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Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic bi

Synthetic materials are a tremendous potential resource for treating human disease. For the rational design of many of these biomaterials it is necessary to have an understanding of polymer chemistry and polymer physics. Equally important to those two fields is a quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological and pathological situations. This book is a synthesis of these principles, providing a working foundation for those in the field of drug delivery. It covers advanced drug delivery and contemporary biomaterials.

The detection and evaluation of adverse drug reactions is crucial for understanding the safety of medicines and for preventing harm in patients. Not only is it necessary to detect new adverse drug reactions, but the principles and practice of pharmacovigilance apply to the surveillance of a wide range of medicinal products. Stephens' Detection and Evaluation of Adverse Drug Reactions provides a comprehensive review of all aspects of adverse drug reactions throughout the life cycle of a medicine, from toxicology and clinical trials through to pharmacovigilance, risk management, and legal and regulatory requirements. It also covers the safety of biotherapeutics and vaccines and includes new chapters on pharmacogenetics, proactive risk management, societal considerations, and the safety of drugs used in oncology and herbal medicines. This sixth edition of the classic text on drug safety is an authoritative reference text for all those who work in pharmacovigilance or have an interest in adverse drug reactions, whether in regulatory authorities, pharmaceutical companies, or academia. Praise for previous editions "This book presents a comprehensive and wide-ranging overview of the science of pharmacovigilance. For those entering or already experienced in the pharmaceutical sciences, this is an essential work.” - from a review in E-STREAMS "...a key text in the area of pharmacovigilance...extensively referenced and well-written...a valuable resource..." - from a review in The Pharmaceutical Journal

This primary textbook for a first course in pharmacology offers an integrated, systems-based, and mechanism-based approach to understanding drug therapy. Each chapter focuses on a target organ system, begins with a clinical case, and incorporates cell biology, biochemistry, physiology, and pathophysiology to explain how and why different drug classes are effective for diseases in that organ system. Over 400 two-color illustrations show molecular, cellular, biochemical, and pathophysiologic processes underlying diseases and depict targets of drug therapy. Each Second Edition chapter includes a drug summary table presenting mechanism, clinical applications, adverse effects, contraindications, and therapeutic considerations. New chapters explain how drugs produce adverse effects and describe the life cycle of drug development. The fully searchable online text and an image bank are available on thePoint.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product.An essential text for any Pharmacy Research Design/Drug Literature coursePrinciples of Research Design and Drug Literature Evaluation, Second Edition is a unique resource that provides a balanced approach covering critical elements of clinical research, biostatistical principles, and scientific literature evaluation techniques for evidence-based medicine. It is the ideal foundation for professional pharmacy students and a key resource for pharmacy residents, research fellows, practitioners, and clinical researchers.This highly accessible text provides comprehensive course content that meets or exceeds the curriculum standards set forth by the Accreditation Council for Pharmacy Education (ACPE). Written by expert authors specializing in pharmacy practice and research, this valuable text will provide pharmacy students and practitioners with a thorough understanding of the principles and practices of drug literature evaluation with a strong grounding in research and biostatistical principles.

Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property."Provides a clear explanation of how the pharmaceutical industry works Explains the complete drug discovery process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual propertyIdeal for anyone interested in learning about the drug discovery process and those contemplating careers in the industry Explains the transition process from academia or other industries

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This new edition was recognized as a highly commended title by the British Medical Association at the 2017 BMA Medical Book Awards . Regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th Edition , offers an integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps first- and second-year students grasp challenging concepts quickly and efficiently. Each chapter presents a clinical vignette illustrating a therapeutic problem within a physiologic or biochemical system; followed by a discussion of the biochemistry, physiology, and pathophysiology of the system; and concluding with a presentation of the pharmacology of the drugs and drug classes that activate or inhibit the system by interacting with specific molecular and cellular targets. Chapters are integrated into sections that focus on organ systems and therapeutic areas of highest importance. Clear, concise illustrations highlight key points, and drug summary tables offer quick access to essential information.The Fourth Edition features:Comprehensive updates to all chapters, including recently approved drugsNearly 40 popular and practical Drug Summary Tables with state-of-the-art information on clinical applications, serious and common adverse effects, contraindications, and therapeutic considerationsA new chapter on drug transporters , and extensively revised information on drug-receptor interactions, pharmacodynamics, drug toxicity, and pharmacogenomicsKey changes to Section 1: Fundamental Principles of Pharmacology, which now provides a comprehensive framework for material in all subsequent chaptersHundreds of meticulously updated and colorized illustrations , including many that are new or substantially modified to highlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms

Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generation drugs, the book evaluates the technology as a whole and offers new directions and avenues of research and development. Divided into five parts, the book begins with a thorough introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucleotides. Leading researchers demonstrate the basics of oligonucleotide therapeutics in part two by delineating medicinal chemistry, pharmacokinetics, and delivery routes such as liposomal formulations for nucleic acid delivery.  Part three details hybridization based drugs and considers the dramatic advances represented by 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA drugs. Other chemical classes of drugs and mechanisms of action are described in part four with further discussions on improving the second generation antisense drugs. The final part delves deeply into therapeutic applications. Contributing authors examine the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation. Presenting a highly detailed, lucid discussion of the remarkable advances in the field, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition provides the platform for researchers to continue to aggressively pursue the great opportunity represented by this exciting technology.

This new edition was recognized as a highly commended title by the British Medical Association at the 2017 BMA Medical Book Awards . Regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th Edition , offers an integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps first- and second-year students grasp challenging concepts quickly and efficiently. Each chapter presents a clinical vignette illustrating a therapeutic problem within a physiologic or biochemical system; followed by a discussion of the biochemistry, physiology, and pathophysiology of the system; and concluding with a presentation of the pharmacology of the drugs and drug classes that activate or inhibit the system by interacting with specific molecular and cellular targets. Chapters are integrated into sections that focus on organ systems and therapeutic areas of highest importance. Clear, concise illustrations highlight key points, and drug summary tables offer quick access to essential information.The Fourth Edition features:Comprehensive updates to all chapters, including recently approved drugsNearly 40 popular and practical Drug Summary Tables with state-of-the-art information on clinical applications, serious and common adverse effects, contraindications, and therapeutic considerationsA new chapter on drug transporters , and extensively revised information on drug-receptor interactions, pharmacodynamics, drug toxicity, and pharmacogenomicsKey changes to Section 1: Fundamental Principles of Pharmacology, which now provides a comprehensive framework for material in all subsequent chaptersHundreds of meticulously updated and colorized illustrations , including many that are new or substantially modified to highlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms

This new edition was recognized as a highly commended title by the British Medical Association at the 2017 BMA Medical Book Awards . Regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th Edition , offers an integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps first- and second-year students grasp challenging concepts quickly and efficiently. Each chapter presents a clinical vignette illustrating a therapeutic problem within a physiologic or biochemical system; followed by a discussion of the biochemistry, physiology, and pathophysiology of the system; and concluding with a presentation of the pharmacology of the drugs and drug classes that activate or inhibit the system by interacting with specific molecular and cellular targets. Chapters are integrated into sections that focus on organ systems and therapeutic areas of highest importance. Clear, concise illustrations highlight key points, and drug summary tables offer quick access to essential information.The Fourth Edition features:Comprehensive updates to all chapters, including recently approved drugsNearly 40 popular and practical Drug Summary Tables with state-of-the-art information on clinical applications, serious and common adverse effects, contraindications, and therapeutic considerationsA new chapter on drug transporters , and extensively revised information on drug-receptor interactions, pharmacodynamics, drug toxicity, and pharmacogenomicsKey changes to Section 1: Fundamental Principles of Pharmacology, which now provides a comprehensive framework for material in all subsequent chaptersHundreds of meticulously updated and colorized illustrations , including many that are new or substantially modified to highlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms

"The perfect handbook for the clinical supervisor." ―Nancy Waite-O’Brien, director, Education and Training, Betty Ford Center "An outstanding contribution to the professional well-being of the addiction field." ―Thomas McGovern, editor, Addiction Treatment Quarterly "Forever useful." ―S. Beckett, education and training coordinator, National Association of Alcohol and Drug Abuse Counselors

As every healthcare provider knows, drug-drug interactions are as prevalent as they are preventable. The Clinical Manual of Drug Interaction Principles for Medical Practice is an exceptionally practical, thoroughly up-to-date resource to help psychiatric clinicians (including residents and nurses) understand and avoid potentially dangerous interactions and provide the highest standard of patient care. Many new medications have entered the market in recent years and knowledge of pharmacokinetics and pharmacogenetics has grown significantly. From earlier versions in concise guide format, the authors have evolved this new and enlarged Manual offering the expanded coverage and features that clinicians need to keep up with this critical field. Major sections cover metabolism (with new, expanded coverage of transporters); cytochrome P450 enzymes; up-to-date coverage of drug interactions by medical specialty; and practical matters, such as the medicolegal implications of drug-drug interactions and how to retrieve and review the literature. Each chapter includes extensive references and study cases to help the reader understand and contextualize the information. A summary table of drugs by specialty and their metabolic sites provides ready reference. The book s comprehensive coverage reflects the very latest research, and its user-friendly format will make it indispensable to anyone engaged in direct patient care.

This new edition was recognized as a highly commended title by the British Medical Association at the 2017 BMA Medical Book Awards . Regarded by both students and instructors, Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy, 4th Edition , offers an integrated mechanism-based and systems-based approach to contemporary pharmacology and drug development. An easy-to-follow format helps first- and second-year students grasp challenging concepts quickly and efficiently. Each chapter presents a clinical vignette illustrating a therapeutic problem within a physiologic or biochemical system; followed by a discussion of the biochemistry, physiology, and pathophysiology of the system; and concluding with a presentation of the pharmacology of the drugs and drug classes that activate or inhibit the system by interacting with specific molecular and cellular targets. Chapters are integrated into sections that focus on organ systems and therapeutic areas of highest importance. Clear, concise illustrations highlight key points, and drug summary tables offer quick access to essential information.The Fourth Edition features:Comprehensive updates to all chapters, including recently approved drugsNearly 40 popular and practical Drug Summary Tables with state-of-the-art information on clinical applications, serious and common adverse effects, contraindications, and therapeutic considerationsA new chapter on drug transporters , and extensively revised information on drug-receptor interactions, pharmacodynamics, drug toxicity, and pharmacogenomicsKey changes to Section 1: Fundamental Principles of Pharmacology, which now provides a comprehensive framework for material in all subsequent chaptersHundreds of meticulously updated and colorized illustrations , including many that are new or substantially modified to highlight new understanding of physiologic, pathophysiologic, and pharmacologic mechanisms

This groundbreaking work, now available in paperback, is the standard text for the training and education of supervisors in substance abuse counseling. The blended model of treatment presented here is a synthesis of several established schools of therapy, and utilizes developmental, psychodynamic skills, and family therapy perspectives. Firmly grounded in both theory and practice, this book offers methods of supervisory contracting, observation, case presentation, modeling, intervention, and evaluation. Ethical and legal concerns are also addressed. Clinical Supervision provides the knowledge base that substance abuse supervisors will need in the coming years.

Unlike other pharmacology texts organized by drug class, Principles of Pharmacology integrates relevant knowledge from the basic biomedical sciences - physiology, pathophysiology, cell and molecular biology, biochemistry, anatomy, neurobiology, microbiology and immunology - to build an integrated, conceptual understanding of drug therapy. By discussing the therapeutic and adverse actions of drugs in the framework of the drug's mechanism of action, the book enables students to achieve a level of mastery in pharmacology that far surpasses that achieved by rote memorization. The result is a primary pharmacology textbook that is ideal for a systems-based or discipline-based course in pharmacology.

Useful for psychiatrists, residents, and medical students, this pocket (4.25x6.5<">) guide presents a broad view of pharmacokinetic drug interactions, and includes a separate guide with tables of drug interaction principles. For this second edition, material on phase I and phase II metabolism has been expanded, and there are new chapters on P-glycoproteins, minor P450 enzymes, and analgesics. Cozza is a psychiatrist affiliated with Walter Reed Army Medical Center. Annotation (c) Book News, Inc., Portland, OR (booknews.com)

This groundbreaking work, now available in paperback, is the standard text for the training and education of supervisors in substance abuse counseling. The blended model of treatment presented here is a synthesis of several established schools of therapy, and utilizes developmental, psychodynamic skills, and family therapy perspectives. Firmly grounded in both theory and practice, this book offers methods of supervisory contracting, observation, case presentation, modeling, intervention, and evaluation. Ethical and legal concerns are also addressed. Clinical Supervision provides the knowledge base that substance abuse supervisors will need in the coming years.