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This volume is a new edition of the most authoritative book on Prion Biology, first published in 1999 and edited by the Nobel Prize-winning founder of the field. This expanded edition has been completely updated, and includes chapters on therapeutics, and diagnostic methods and approaches.

This volume details protocols on prion disease from multiple disciplines and highlights the contribution each discipline has made to the understanding of prion disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Prions: Methods and Protocols aims to ensure successful results in the further study of this vital field.

This volume provides comprehensive information and detailed laboratory protocols used in the study of prion diseases. The chapters in this book cover topics such as: electron microscopy, neuropathology, immunohistochemistry, and immune-gold electron microscopy of prion diseases. Chapters also provide readers with detailed information about kuru, the clinical description of prion diseases, and the detection of prion protein and biomarkers. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Cutting-edge and authoritative, Prion Diseases is a valuable resource for researchers and scientists in the exciting and rapidly growing field of prion disease research.

A series of remarkable discoveries in the past three decades have led to the molecular and genetic characterization of the transmissible pathogen causing scrapie in animals and a quartet of human illnesses: kuru, Jakob-Creutzfeld disease, Gerstmann-Sträussler-Scheinker disease, and fatal familial insomnia. To distinguish this pathogen from viruses and viroids, the term "prion" was introduced to emphasize its proteinaceous and infectious nature.Stanley B. Prusiner, editor of this volume, was awarded the 1997 Nobel Prize in Physiology and Medicine for his pioneering discovery of prions. The book reviews advances in studies of prions, which - as considereable evidence indicates - are novel pathogens composed only of protein.

This volume details protocols on prion disease from multiple disciplines and highlights the contribution each discipline has made to the understanding of prion disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Prions: Methods and Protocols aims to ensure successful results in the further study of this vital field.

This volume is a new edition of the most authoritative book on Prion Biology, first published in 1999 and edited by the Nobel Prize-winning founder of the field. This expanded edition has been completely updated, and includes chapters on therapeutics, and diagnostic methods and approaches.

This volume provides comprehensive information and detailed laboratory protocols used in the study of prion diseases. The chapters in this book cover topics such as: electron microscopy, neuropathology, immunohistochemistry, and immune-gold electron microscopy of prion diseases. Chapters also provide readers with detailed information about kuru, the clinical description of prion diseases, and the detection of prion protein and biomarkers. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Cutting-edge and authoritative, Prion Diseases is a valuable resource for researchers and scientists in the exciting and rapidly growing field of prion disease research.

Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired formsProvides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humansEmphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Unread book in perfect condition.

Originally written for Debrett's Peerage, Douglas Sutherland's guide to that endangered species, the English Gentleman, was composed as an antidote to all the dull little books on manners. Both genuinely informative and very amusing, The English Gentleman offers the parvenu a window onto the world of the genuine article. It describes his habits, where he might live, what he might wear, his school, his clubs, his hobbies and sports, his family and relationships, his mode of speech, and the acceptable way to behave in almost any given situation. Not to mention advice on the correct attitudes toward money (it's vulgar), sex (it's vulgar), and business (it's vulgar unless, of course, it's run at a heavy loss). This is a hilarious initiation into the eccentric world of the stiff upper lip.

Despite its bleak title, Doom is William Gerhardie's most wildly funny novel. It is the story of Frank Dickin, an impoverished young novelist, and his involvement, on the one hand, with an eccentric family of Russian émigrés—in particular, their beautiful daughter Eva—and, on the other, with an all-powerful newspaper magnate, Lord Ottercove, who takes Dickin on as a lost cause. This irrepressible comic potpourri also involves a mad English lord who is bent on destroying the world, and with an outrageous sleight of hand that only Gerhardie could manage, the novel slowly slips from social comedy toward apocalypse.

Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired formsProvides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humansEmphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Daniel Skipton is a Pioneer in Art. He’s also a rogue who hasn’t done an honest day’s work in his life. Instead, he bullies support out of aging relatives he’s never met and harangues his publisher for advances on non-existent projects. The world owes Skipton a living, but it doesn’t want to pay up. Outraged by life and choked with anger, our self-proclaimed literary genius lives by his wits in the Belgian city of Bruges. Along with a pack of disreputable allies among them, Wouvermans the antiques dealer” and Mimi the performance artist” he swindles a group of naïve English tourists into unwittingly supporting his meager lifestyle. As Ruth Rendell makes clear in her introduction, The Unspeakable Skipton is a wickedly funny sketch of the artist at his worst.

Mrs. Emmeline Lucas is the recently-widowed newcomer to the village of Tilling, eager to wrest the reins of social supremacy from the incumbent Miss Elizabeth Mapp and to install herself as its benevolent dictator. In their polite acts of sabotage, as they ruthlessly jockey for the position of cultural arbiter, Mapp and Lucia tear up the conventions of drawing-room diplomacy and enter a protracted conflict using fêtes, garden parties, musical soirées, and bridge evenings as their deadly weapons. Things finally come to a head with Miss Mapp's audacious attempt to steal her rival's celebrated recipe for Lobster à la Riseholme. With a charming satirical bent, E.F. Benson turns the pretensions and snobberies of English village life into a deliciously wicked comedy.

The humorous adventures of Hyman Kaplan, the irrepressible student at the american Night Preparatory School for Adults, and his personal war with the English language. A classic work of american humor.

A readable copy of the book which may include some defects such as highlighting and notes. Cover and pages may be creased and show discolouration.

Three hundred letters, edited and translated by a leading Napoleonic scholar, offer a direct insight into the mind of one of the greatest soldiers and most interesting figures in history. During his lifetime, Napoleon wrote 60,000 letters, 41,000 of which still survive. This collection, first published in the 1930s and out of print for decades, includes 300 letters edited and translated by eminent Oxford scholar J.M. Thompson. The letters span Napoleon's entire career, from 15-year-old artillery trainee to Emperor in exile. They range from the most precise military instruction, to teasing correspondence with the Empress Josephine, to far-sighted discussions of the principles of government and the education of women. In these letters, Napoleon is revealed in all his guises: wise, clear-sighted, abusive, bullying, charming, eloquent, and heroic.

H.M. Bateman’s marvelously funny cartoons brought him international fame during the middle years of the 20th century, and the very best of his work still represents a timeless comic legacy. Bateman was most celebrated for his The Man Who ” cartoons a series featuring hilarious social gaffes in which some lonely figure commits a ghastly faux pas to the amazement or outrage of the assembled onlookers. Indeed, the English obsession with class, etiquette, and order is at the heart of much of his humor. This book now brings together the very best of Bateman’s work in a single volume.

At a time when military commanders in Europe were royal princes and dukes, Napoleon's marshals were often the sons of peasants or clerks. And they were usually half the age of their opponents—whom they thrashed soundly with almost monotonous regularity. This is the story of Ney, Murat, Soult, Davout, Bernadotte, Massena, Lannes, Marmont, and Augereau. It took, for instance, only 23 days for the entire Prussian army to be defeated and one of the French marshals, Augereau, had the pleasure of taking prisoner the feared Prussian Guards, a regiment he had deserted 20 years earlier in order to become a dancing master. A.G. Macdonell is also the author of England, their England.

The tales that make up Seven Men and Two Others start out as a set of "faux" memoirs set amid London literary life in the precious fin de siècle era and proceed into deliciously absurd fantasy. With a sense of fun, a hint of nostalgia, razor-sharp satire, and pitch-perfect parody, Beerbohm tugs at the affected nature of the whole literary scene—lamentable authors, wily agents, and preposterous weekend salons.