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Since it was first identified in 2003, bisphosphonate-induced osteonecrosis has come under growing scrutiny by medical and dental specialists alike because it affects cancer patients receiving intravenous bisphosphonate therapy and osteoporosis patients receiving oral bisphosphonate therapy and yet its presentation of exposed bone is limited to the jaws. Based on a clear understanding of the disease mechanism and documented outcomes of the relatively small number of cases treated to date, this timely book presents definitive treatment protocols for patients who present at each stage in its progression. Equally important, it offers a simple method for predicting risk as well as crucial recommendations for steps that can be taken to prevent the disease from developing when bisphosphonate therapy is indicated. Finally, a series of comprehensive case histories related to both oral and intravenous bisphosphonates provide direct guidance in managing patients spanning the full presentation spectrum.Contents 1. Description and History of Bisphosphonate-Induced Osteonecrosis of the Jaws2. Modes of Action and Pharmacokinetics of the Bisphosphonate Family3. Medical Indications for Bisphosphonates4. Osteopetrosis: A Genetic Analogue to Bisphosphonate-Induced Osteonecrosis of the Jaws5. Risks, Prevention, and Management of Intravenous Bisphosphonate Induced Osteonecrosis of the Jaws6. Risks, Prevention, and Management of Oral Bisphosphonate Induced Osteonecrosis of the Jaws7. Clinical Pathologic Case SamplesGlossary

Since it was first identified in 2003, bisphosphonate-induced osteonecrosis has come under growing scrutiny by medical and dental specialists alike because it affects cancer patients receiving intravenous bisphosphonate therapy and osteoporosis patients receiving oral bisphosphonate therapy and yet its presentation of exposed bone is limited to the jaws. Based on a clear understanding of the disease mechanism and documented outcomes of the relatively small number of cases treated to date, this timely book presents definitive treatment protocols for patients who present at each stage in its progression. Equally important, it offers a simple method for predicting risk as well as crucial recommendations for steps that can be taken to prevent the disease from developing when bisphosphonate therapy is indicated. Finally, a series of comprehensive case histories related to both oral and intravenous bisphosphonates provide direct guidance in managing patients spanning the full presentation spectrum.Contents 1. Description and History of Bisphosphonate-Induced Osteonecrosis of the Jaws2. Modes of Action and Pharmacokinetics of the Bisphosphonate Family3. Medical Indications for Bisphosphonates4. Osteopetrosis: A Genetic Analogue to Bisphosphonate-Induced Osteonecrosis of the Jaws5. Risks, Prevention, and Management of Intravenous Bisphosphonate Induced Osteonecrosis of the Jaws6. Risks, Prevention, and Management of Oral Bisphosphonate Induced Osteonecrosis of the Jaws7. Clinical Pathologic Case SamplesGlossary

While many clinicians currently recognize that bisphosphonate usage is associated with osteonecrosis of the jaws, this book establishes the causal relationship between the two, explaining the biologic modes of action that enable bisphosphonates taken both orally and intravenously to induce osteonecrosis of the jaws. Like the first edition, it presents definitive treatment protocols for patients who present at each stage in the progression of osteonecrosis, but this new edition also includes a simplified staging system and information about the serum CTX test for oral bisphosphonate cases. In addition, several management principles and surgical techniques are provided, along with new data on osteopenia and osteoporosis, the conditions for which bisphosphonates are primarily prescribed. The book offers a simple method for predicting risk as well as crucial recommendations for preventing the disease from developing when bisphosphonate therapy is indicated. Comprehensive case histories related to both oral and intravenous bisphosphonates provide direct guidance in managing patients spanning the full presentation spectrum. A must-have for the student and practicing clinician alike.Contents1. Description and History of Bisphosphonate-Induced Osteonecrosis of the Jaws2. Modes of Action and Pharmacokinetics of the Bisphosphonate Family3. Medical Indications for Bisphosphonates4. Osteopetrosis: A Genetic Analogue to Bisphosphonate-Induced Osteonecrosis of the Jaws5. Risks, Prevention, and Management of Intravenous Bisphosphonate-Induced Osteonecrosis of the Jaws6. Risks, Prevention, and Management of Oral Bisphosphonate-Induced Osteonecrosis of the Jaws7. Clinical Pathologic Case Samples