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This illustrated biography presents the compelling yet overlooked story of a pioneer in the medical sciences, Rudolf Magnus. Though Magnus was also an authority in the field of pharmacology, it was his neurophysical work on posture that made him famous throughout the world and ensured his legacy with the "Magnus & de Kleijn reflexes." His historic volume on posture, Körperstellung, led to his nomination, with de Kleijn, for the 1927 Nobel Prize. Moving from his childhood through his illustrious scientific career, this volume is essential reading for historians of science and those interested in European medical history.

This illustrated biography presents the compelling yet overlooked story of a pioneer in the medical sciences, Rudolf Magnus. Though Magnus was also an authority in the field of pharmacology, it was his neurophysical work on posture that made him famous throughout the world and ensured his legacy with the "Magnus & de Kleijn reflexes." His historic volume on posture, Körperstellung, led to his nomination, with de Kleijn, for the 1927 Nobel Prize. Moving from his childhood through his illustrious scientific career, this volume is essential reading for historians of science and those interested in European medical history.

Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields― from pharmacology to medicinal chemistry to biophysics to clinical medicine.

Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields― from pharmacology to medicinal chemistry to biophysics to clinical medicine.

This new 9th edition of The Pill Book contains more profiles of commonly prescribed drugs than any other consumer reference.  Compiled by a team of eminent pharmacologists, it is based on official, FDA-approved information usually available only to doctors and pharmacists, plus the latest information gathered from computer databases and on-line resources.  It synthesizes the most important facts about each drug in a concise, readable, easy-to-understand entry.No home should be without this book!For nearly two decades, millions of consumers have trusted The Pill Book to provide official, FDA-approved drug information plus guidelines from leading pharmacists. Each drug is profiled in a concise, readable, and easy-to-understand entry, making The Pill Book the perfect reference when you have questions about the medications your doctor prescribes.The consumer's guide to pills--more than 35 important new drugs approved for sale in 2000 and dozens of new brand names in this completely revised 9th edition.With more than 11 million copies in print, The Pill Book is the best-selling consumer drug reference ever, offering the most up-to-date, comprehensive information, in a format designed for ease of use.The most up-to-date information about the 1,500 most commonly prescribed drugs in the United States: Generic and brand-name listings that can help you save money What the drug is for, and how it works Usual dosages, and what to do if a dose is skipped Side effects and possible adverse reactions, highlighted for quick reference Interactions with other drugs and food Overdose and addiction potential Alcohol-free and sugar-free medications Information for seniors, pregnant and breast-feeding women, children, and others with special needs Cautions and warnings, and when to call your doctorPLUS32 pages of actual-size color photographs of most prescription pills

This highly anticipated text is the only publication on pharmacology and ototoxicity written specifically for audiologists. With contributions from leading audiologists, basic scientists, pharmacologists, and otolaryngologists, Pharmacology and Ototoxicity for Audiologists provides both basic and advanced coverage of topics critical to successful clinical practice. Fundamental concepts and terminology of pharmacology, biochemistry of the auditory system, and mechanisms of toxicity are covered, along with specific chapters on drug and noise-induced ototoxicity. This text is absolutely essential for anyone working in the hearing sciences and hearing healthcare.

The life of Jan Evangelista Purkinje (1787-1869) has fascinated students from many disciplines. Histologists marvel at his early descriptions of cells; physiologists admire his attempts to relate structure to function; pharmacologists view in awe his heroic experiments on self-administered drugs; forensic scientists acknowledge his role in the use of fingerprints for identification; and Czech patriots salute his awakening of pride in their nation. Yet all these achievements followed his initial enquiries into vision. It is this psychological dimension that fostered this collaboration. As the title suggests, the present volume is bifocal. In the narrow sense it refers to Purkinje's studies of vision, but in its broader view it concerns Purkinje's anticipation of neuroscience. Purkinje provided evidence to support both its cellular and its conceptual base. At the cellular level his acute vision is immortalized within our bodies. At the conceptual level, he sought to relate subjective phenomena to their objective underpinnings--to link psychology to physiology. Vision provides a bond that unites psychology and physiology, and it is this bond that was strengthened by Purkinje's enquiries. The authors have tried to provide a context in which Purkinje's descriptions of visual phenomena can be placed. In some cases this exposes clear precursors of research for which Purkinje has been credited. In others, there was nothing to suggest the phenomena that he exposed. The book translates Purkinje's initial masterpiece on subjective vision and places it in the context of emerging views of neuroscience.

Noting the need for clear and detailed information on Chinese herbal medicine, Jennes presents a volume (a reprint from 2004) for practitioners, students, pharmacologists, and researchers. He covers the potential for toxicity in general, types of interactions, and medicines that have been noted as harmful. The bulk of the book comprises 100 formulas and their medicinal components.Organized by Chinese name, the formulas are accompanied by information on potential for toxicity and interactions with other medicine, category, functions, indications, and dosage. Four indexes--by Pinyin formula, English forsmula, Pinyin herb, and Latin herb--are provided. The included CD-ROM is searchable by formula name, herb name, and class of Western drug. Jennes practices traditional Chinese medicine at a clinic in Colorado. Annotation ©2006 Book News, Inc., Portland, OR (booknews.com)

Dry whiskey, Divine herb, Devil’s root, Medicine of God, Peyote: for some people, to use it is to hear colors and see sounds. For many Native Americans, it brings an ability to reach out of their physical lives, to communicate with the spirits, and to become complete. For chemists, pharmacologists, and psychiatrists, the plant is fascinating in its complexity and in the ways its chemicals work upon the human mind. What is it in peyote that causes such unusual effects? Can modern medical science learn anything from Native Americans’ use of peyote in curing a wide variety of ailments? What is the Native American Church, and how do its members use peyote? Does anyone have the legal right to use drugs or controlled substances in religious ceremonies? Within this volume are answers to these and dozens of other questions surrounding the controversial and remarkable cactus. Greatly expanded and brought up-to-date from the 1980 edition, these pages describe peyote ceremonies and the users’ experiences, and also cover the many scientific and legal aspects of using the plant. Well written, informative, comprehensive, and enlightening, the book will be welcomed by counselors, anthropologists, historians, physicians, chemists, lawyers, and observers of the contemporary drug scene, as well as by interested general readers.

This introduction to the mechanisms by which the body metabolizes and excretes administered drugs is directed at advanced undergraduate biochemists, pharmacologists, pre-clinical medical strudents and advanced undergraduate/postgraduate toxicologists. The subject is approached from both biochemical and physiological angles. The examples of drug metabolism have been kept clinically relevant, so that the practical importance of the subject can be easily appreciated. The book contains a section of experimental procedures for setting up student practicals in drug metabolism.

With a sense of urgency, Dr. Tyler has collected and transcribed some 750 folk remedies still alive in the memories of more than 175 Hoosier-area correspondents. The pharmacologist, who has thirty years of experience with natural-product remedies, fears these cures will soon be forgotten, since modern medicine usually writes them off as hoax, and those who practice them are becoming fewer and fewer. For Tyler, however, folk medicine is worthy of scientific research; after all, scientists discovered morphine from opium poppy, digoxin from foxglove, and ergotamine from ergot fungus by observing the efficacy of these ancient folk remedies. By suggesting further investigation of some remedies, warning readers against downright dangerous cures, and noting the constitutive ingredients of those proven effective, Tyler invites further illumination of this shady region between superstition and science while entertaining his reader with much fascinating medical tore. Hoosiers, folklore followers, physicians, and pharmacologists will appreciate the meticulous clarity of Tyler's scientific commentary on folk medicines.

This highly anticipated text is the only publication on pharmacology and ototoxicity written specifically for audiologists. With contributions from leading audiologists, basic scientists, pharmacologists, and otolaryngologists, Pharmacology and Ototoxicity for Audiologists provides both basic and advanced coverage of topics critical to successful clinical practice. Fundamental concepts and terminology of pharmacology, biochemistry of the auditory system, and mechanisms of toxicity are covered, along with specific chapters on drug and noise-induced ototoxicity. This text is absolutely essential for anyone working in the hearing sciences and hearing healthcare.

This new edition has been fully revised to bring pharmacologists and trainees fully up to date with the latest developments in the field of medical pharmacology. Beginning with an introduction to general pharmacological principles, the following sections discuss drugs for common and less common disorders found in different regions of the body. The seventh edition includes new drugs, as well as the latest therapeutic guidelines from authoritative sources such as the World Health Organisation (WHO) and the British National Formulary (BNF). Each topic includes key point summary boxes as well as illustrations, flowcharts and tables to enhance learning. A problem-directed study question at the end of each chapter helps trainees test their knowledge. An extensive appendices section includes a list of essential medicines, drugs that should/shouldn t be prescribed in pregnancy and lactation, and suggestions for further reading. Key points Fully revised, new edition presenting latest developments in medical pharmacology Includes therapeutic guidelines from WHO and BNF Problem-directed study questions and key point summary boxes enhance learning Previous edition published in 2008

This dictionary of organic compounds should be of interest to chemists, biochemists, biologists and pharmacologists working within academic, industrial or governmental organizations.

Noting the need for clear and detailed information on Chinese herbal medicine, Jennes presents a volume (a reprint from 2004) for practitioners, students, pharmacologists, and researchers. He covers the potential for toxicity in general, types of interactions, and medicines that have been noted as harmful. The bulk of the book comprises 100 formulas and their medicinal components.Organized by Chinese name, the formulas are accompanied by information on potential for toxicity and interactions with other medicine, category, functions, indications, and dosage. Four indexes--by Pinyin formula, English forsmula, Pinyin herb, and Latin herb--are provided. The included CD-ROM is searchable by formula name, herb name, and class of Western drug. Jennes practices traditional Chinese medicine at a clinic in Colorado. Annotation ©2006 Book News, Inc., Portland, OR (booknews.com)

Traditional herbalists or wise women were not only good botanists or pharmacologists; they were also shamanic practitioners and keepers of occult knowledge about the powerful properties of plants. Traveling back to the healing arts of the ancient Egyptians, Greeks, and Romans, The Herbal Lore of Wise Women and Wortcunners takes readers deep into this world, through the leechcraft of heathen society and witches’ herb bundles to the cloister gardens of the Middle Ages. It also examines herbal medicine today in the traditional Chinese apothecary, the Indian ayurvedic system, homeopathy, and Native American medicine.   Balancing the mystical with the practical, author Wolf Storl explains how to become an herbalist, from collecting material to distilling and administering medicines. He includes authoritative advice on herb gardening, as well as a holistic inventory of plants used for purposes both benign and malign, from herbs for cooking, healing, beauty, and body care to psychedelic plants, witches’ salves for opening alternative realities, and poisonous herbs that can induce madness or cause death. Storl also describes traditional “women’s plants” and their uses: dyeing cloth, spinning and weaving, or whipping up love potions. The Herbal Lore of Wise Women and Wortcunners is written for professional and amateur herbalists as well as gardeners, urban homesteaders, and plantspeople interested in these rich ancient traditions.

Dr. Herbert West, The Reanimator, returns! Setting up shop in New Orleans, the brilliant Dr. West continues his life's work: the revival of the dead by purely chemical means. To accomplish this task, he recruits Susan Greene, a young and wide-eyed pharmacologist fascinated by his macabre experiments. Initially unfazed by West's unorthodox practices (including how he funds his research - by selling zombie brain fluid as a narcotic), Susan may regret her scientific curiosity as sinister forces - those aligned with Elder Gods and Haitian Voodoo - begin to align against the Reanimator. Dynamite Entertainment proudly resurrects H.P Lovecraft's notorious mad scientist in a fear-fraught tale of Cthulhu tentacle terror and backwater Louisianan superstition! Bonus features include a thorough "History of The Reanimator" prose introduction by writer Keith Davidsen, an insightful and meticulously researched appendix of Lovecraftian references and creator commentary, never-before-seen design illustrations from artist Randy Valiente, and a complete cover gallery featuring the work of Francesco Francavilla, Jae Lee, Andrew Mangum, Nacho Tenorio, and Tim Seeley.