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Our thanks go to our colleagues at the VU Univer- Preface to the Third Edition sity Medical Center and to those in other hospitals Reading through the prefaces of the two previous edi- who referred their patients to us. We are indebted to tions,we can say that much of what was said there still all colleagues who allowed us to use their MR images, holds. At the same time,however,much has changed. published or unpublished,making it possible for us to There has been immense progress in the technical present illustrations of nearly all known white matter possibilities of magnetic resonance and in the know- disorders. Two colleagues were particularly helpful ledge of genetic defects, biochemical abnormalities, and provided us with essential and unpublished f- and cellular processes underlying myelin disorders. ures: our friends Susan Blaser,from the Hospital for This immense progress has prompted us to embark Sick Children in Toronto,and Zoltán Patay,from the upon the enormous task of rewriting the previous King Faisal Hospital in Riyadh. edition and adding 40 chapters. In doing so we have Many people at the VU University Medical Center tried to cover most white matter disorders,hereditary have been of great technical help to us in producing and acquired,and to present a collection of images to high quality images and in providing secretarial illustrate the field to the fullest possible extent. This assistance. The contributions of these people are edition will therefore be more complete than the pre- mentioned separately in the acknowledgements.

Our thanks go to our colleagues at the VU Univer- Preface to the Third Edition sity Medical Center and to those in other hospitals Reading through the prefaces of the two previous edi- who referred their patients to us. We are indebted to tions,we can say that much of what was said there still all colleagues who allowed us to use their MR images, holds. At the same time,however,much has changed. published or unpublished,making it possible for us to There has been immense progress in the technical present illustrations of nearly all known white matter possibilities of magnetic resonance and in the know- disorders. Two colleagues were particularly helpful ledge of genetic defects, biochemical abnormalities, and provided us with essential and unpublished f- and cellular processes underlying myelin disorders. ures: our friends Susan Blaser,from the Hospital for This immense progress has prompted us to embark Sick Children in Toronto,and Zoltán Patay,from the upon the enormous task of rewriting the previous King Faisal Hospital in Riyadh. edition and adding 40 chapters. In doing so we have Many people at the VU University Medical Center tried to cover most white matter disorders,hereditary have been of great technical help to us in producing and acquired,and to present a collection of images to high quality images and in providing secretarial illustrate the field to the fullest possible extent. This assistance. The contributions of these people are edition will therefore be more complete than the pre- mentioned separately in the acknowledgements.

MRI Atlas of Pediatric Brain Maturation and Anatomy and its software application offer a concise review of normal myelin, myelination, and commonly used MR techniques. Practical points on using MRI to assess the progress of brain maturation are discussed, followed by clinically relevant summaries of normal MR appearances grouped by age. The book version contains abridged sets of normal reference MR images between preterm and 3 years of age. The software proivides immediate access to over 13,000 high resolution, normal comparison MR images of subjects ranging in age from 32 gestational weeks to 3 years. Designed as both a practical clinical resource and educational tool, the software is ideal for use at the imaging workstation where one can rapidly bring up complete sets of high quality, scrollable MR reference images with guiding annotations to ensure more accurate and clinically valuable interpretations. Suspected deviations from normal brain development or MR signal can be more confidently identified or excluded, and diagnostic errors arising from unfamiliarity with the changing MR appearances of the immature brain can be minimized.

Clinics in Developmental Medicine Well over 200 illustrations, many in colour Co-authored by two experts in neuropathology and neuroimaging Takes a quantitative approach to brain growth in weight, gyrus formation, myelination, and spectroscopy of the developing brain. The only book in this field to include chapters in angiogenesis, fetal behaviour, and reactions to chronic illness. This book is about human brain development, focusing on the last half of gestation and the neonatal and infant periods. These periods bring the greatest risk for the acquisition of childhood functional neurologic deficits, including cerebral palsy, developmental delay and intellectual disability. Section 1 covers typical development, including growth in brain weight, ventricular surfaces, gyral development, myelinated tract development, magnetic resonance spectroscopy, and angiogenesis, all serving as reference points for section 2, which deals with common acquired brain abnormalities, some of which are often underemphasized or overlooked. The topics in section 2 include retrocerebellar cysts, abnormal events in fetal brain, white-matter abnormalities, lesions of gray and white matter, hemorrhage, ventriculomegaly and hydrocephalus, late expressions of fetal brain disease, and reactions of the developing brain to chronic disease. Between sections 1 and 2 is a chapter on embryonic and fetal physiologic reactions to external stimuli. Where appropriate, the authors have combined pathologic with neuroimaging examples to help the reader better understand the neuroimages that they encounter. Much of the information in the book is based on data from the National Collaborative Perinatal Project, still the only large autopsy survey of late fetal brain lesions. Readership Developmental neurobiologists, neuroscientists, paediatricians, neuropathologists, pediatric neuroradiologists, pediatric neurologists, neonatologists, perinatologists.

MRI Atlas of Pediatric Brain Maturation and Anatomy and its software application offer a concise review of normal myelin, myelination, and commonly used MR techniques. Practical points on using MRI to assess the progress of brain maturation are discussed, followed by clinically relevant summaries of normal MR appearances grouped by age. The book version contains abridged sets of normal reference MR images between preterm and 3 years of age. The software proivides immediate access to over 13,000 high resolution, normal comparison MR images of subjects ranging in age from 32 gestational weeks to 3 years. Designed as both a practical clinical resource and educational tool, the software is ideal for use at the imaging workstation where one can rapidly bring up complete sets of high quality, scrollable MR reference images with guiding annotations to ensure more accurate and clinically valuable interpretations. Suspected deviations from normal brain development or MR signal can be more confidently identified or excluded, and diagnostic errors arising from unfamiliarity with the changing MR appearances of the immature brain can be minimized.

Clinics in Developmental Medicine Well over 200 illustrations, many in colour Co-authored by two experts in neuropathology and neuroimaging Takes a quantitative approach to brain growth in weight, gyrus formation, myelination, and spectroscopy of the developing brain. The only book in this field to include chapters in angiogenesis, fetal behaviour, and reactions to chronic illness. This book is about human brain development, focusing on the last half of gestation and the neonatal and infant periods. These periods bring the greatest risk for the acquisition of childhood functional neurologic deficits, including cerebral palsy, developmental delay and intellectual disability. Section 1 covers typical development, including growth in brain weight, ventricular surfaces, gyral development, myelinated tract development, magnetic resonance spectroscopy, and angiogenesis, all serving as reference points for section 2, which deals with common acquired brain abnormalities, some of which are often underemphasized or overlooked. The topics in section 2 include retrocerebellar cysts, abnormal events in fetal brain, white-matter abnormalities, lesions of gray and white matter, hemorrhage, ventriculomegaly and hydrocephalus, late expressions of fetal brain disease, and reactions of the developing brain to chronic disease. Between sections 1 and 2 is a chapter on embryonic and fetal physiologic reactions to external stimuli. Where appropriate, the authors have combined pathologic with neuroimaging examples to help the reader better understand the neuroimages that they encounter. Much of the information in the book is based on data from the National Collaborative Perinatal Project, still the only large autopsy survey of late fetal brain lesions. Readership Developmental neurobiologists, neuroscientists, paediatricians, neuropathologists, pediatric neuroradiologists, pediatric neurologists, neonatologists, perinatologists.