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In eukaryotes many vital cellular functions like metabolism, motility, secretion, growth, differentiation are ultimately regulated by protein phosphorylation/dephosphorylation. Extracellular signals which trigger these changes control protein kinases and protein phosphatases. It is the aim of this volume to unveil signal networks which connect extracellular signals via second messengers with chages of the phosphorylation state of target proteins.

In eukaryotes many vital cellular functions like metabolism, motility, secretion, growth, differentiation are ultimately regulated by protein phosphorylation/dephosphorylation. Extracellular signals which trigger these changes control protein kinases and protein phosphatases. It is the aim of this volume to unveil signal networks which connect extracellular signals via second messengers with chages of the phosphorylation state of target proteins.

This volume provides an introduction to the general principles of neuromodulation--the key neurobiological process for understanding how the brain works. Emphasizing ion channels and biochemical mechanisms of protein phosphorylation, the book shows how neurons regulate their intracellular calcium concentration by modulating the activity of certain ion channels. It goes on to explain the function of intracellular calcium and describes some fascinating neuromodulatory phenomena in the mammalian brain that have long awaited the kind of mechanistic investigations possible in simpler systems. Bridging the gap between neurochemistry and neurophysiology, the authors make complex concepts and research approaches comprehensible to scientists in either field.

This volume provides an introduction to the general principles of neuromodulation--the key neurobiological process for understanding how the brain works. Emphasizing ion channels and biochemical mechanisms of protein phosphorylation, the book shows how neurons regulate their intracellular calcium concentration by modulating the activity of certain ion channels. It goes on to explain the function of intracellular calcium and describes some fascinating neuromodulatory phenomena in the mammalian brain that have long awaited the kind of mechanistic investigations possible in simpler systems. Bridging the gap between neurochemistry and neurophysiology, the authors make complex concepts and research approaches comprehensible to scientists in either field.

This accurate and up-to-date book focuses on the basic principles of Biochemistry, with carefully selected examples of each. The areas of greatest change since the second edition are lipid metabolism, oxidative phosphorylation, and protein metabolism. Includes stereo views of many macromolecules; computer supplement; a section on molecular evolution; protein structures; molecular evolution; and developments in the area of gene expression, including the structure of RNA polymerase, the structure of the ribosome, genome organization, repair mechanisms, regulation of transcription and translation, and the structure and evolution of aminoacy1-tRNA synthetases. For readers interested in Biochemistry.