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Would you change your genes if you could? As we confront the 'industrial revolution of the genome', the recent discoveries of Crispr-Cas9 technologies are offering, for the first time, cheap and effective methods for editing the human genome. This opens up startling new opportunities as well as significant ethical uncertainty. Tracing events across a fifty-year period, from the first gene splicing techniques to the present day, this is the story of gene editing - the science, the impact and the potential. Kozubek weaves together the fascinating stories of many of the scientists involved in the development of gene editing technology. Along the way, he demystifies how the technology really works and provides vivid and thought-provoking reflections on the continuing ethical debate. This updated paperback edition contains all the very latest on the patent battle over Crisp and the applications of Crispr technology in agriculture and medicine.

Would you change your genes if you could? As we confront the 'industrial revolution of the genome', the recent discoveries of Crispr-Cas9 technologies are offering, for the first time, cheap and effective methods for editing the human genome. This opens up startling new opportunities as well as significant ethical uncertainty. Tracing events across a fifty-year period, from the first gene splicing techniques to the present day, this is the story of gene editing - the science, the impact and the potential. Kozubek weaves together the fascinating stories of many of the scientists involved in the development of gene editing technology. Along the way, he demystifies how the technology really works and provides vivid and thought-provoking reflections on the continuing ethical debate. This updated paperback edition contains all the very latest on the patent battle over Crisp and the applications of Crispr technology in agriculture and medicine.

A leading bioethicist offers critical insights into the scientific, ethical, and political implications of human genome editing.Designer babies, once found only in science fiction, have become a reality. We are entering a new era of human evolution with the advent of a technology called CRISPR, which allows scientists to modify our genes. Although CRISPR shows great promise for therapeutic use, it raises thorny ethical, legal, political, and societal concerns because it can be used to make permanent changes to future generations. What if changes intended for the good turn out to have unforeseen negative effects? What if the divide between the haves and have-nots widens as a result? Who decides whether we genetically modify human beings and, if so, how?Françoise Baylis insists that we must all have a role in determining our future as a species. The scientists who develop and use genome-editing tools should not be the only ones making decisions about future uses of the technology. Such decisions must be the fruit of a broad societal consensus. Baylis argues that it is in our collective interest to assess and steer the development and implementation of biomedical technologies. Members of the public with different interests and diverse perspectives must be among the decision makers; only in this way can we ensure that societal concerns are taken into account and that responsible decisions are made. We must be engaged and informed, think critically, and raise our voices as we create our future together.Sharp, rousing, timely, and thought-provoking, Altered Inheritance is essential reading. The future of humanity is in our hands.

The latest edition of this highly successful textbook introduces the key techniques and concepts involved in cloning genes and in studying their expression and variation. The new edition features: Increased coverage of whole-genome sequencing technologies and enhanced treatment of bioinformatics. Clear, two-colour diagrams throughout. A dedicated website including all figures. Noted for its outstanding balance between clarity of coverage and level of detail, this book provides an excellent introduction to the fast moving world of molecular genetics.

The latest edition of this highly successful textbook introduces the key techniques and concepts involved in cloning genes and in studying their expression and variation. The new edition features: Increased coverage of whole-genome sequencing technologies and enhanced treatment of bioinformatics. Clear, two-colour diagrams throughout. A dedicated website including all figures. Noted for its outstanding balance between clarity of coverage and level of detail, this book provides an excellent introduction to the fast moving world of molecular genetics.

While the complete sequencing of the genomes of model organisms such as a multitude of bacteria and archaea, the yeast Saccharomyces cerevisiae, the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the mouse and human genomes have received much public attention, the deciphering of plant genomeswas greatly lagging behind. Up to now, only two plant genomes, one of the model plant Arabidopsis thaliana and one of the crop species rice (Oryza sativa) have been sequenced, though a series of other crop genome sequencing projects are underway. Notwithstanding this public bias towards genomics of animals and humans, it is nevertheless of great importance for basic and applied sciences and industries in such diverse fields as agriculture, breeding in particular, evolutionary genetics, biotechnology, and food science to know the composition of crop plant genomes in detail. It is equally crucial for a deeper understanding of the molecular basis of biodiversity and synteny. The Handbook of Genome Mapping: Genetic and Physical Mapping is the first book on the market to cover these hot topics in considerable detail, and is set apart by its combination of genetic and physical mapping. Throughout, each chapter begins with an easy-to-read introduction, also making the book the first reference designed for non-specialists and newcomers, too. In addition to being an outstanding bench work reference, the book is an excellent textbook for learning and teaching genomics, in particular for courses on genome mapping. It also serves as an up-to-date guide for seasoned researchers involved in the genetic and physical mapping of genomes, especially plant genomes.

Plant Genes, Genomes and Genetics provides a comprehensive treatment of all aspects of plant gene expression. Unique in explaining the subject from a plant perspective, it highlights the importance of key processes, many first discovered in plants, that impact how plants develop and interact with the environment. This text covers topics ranging from plant genome structure and the key control points in how genes are expressed, to the mechanisms by which proteins are generated and how their activities are controlled and altered by posttranslational modifications. Written by a highly respected team of specialists in plant biology with extensive experience in teaching at undergraduate and graduate level, this textbook will be invaluable for students and instructors alike. Plant Genes, Genomes and Genetics also includes: specific examples that highlight when and how plants operate differently from other organisms special sections that provide in-depth discussions of particular issues end-of-chapter problems to help students recapitulate the main concepts rich, full-colour illustrations and diagrams clearly showing important processes in plant gene expression a companion website with PowerPoint slides, downloadable figures, and answers to the questions posed in the book Aimed at upper level undergraduates and graduate students in plant biology, this text is equally suited for advanced agronomy and crop science students inclined to understand molecular aspects of organismal phenomena. It is also an invaluable starting point for professionals entering the field of plant biology.

Plant Genes, Genomes and Genetics provides a comprehensive treatment of all aspects of plant gene expression. Unique in explaining the subject from a plant perspective, it highlights the importance of key processes, many first discovered in plants, that impact how plants develop and interact with the environment. This text covers topics ranging from plant genome structure and the key control points in how genes are expressed, to the mechanisms by which proteins are generated and how their activities are controlled and altered by posttranslational modifications. Written by a highly respected team of specialists in plant biology with extensive experience in teaching at undergraduate and graduate level, this textbook will be invaluable for students and instructors alike. Plant Genes, Genomes and Genetics also includes: specific examples that highlight when and how plants operate differently from other organisms special sections that provide in-depth discussions of particular issues end-of-chapter problems to help students recapitulate the main concepts rich, full-colour illustrations and diagrams clearly showing important processes in plant gene expression a companion website with PowerPoint slides, downloadable figures, and answers to the questions posed in the book Aimed at upper level undergraduates and graduate students in plant biology, this text is equally suited for advanced agronomy and crop science students inclined to understand molecular aspects of organismal phenomena. It is also an invaluable starting point for professionals entering the field of plant biology.

This item is printed on demand - it takes 3-4 days longer - Neuware -In scholarly digital editing, the established practice for semantically enriching digital texts is to add markup to a linear string of characters. Graph data-models provide an alternative approach, which is increasingly being given serious consideration. Labelled-property-graph databases, and the W3c's semantic web recommendation and associated standards (RDF and OWL) are powerful and flexible solutions to many of the problems that come with embedded markup. This volume explores the combination of scholarly digital editions, the graph data-model, and the semantic web from three perspectives: infrastructures and technologies, formal models, and projects and editions. 224 pp. Englisch

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Prepping your established planting bed, vegetable garden or weeding around your existing plants is made easier with the Troy-Bilt 2-cycle 9 in. gas cultivator. The adjustable 6 in. to 9 in. cultivating width adds flexibility to tackle a variety of tasks and the durable gear-drive transmission is dependable and powerful to handle the toughest of applications. Manage light landscaping, weeding and cultivating projects all year long with four, premium, forward-rotating 8 in. steel tines which let you prepare established beds, maintain summer gardens and turn under vegetation in the fall. The cultivator is lightweight and compact for easy transport and storage when in between uses. Lightweight and easy to operate, the TB225 garden cultivator is the must-have tool.

A Performance Series 8GB DDR4 2666MHz SO-DIMM Notebook Memory Module from PNY is the ideal solution for those seeking enhanced speed and reliability for their Windows notebook PCs. This high-quality memory upgrade is designed to handle memory-intensive applications such as graphic design and video-editing tools with ease, making it perfect for both professional and personal use. Whether you're a multitasker who likes to keep numerous browser windows open or a power user whose PC struggles to keep up with demanding tasks, this DDR4 2666MHz memory upgrade is designed to optimize your computing experience. As part of PNY's Performance line, this DDR4 RAM module offers not only rock-solid reliability but also exceptional value, making it a smart choice for users seeking to enhance their PC's performance.With over 30 years of experience in sourcing, testing, and manufacturing memory upgrades for a wide range of popular PC platforms, PNY is a trusted name in the industry. This DDR4 2666MHz upgrade is no exception, offering faster speeds, greater bandwidth, and lower power consumption for a noticeable improvement in PC response times during memory-intensive application use.Moreover, the PNY DDR4 memory modules are engineered and rigorously tested to ensure stable, reliable performance in real-world computing environments. They also feature enhanced thermal performance, contributing to the longevity and efficiency of your PC. In essence, with a DDR4 2666MHz upgrade from PNY, you're investing in a faster, more efficient, and more reliable computing experience.

Add dazzling impact and style to your home’s exterior accents with BEHR MARQUEE Semi-Gloss Enamel Exterior paint. Featuring the most advanced dirt and fade technology available from BEHR that keeps your home looking freshly painted longer. This radiant, durable sheen provides a perfectly polished look, vivid color to trim, windows and doors, including garage doors, as well as shutters and outdoor furniture. It’s also great for surfaces like railings and wrought iron. Color: Aloe Plant.

For a classic, cultivated look on your home's exterior walls, choose BEHR MARQUEE Flat Exterior paint. Featuring the most advanced dirt and fade technology available from BEHR that keeps your home looking freshly painted longer. This gorgeous low-lustre sheen minimizes minor surface imperfections to bring out the best in wood and vinyl siding as well as brick, stucco and other masonry. Color: Aloe Plant.

Add dazzling impact and style to your home’s exterior accents with BEHR MARQUEE Satin Enamel Exterior paint. Featuring the most advanced dirt and fade technology available from BEHR that keeps your home looking freshly painted longer. This radiant, durable sheen provides a perfectly polished look, vivid color to trim, windows and doors, including garage doors, as well as shutters and outdoor furniture. It’s also great for surfaces like railings and wrought iron. Color: Aloe Plant.

For a classic, cultivated look on your home’s exterior walls, choose BEHR MARQUEE Flat Exterior paint. Featuring the most advanced dirt and fade technology available from BEHR that keeps your home looking freshly painted longer. This gorgeous low-lustre sheen minimizes minor surface imperfections to bring out the best in wood and vinyl siding as well as brick, stucco and other masonry. Color: Healing Plant.

Add dazzling impact and style to your home’s exterior accents with BEHR MARQUEE Semi-Gloss Enamel Exterior paint. Featuring the most advanced dirt and fade technology available from BEHR that keeps your home looking freshly painted longer. This radiant, durable sheen provides a perfectly polished look, vivid color to trim, windows and doors, including garage doors, as well as shutters and outdoor furniture. It’s also great for surfaces like railings and wrought iron. Color: Aloe Plant.

For a classic, cultivated look on your home’s exterior walls, choose BEHR MARQUEE Flat Exterior paint. Featuring the most advanced dirt and fade technology available from BEHR that keeps your home looking freshly painted longer. This gorgeous low-lustre sheen minimizes minor surface imperfections to bring out the best in wood and vinyl siding as well as brick, stucco and other masonry. Color: Aloe Plant.

Add dazzling impact and style to your home’s exterior accents with BEHR MARQUEE Satin Enamel Exterior paint. Featuring the most advanced dirt and fade technology available from BEHR that keeps your home looking freshly painted longer. This radiant, durable sheen provides a perfectly polished look, vivid color to trim, windows and doors, including garage doors, as well as shutters and outdoor furniture. It’s also great for surfaces like railings and wrought iron. Color: Aloe Plant.

Add dazzling impact and style to your home’s exterior accents with BEHR MARQUEE Semi-Gloss Enamel Exterior paint. Featuring the most advanced dirt and fade technology available from BEHR that keeps your home looking freshly painted longer. This radiant, durable sheen provides a perfectly polished look, vivid color to trim, windows and doors, including garage doors, as well as shutters and outdoor furniture. It’s also great for surfaces like railings and wrought iron. Color: Healing Plant.