones, the products of local tissues and the action of various drugs (from both medicinal and socially abused sources). In this book, acknowledged authorities concisely describe the basic mechanisms involved in neurotransmitter release modulation in the different parts of the nervous system. This includes a quantitative evaluation of the significance of modulation, a summary of its biological ramifications and potential clinical relevance.

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Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. This volume in the Epigenetics and Human Health series explores the intersection of diet and epigenetic modifications. It provides the reader with the latest research on how diet can influence our genetic and epigenetic profiles, thereby affecti.

This volume of the Handbook of Neurochemistry and Molecular Biology focuses on molecular events involved in synapse formation, synaptic plasticity and ongoing neural activity. The volume explores axonal growth cones, synapse development, and mechanisms of LTP and LTD, and calcium dynamics. Particular attention is given to function and trafficking of membrane proteins including various ion channels, aquaporines, gap junctions.

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Iron is indispensable for the growth, development and well-being of almost all living organisms. Biological systems from bacteria, fungi and plants to humans have evolved systems for the uptake, utilisation, storage and homeostasis of iron. Its importance for microbial growth makes its uptake systems  a natural target for  pathogenic microorganisms and parasites. Uniquely, humans  suffer from both iron deficiency and iron overload, while the capacity of iron to generate highly reactive free radicals, causing oxidative stress, is  associated with a wide range of human pathologies, including many neurodegenerative diseases. Whereas some essential metal ions like copper and zinc are closely linked with iron metabolism, toxic metals like aluminium and cadmium can interfere with iron metabolism. Finally, iron metabolism and homeostasis are key targets for the development of new drugs for human health.The 4th edition of Iron Metabolism  is written in a lively style by one of the leaders in the field, presented in colour  and covers the latest discoveries in this exciting area. It will be essential reading for researchers and students in biochemistry, molecular biology, microbiology, cell biology, nutrition and medical sciences. Other interested groups include biological inorganic chemists with an interest in iron metabolism, health professionals with an interest in diseases of iron metabolism, or of diseases in which iron uptake systems are involved (eg. microbial and fungal infections, cancer, neurodegenerative disorders), and researchers in the pharmaceutical industry interested in developing novel drugs targeting iron metabolism/homeostasis.

Like New condition. Great condition, but not exactly fully crisp. The book may have been opened and read, but there are no defects to the book, jacket or pages. 1.59

This book pursues possible strategies for synthesising mainly organic compounds, particularly those of interest to the health sector and related industries. Topics covered include addition reactions of aldehydes and ketones; the use of organometallic reagents to form carbon-carbon bonds (eg Grignard reagents); and radical reactions, including selectivity and chain reactions. Retrosynthetic analysis is introduced as a strategy for developing syntheses, along with biochemical pathways. Mechanism and Synthesis concludes with a Case Study on polymers, which demonstrates how chain reactions can be used to build up useful materials with specific properties, such as contact lenses. The Molecular World series provides an integrated introduction to all branches of chemistry for both students wishing to specialise and those wishing to gain a broad understanding of chemistry and its relevance to the everyday world and to other areas of science. The books, with their Case Studies and accompanying multi-media interactive CD-ROMs, will also provide valuable resource material for teachers and lecturers. (The CD-ROMs are designed for use on a PC running Windows 95, 98, ME or 2000.)

Book is in Used-VeryGood condition. Pages and cover are clean and intact. Used items may not include supplementary materials such as CDs or access codes. May show signs of minor shelf wear and contain very limited notes and highlighting. 1.74

These volumes present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer and neurodegenerative diseases. These comprehensive volumes integrate the most innovative and current findings from several related disciplines of scientific research, including pathology, genetics, virology, cell biology, immunology, and molecular biology.

Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students. Drawing on the latest research in this dynamic field, author Lauren Pecorino makes cutting-edge science readily accessible. Using the hallmarks of cancer as a starting point, the text looks at the cellular and molecular mechanisms underpinning the transformation of cells into cancer cells. After discussing the theory, each chapter then demonstrates how this knowledge can be directly applied to the development of new targeted therapies, giving students a clear appreciation of how the theory translates to tackling the disease. Molecular Biology of Cancer, Fourth Edition, features a variety of pedagogical features--"Pause and think," "How do we know that?," self-tests, and activities--to help students engage with, and master, the concepts presented. It provides students with a solid understanding of the essentials and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit.A Companion Website contains resources for instructors--downloadable figures from the book and a test bank of multiple-choice questions--and related web links for students.

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The main argument of this book is that cell signalling via nerves, hormones, local mediators and growth factors are not distinct phenomena, but branches of one general mechanism and should therefore be studied in an integrated manner. This volume is designed to act as a bridge between general texts and is aimed at biologists coming to the topic from a variety of backgrounds. The first two chapters introduce the general concepts of intracellular signalling and also cover the topic of direct cell-to-cell communication by cytoplasmic bridges (gap junctions). The remaining chapters cover the first and second messengers, starting with their structure, synthesis and release, progressing to the target cell and then working from the membrane inwards towards the nucleus. There is also a section on the mechanism of nervous conduction and the regulation of the ionic balace of cells. The final chapters discuss the regulation of cell growth and division and the special case of messengers acting via nuclear receptors.

Neuroscientists investigate the mechanisms of spatial memory. Molecular biologists study the mechanisms of protein synthesis and the myriad mechanisms of gene regulation. Ecologists study nutrient cycling mechanisms and their devastating imbalances in estuaries such as the Chesapeake Bay. In fact, much of biology and its history involves biologists constructing, evaluating, and revising their understanding of mechanisms. With In Search of Mechanisms, Carl F. Craver and Lindley Darden offer both a descriptive and an instructional account of how biologists discover mechanisms. Drawing on examples from across the life sciences and through the centuries, Craver and Darden compile an impressive toolbox of strategies that biologists have used and will use again to reveal the mechanisms that produce, underlie, or maintain the phenomena characteristic of living things. They discuss the questions that figure in the search for mechanisms, characterizing the experimental, observational, and conceptual considerations used to answer them, all the while providing examples from the history of biology to highlight the kinds of evidence and reasoning strategies employed to assess mechanisms. At a deeper level, Craver and Darden pose a systematic view of what biology is, of how biology makes progress, of how biological discoveries are and might be made, and of why knowledge of biological mechanisms is important for the future of the human species.

Inflammation is important in many diseases, yet it is hard to find current information on the pertinent cellular and molecular mechanisms of inflammation. This book is a current and authoritative review of various aspects of inflammation in mammalian organisms. Basic principles, including regulation by cytokines, lipid mediators, reactive oxygen species and leukocyte recruitment are followed by chapters on integrative aspects of inflammation, such as neutrophil extracellular traps, sepsis and granulomatous inflammation. Readership: Graduate students, medical doctors/ practitioners, researchers, pathologists and nutritionists in medicine and healthcare.

Improving tolerance to heat stress is a major challenge in many crops, especially C3 crops, given the threat of recent global warming. While significant achievements have been made on understanding the molecular and physiological mechanisms to short–term exposure to high temperature, the physiological mechanisms of summer tolerance in fields, which are characterized by prolonged exposure to high temperature stress, are not still well understood. In this study, six experiments were conducted to clarify the physiological mechanisms of tolerance to high temperature stress by comparing between genotypes, populations and different species including C3 and C4 photosynthetic types. Overall, although the complexity of heat tolerance was revealed by the involvement of various mechanisms such as suppression of ROS, scavenging of toxic ROS, and leaf functions, this study definitively showed that the oxidative stress resulting from the excessive production of ROS is the main cause of damages under heat stress.

The third edition of The Neuron provides a comprehensive first course in the cell and molecular biology of nerve cells. The first part of the book covers the properties of the many ion channels that shape the way a single neuron generates varied patterns of electrical activity, as well as the molecular mechanisms that convert electrical activity into the secretion of neurotransmitter hormones at synaptic junctions between neurons. The second part covers the biochemical pathways that are linked to the action of neurotransmitters and can alter the cellular properties of neurons or sensory cells that transduce information from the outside world into the electrical code used by neurons. The final section reviews our rapidly expanding knowledge of the molecular factors that induce an undifferentiated cell to become a neuron, and then guide it to form appropriate synaptic connections with its partners. This section also focuses on the role of ongoing experience and activity in shaping these connections, and finishes with an account of mechanisms thought to underlie the phenomena of learning and memory.

Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses.·    Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies·    Uses a didactic approach with basic biological or theoretical background for the methodology presented·    Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology·    Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts·    “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition

Many of the cells in our body undergo tightly regulated replication to enable growth to occur, and to ensure that damaged or worn out tissues are replaced. Regulation is mediated via many different mechanisms; it is when these mechanisms fail, and regulation is lost, that cancer can result. Recent advances in molecular cell biology have greatly expanded our understanding of the processes and mechanisms which underpin the regulation of cell replication, and what is happening at the molecular level when these fail. The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, and shows how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents. Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal components of the regulatory machinery through which cell division is controlled, and explains how the failure of these components can lead to the onset of cancer. Uniquely, within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies. The Molecular Biology of Cancer will prove a valuable resource for any student wishing to gain an insight into the molecular basis of the disease, and possible solutions for its effective control.Companion Web Site Features figures from the book available to download, to facilitate lecture preparation, and a web link library to give students easy access to relevant online resources.

Surface organometallic chemistry is a new field bringing together researchers from organometallic, inorganic, and surface chemistry and catalysis. Topics ranging from reaction mechanisms to catalyst preparation are considered from a molecular basis, according to which the "active site" on a catalyst surface has a supra-molecular character. This. the first book on the subject, is the outcome of a NATO Workshop held in Le Rouret. France, in May. 1986. It is our hope that the following chapters and the concluding summary of recommendations for research may help to provide a definition of surface organometallic chemistry. Besides catalysis. the central theme of the Workshop, four main topics are considered: 1) Reactions of organometallics with surfaces of metal oxides, metals. and zeolites; 2) Molecular models of surfaces, metal oxides, and metals; 3) Molecular approaches to the mechanisms of surface reactions; 4) Synthesis and modification of zeolites and related microporous solids. Most surface organometallic chemistry has been carried out on amorphous high-surf ace-area metal oxides such as silica. alumina. magnesia, and titania. The first chapter. contributed by KNOZINGER. gives a short summary of the structure and reactivity of metal oxide surfaces. Most of our understanding of these surfaces is based on acid­ base and redox chemistry; this chemistry has developed from X-ray and spectroscopic data, and much has been inferred from the structures and reactivities of adsorbed organic probe molecules. There are major opportunities for extending this understanding by use of well-defined (single crystal) oxide surfaces and organometallic probe molecules.