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This important publication addresses the interactions of proteins with nonspecific binding sites on DNA as they play critical roles in fundamental cellular processes such as transcription, DNA replication, and recombination. The book presents current reviews of the biochemistry of representative nonspecific DNA-protein systems, and of their physiological functions. It includes chapters on the techniques used to characterize the complexes, on their thermodynamic properties, and on the role of nonspecific binding as gene regulatory proteins search for specific target sites on the chromosome. Systems considered include the effects of nonspecific binding in regulation of the lactose operon of Escherichia coli, the T4 bacteriophage gene 32 protein, the E. coli single strand binding (SSB) protein and recA protein, eukaryotic SSB's and histone-DNA complexes. The book presents those proteins displaying multiple modes of DNA binding as participants in more than one cellular process. This monograph combines rigorous descriptions of new findings for these important systems with provocative interpretations of the biological significance of the results. It is of great value to researchers ranging from graduate students to senior scientists in the areas of biochemistry, microbiology and molecular/cell biology.

One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein-DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create unified view of the field and a fuller understanding of protein-DNA interactions.

The study of the interactions of proteins, whether they be enzymes, regulatory proteins or structural proteins, with nucleic acids is one of the most exciting areas of modern molecular biology. In this 1993 text, Professor Steitz reviews the wide-ranging research in structural studies of DNA-binding proteins and their complexes with DNA. The author clearly and concisely describes the uses of techniques in molecular genetics, DNA synthesis, protein crystallography and nuclear magnetic response. The book, by a now Nobel Prize-winning author, will continue to be enjoyed by anyone with an interest in this exciting area of research.

One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein-DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create unified view of the field and a fuller understanding of protein-DNA interactions.

Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Focuses on protein allostery in drug discoveryDraws together the study of protein structure/function and the study of allosteryContributed by experts in this field Dr. Jian Zhang is Professor at Shanghai Jiao Tong Univ.

The kidney plays a crucial role in the metabolism of many low molecular weight proteins. Many drugs and chemicals can injure the kidney and cause an increase in urinary proteins and enzymes. This publication reports the latest findings from experimental and clinical medicine on the renal handling of proteins and the nephrotoxicity of drugs and contrast media. Other areas of interest include renal physiology and pathophysiology, proteinuria, and the importance of urinary proteins and enzymes in the detection of kidney damage.

Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs defines biotechnology from the perspective of pharmaceuticals. The first section focuses on the process of transforming a biologic macromolecule into a therapeutic agent, while the second section provides a brief overview of each class of macromolecule with respect to physiological role and clinical application. Additional detail is also provided in the second section for each FDA approved, recombinantly derived biopharmaceutical for each category of macromolecule. The final section looks to the future and the new advances that will enhance our ability to develop new macromolecules into effective biopharmaceuticals. This last section discusses various drug delivery strategies while also describing gene and cell therapy strategies.

Brand from South Korea: Dr. Groot. Benefits:An anti-hairloss protein treatment that coats and nourishes dry and frizzy hair.Formulated with functional anti-hairloss care ingredients recognized by the South Korea Ministry of Food and Drug Safety like Salicylic Acid, Panthenol, and Niacinamide. Enriched with 8 types in ingredients formulated with patented scalp and hair nourishment and strengthening technologies.Contains Biotin capsules with exclusive technologies that increases the absorption rate to up to 2.9 times.Infused with Micro Proteins with 17 types of Amino Acids and ultra small molecular Collagen to keep hair soft and elastic.How to use:Apply an appropriate amount on wet hair and scalp and gently massage. Rinse off with lukewarm water.

This practical guide offers concise coverage of the scientific and pharmaceutical aspects of protein delivery from controlled release microparticulate systems-emphasizing protein stability during encapsulation and release.

This textbook provides a structured, easy to understand and thorough insight into the mode of function of plant secondary metabolites in plants and humans. It explains the biosynthesis and molecular action of nicotine, cannabis, caffeine and Co, describes the effects of these drugs on signal transduction at receptors and ion channels in animals, their relevance for human health and their potential for recreational use and abuse. It also offers a broad and comprehensive understanding on the role and function of these diverse molecules for the plants that make them. This textbook is written for master students and scientist in biochemistry and biology as well as for pharmaceutical and medical students. It will be a valuable study tool for teachers and students alike.

Useful for psychiatrists, residents, and medical students, this pocket (4.25x6.5<">) guide presents a broad view of pharmacokinetic drug interactions, and includes a separate guide with tables of drug interaction principles. For this second edition, material on phase I and phase II metabolism has been expanded, and there are new chapters on P-glycoproteins, minor P450 enzymes, and analgesics. Cozza is a psychiatrist affiliated with Walter Reed Army Medical Center. Annotation (c) Book News, Inc., Portland, OR (booknews.com)

Drug–Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug–drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug–drug interactions, the prediction of drug–drug interaction potential of new drugs, and the avoidance of clinically significant drug–drug interaction in patients.Provides useful references on the science of drug-drug interactionsDescribes in a basic and comprehensive manner drug-drug interactions from the mechanistic viewpointContains original data from academic and industrial laboratoriesPresents an overview of regulatory agency positions

Stockley’s Drug Interactions, edited by Claire L Preston, remains the world’s most comprehensive and authoritative international reference book on drug interactions. Based upon thousands of published papers and reports it: * Covers interactions between therapeutic drugs, proprietary medicines, herbal medicines, foods, drinks, and drugs of abuse * Contains in-depth yet concise monographs in an easy-to-read format * Provides comprehensive details of the clinical evidence for the interactions under discussion, an assessment of their clinical importance, and clear guidance on managing the interaction in practice * Has a brief summary of the interaction in each monograph – perfect for the busy healthcare professional * Is fully referenced throughout * Is global in coverage New in the 12th edition are over 300 new monographs, with reviews and updates for the existing 4500 monographs.

This book addresses the rise in patients use of herbal medications with traditional prescribed drugs by warning against combinations that may cause health problems. Over 1,000 references in books and medical journals given.

Discover the Dangers and Benefits of Drug-Herb-Vitamin InteractionsAre you aware that mixing certain drugs, herbs, and vitamins can benefit your health, whereas other combinations are downright dangerous? It's true. With the right vitamin or herb you can reduce or even eliminate certain side effects of over-the-counter or prescription medications. On the other hand, taking the wrong vitamin or herb can increase some side effects or interfere with the effectiveness of your medication. This book can help you to be sure! Inside, you'll learn how to reduce the risk of hazardous interactions. You'll also discover exactly which supplements to take to enhance the effectiveness of your medications. Every statement is based on the latest scientific research and is rigorously reviewed for accuracy by a medical doctor and a professor of pharmacology. Balanced and trustworthy, this book includes: ·Detailed descriptions of drugs, herbs, and vitamins and their uses ·A comprehensive guide to both negative and positive combinations ·Easy reference to specific drug-herb-vitamin interactions ·And much more! This is the essential reference for anyone taking vitamins, minerals, or herbs with over-the-counter or prescription medications.

This book's first edition (1997) was the first of its kind in addressing herbal interactions with drugs. This 4th edition keeps current with research findings and scrupulously distinguishes between what is known through (1) empirical clinical observations such as case reports, (2) data obtained from modern clinical human studies, (3) different types of laboratory research on animals and with tissues and cells. Over 2700 medical and scientific sources are cited to document these findings. In addition, the type of preparation studied is described to emphasize differences between preparations from the same herb, along with dosage size and duration. Conflicting results are utilized to put these issues in context. This fourth edition further highlights those combinations of herbal preparations with drugs shown to beneficially enhance therapeutic activity or reduce adverse effects, identified for 98 of the 321 herbs listed in the main text. In addition, extensive appendices organize information on these 321 and additional herbal remedies into categories addressing specific cautions, interactions with particular types of drugs, precautions for mothers, infants and children, drug interactions with vitamins and minerals, and advantageous combinations with medicines used for inflammations, infections, cancer, and for addressing substance abuse. The appendix sections addressing herbal influences on drug absorption and metabolism involving transport proteins, cytochrome P450 isoenzymes, and conjugating enzymes are the most extensive compilations available anywhere.

This book addresses the rise in patients use of herbal medications with traditional prescribed drugs by warning against combinations that may cause health problems. Over 1,000 references in books and medical journals given.

...useful for those who wish to avoid complicating a patient's current condition or treatment by prescribing botanics in combination with pharmaceuticals or who deal with patients who've self-administered inappropriate herbs.

Herb-Drug Interactions in Oncology was created to provide science-based information for the medical community and the general public. Each herb or remedy description is accompanied by information as to its origin, most common uses, benefits and problems. The book provides detailed information on 140 remedies and describes its constituents, mechanisms of action, adverse reactions, pharmacokinetics, and contraindications. Information on each herb or other remedy was developed through careful and critical reviews of research conducted by experts in pharmacy, botanicals, and complementary therapies. Each herb or product is discussed by the following sections: common name, scientific name, key words, clinical summary, herbal constituents, warnings, mechanisms of action, usage, adverse reactions, drug interactions, dosage, literature summary and critique, references, and notes.