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This important publication addresses the interactions of proteins with nonspecific binding sites on DNA as they play critical roles in fundamental cellular processes such as transcription, DNA replication, and recombination. The book presents current reviews of the biochemistry of representative nonspecific DNA-protein systems, and of their physiological functions. It includes chapters on the techniques used to characterize the complexes, on their thermodynamic properties, and on the role of nonspecific binding as gene regulatory proteins search for specific target sites on the chromosome. Systems considered include the effects of nonspecific binding in regulation of the lactose operon of Escherichia coli, the T4 bacteriophage gene 32 protein, the E. coli single strand binding (SSB) protein and recA protein, eukaryotic SSB's and histone-DNA complexes. The book presents those proteins displaying multiple modes of DNA binding as participants in more than one cellular process. This monograph combines rigorous descriptions of new findings for these important systems with provocative interpretations of the biological significance of the results. It is of great value to researchers ranging from graduate students to senior scientists in the areas of biochemistry, microbiology and molecular/cell biology.

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The study of the interactions of proteins, whether they be enzymes, regulatory proteins or structural proteins, with nucleic acids is one of the most exciting areas of modern molecular biology. In this 1993 text, Professor Steitz reviews the wide-ranging research in structural studies of DNA-binding proteins and their complexes with DNA. The author clearly and concisely describes the uses of techniques in molecular genetics, DNA synthesis, protein crystallography and nuclear magnetic response. The book, by a now Nobel Prize-winning author, will continue to be enjoyed by anyone with an interest in this exciting area of research.

One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein-DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create unified view of the field and a fuller understanding of protein-DNA interactions.

This practical guide offers concise coverage of the scientific and pharmaceutical aspects of protein delivery from controlled release microparticulate systems-emphasizing protein stability during encapsulation and release.

Biotechnology and Biopharmaceuticals: Transforming Proteins and Genes into Drugs defines biotechnology from the perspective of pharmaceuticals. The first section focuses on the process of transforming a biologic macromolecule into a therapeutic agent, while the second section provides a brief overview of each class of macromolecule with respect to physiological role and clinical application. Additional detail is also provided in the second section for each FDA approved, recombinantly derived biopharmaceutical for each category of macromolecule. The final section looks to the future and the new advances that will enhance our ability to develop new macromolecules into effective biopharmaceuticals. This last section discusses various drug delivery strategies while also describing gene and cell therapy strategies.

Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Focuses on protein allostery in drug discoveryDraws together the study of protein structure/function and the study of allosteryContributed by experts in this field Dr. Jian Zhang is Professor at Shanghai Jiao Tong Univ.

The kidney plays a crucial role in the metabolism of many low molecular weight proteins. Many drugs and chemicals can injure the kidney and cause an increase in urinary proteins and enzymes. This publication reports the latest findings from experimental and clinical medicine on the renal handling of proteins and the nephrotoxicity of drugs and contrast media. Other areas of interest include renal physiology and pathophysiology, proteinuria, and the importance of urinary proteins and enzymes in the detection of kidney damage.

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Physicians have long known that many commonly used drugs affect the way the body processes certain foods and that foods in turn affect the action of drugs. Now Morgan, a professor at the Institute of Human Nutrition of Columbia University's College of Physicians and Surgeons, has prepared a unique guide to help the layperson understand the effects of prescription and nonprescription drugs on the body's nutritional status. The book contains alphabetically arranged entries describing more than 300 generic drugs (identified by brand name), action, side effects, foods to avoid while taking the drug, need for nutritional supplements, etc. Recommended for public libraries, general reference, and consumer health collections. Shirley Branden, formerly with Health Science Center Lib., Gainesville, Fla.Copyright 1986 Reed Business Information, Inc.

Useful for psychiatrists, residents, and medical students, this pocket (4.25x6.5<">) guide presents a broad view of pharmacokinetic drug interactions, and includes a separate guide with tables of drug interaction principles. For this second edition, material on phase I and phase II metabolism has been expanded, and there are new chapters on P-glycoproteins, minor P450 enzymes, and analgesics. Cozza is a psychiatrist affiliated with Walter Reed Army Medical Center. Annotation (c) Book News, Inc., Portland, OR (booknews.com)

As every healthcare provider knows, drug-drug interactions are as prevalent as they are preventable. The Clinical Manual of Drug Interaction Principles for Medical Practice is an exceptionally practical, thoroughly up-to-date resource to help psychiatric clinicians (including residents and nurses) understand and avoid potentially dangerous interactions and provide the highest standard of patient care. Many new medications have entered the market in recent years and knowledge of pharmacokinetics and pharmacogenetics has grown significantly. From earlier versions in concise guide format, the authors have evolved this new and enlarged Manual offering the expanded coverage and features that clinicians need to keep up with this critical field. Major sections cover metabolism (with new, expanded coverage of transporters); cytochrome P450 enzymes; up-to-date coverage of drug interactions by medical specialty; and practical matters, such as the medicolegal implications of drug-drug interactions and how to retrieve and review the literature. Each chapter includes extensive references and study cases to help the reader understand and contextualize the information. A summary table of drugs by specialty and their metabolic sites provides ready reference. The book s comprehensive coverage reflects the very latest research, and its user-friendly format will make it indispensable to anyone engaged in direct patient care.

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This book addresses the rise in patients use of herbal medications with traditional prescribed drugs by warning against combinations that may cause health problems. Over 1,000 references in books and medical journals given.

IF YOU DON’T KNOW THE POSSIBLE SIDE EFFECTS OF MIXING HERBS, DRUGS, AND VITAMINS, YOU’RE PUTTING YOURSELF AT RISK.Did you know that . . .Using echinacea to ward off a cold while you’re taking Tylenol can severely damage your liver?Mixing kava kava and alcohol can be toxic?If you’re diabetic and you take Panax ginseng, you can dangerously lower your blood sugar levels?Drinking green tea can lead to false-positive results for some forms of cancer?Taking St. John’s wort while you’re on birth control, prescription antidepressants, or certain heart medications can be deadly?These are just a few of the warnings you need to know. If you’re one of the 60 million herb, vitamin, and supplement users in America, you need to know how to use herbs and supplements safely and effectively. The Essential Herb-Drug-Vitamin Interaction Guide profiles 300 supplements and gives vital information regarding potentially dangerous interactions, possible side effects, and typical dosages.Written by a leading authority in the field and a veteran health writer, The Essential Herb-Drug-Vitamin Interaction Guide is organized alphabetically by herb, with an index of medications at the end of the book so you can instantly locate the information you need, Comprehensive, thoroughly researched, and easy to use, this is one health guide you can’t afford to be without.

Presenting detailed, evidence-based coverage of the most commonly encountered therapeutic agents in modern clinical practice, this resource is designed to help you safely and effectively integrate herbal, nutrient, and drug therapy for your patients or clients. Combining pharmaceuticals with herbs or supplements may complement or interfere with a drug’s therapeutic action or may increase adverse effects. Additionally, drug-induced depletion of nutrients can occur. Comprehensive clinical data, quick-reference features, and the insight and expertise of trusted authorities help you gain a confident understanding of how herbal remedies and nutritional supplements interact with pharmaceuticals and develop safe, individualized treatment strategies for your patients.More than 60 comprehensive monographs of herb-drug and nutrient-drug interactions cover the most commonly used herbs and nutrients in health-related practice and help you coordinate safe, reliable therapy.Each herb and nutrient monograph features summary tables and concise, practical suggestions that provide quick and easy reference and complement the systematic review and in-depth analysis.References included on the bound-in CD provide high-quality, evidence-based support.Unique icons throughout the text differentiate interactions, evidence, and clinical significance.Up-to-date information keeps you current with the latest developments in pharmacology, nutrition, phytotherapy, biochemistry, genomics, oncology, hematology, naturopathic medicine, Chinese medicine, and other fields.A diverse team of authoritative experts lends valuable, trans-disciplinary insight.

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This is a 287-page reference book for healthcare professionals that fits in a lab coat pocket. It is fully indexed and referenced and contains over 350 herbs with actual and potential interactions with hundreds of drugs. Contains a chart of interactions involving common herbs, the FDA list of herbs associated with illness and injuries, the GRAS list, herbs that decrease absorption of drugs, and drugs that may alter the effects of herbs.