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Our thanks go to our colleagues at the VU Univer- Preface to the Third Edition sity Medical Center and to those in other hospitals Reading through the prefaces of the two previous edi- who referred their patients to us. We are indebted to tions,we can say that much of what was said there still all colleagues who allowed us to use their MR images, holds. At the same time,however,much has changed. published or unpublished,making it possible for us to There has been immense progress in the technical present illustrations of nearly all known white matter possibilities of magnetic resonance and in the know- disorders. Two colleagues were particularly helpful ledge of genetic defects, biochemical abnormalities, and provided us with essential and unpublished f- and cellular processes underlying myelin disorders. ures: our friends Susan Blaser,from the Hospital for This immense progress has prompted us to embark Sick Children in Toronto,and Zoltán Patay,from the upon the enormous task of rewriting the previous King Faisal Hospital in Riyadh. edition and adding 40 chapters. In doing so we have Many people at the VU University Medical Center tried to cover most white matter disorders,hereditary have been of great technical help to us in producing and acquired,and to present a collection of images to high quality images and in providing secretarial illustrate the field to the fullest possible extent. This assistance. The contributions of these people are edition will therefore be more complete than the pre- mentioned separately in the acknowledgements.

Our thanks go to our colleagues at the VU Univer- Preface to the Third Edition sity Medical Center and to those in other hospitals Reading through the prefaces of the two previous edi- who referred their patients to us. We are indebted to tions,we can say that much of what was said there still all colleagues who allowed us to use their MR images, holds. At the same time,however,much has changed. published or unpublished,making it possible for us to There has been immense progress in the technical present illustrations of nearly all known white matter possibilities of magnetic resonance and in the know- disorders. Two colleagues were particularly helpful ledge of genetic defects, biochemical abnormalities, and provided us with essential and unpublished f- and cellular processes underlying myelin disorders. ures: our friends Susan Blaser,from the Hospital for This immense progress has prompted us to embark Sick Children in Toronto,and Zoltán Patay,from the upon the enormous task of rewriting the previous King Faisal Hospital in Riyadh. edition and adding 40 chapters. In doing so we have Many people at the VU University Medical Center tried to cover most white matter disorders,hereditary have been of great technical help to us in producing and acquired,and to present a collection of images to high quality images and in providing secretarial illustrate the field to the fullest possible extent. This assistance. The contributions of these people are edition will therefore be more complete than the pre- mentioned separately in the acknowledgements.

MRI Atlas of Pediatric Brain Maturation and Anatomy and its software application offer a concise review of normal myelin, myelination, and commonly used MR techniques. Practical points on using MRI to assess the progress of brain maturation are discussed, followed by clinically relevant summaries of normal MR appearances grouped by age. The book version contains abridged sets of normal reference MR images between preterm and 3 years of age. The software proivides immediate access to over 13,000 high resolution, normal comparison MR images of subjects ranging in age from 32 gestational weeks to 3 years. Designed as both a practical clinical resource and educational tool, the software is ideal for use at the imaging workstation where one can rapidly bring up complete sets of high quality, scrollable MR reference images with guiding annotations to ensure more accurate and clinically valuable interpretations. Suspected deviations from normal brain development or MR signal can be more confidently identified or excluded, and diagnostic errors arising from unfamiliarity with the changing MR appearances of the immature brain can be minimized.

MRI Atlas of Pediatric Brain Maturation and Anatomy and its software application offer a concise review of normal myelin, myelination, and commonly used MR techniques. Practical points on using MRI to assess the progress of brain maturation are discussed, followed by clinically relevant summaries of normal MR appearances grouped by age. The book version contains abridged sets of normal reference MR images between preterm and 3 years of age. The software proivides immediate access to over 13,000 high resolution, normal comparison MR images of subjects ranging in age from 32 gestational weeks to 3 years. Designed as both a practical clinical resource and educational tool, the software is ideal for use at the imaging workstation where one can rapidly bring up complete sets of high quality, scrollable MR reference images with guiding annotations to ensure more accurate and clinically valuable interpretations. Suspected deviations from normal brain development or MR signal can be more confidently identified or excluded, and diagnostic errors arising from unfamiliarity with the changing MR appearances of the immature brain can be minimized.