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A foundation for quantitative perspectives and a framework for interpreting experimental observations. Researchers in the life sciences who are unaware of the origins of the fundamental concepts and theoretical constructs in ligand-receptor energetics may fail to recognize the hidden assumptions and premises in their interpretations of observed phenomena. This book offers a detailed exposition of these fundamentals and of the treatment of multiple equilibria in successive steps of the binding of ligands to receptors. It also describes the calculations and meanings of energetic quantities for ligand-receptor complexes. Ligand-Receptor Energetics is the only book on this topic that is both accessible to beginners and extremely useful for experienced investigators. It features numerous specific examples; tables of literature results; extensive, up-to-date thermodynamic data; graphical representations of ligand bonding concepts; and four helpful appendices. Topics covered include: * Affinities -from site, stoichiometric, and ghost-site perspectives * Facts and fantasies from graphical analyses * Numerical evaluation of stoichiometric binding constants * Affinity profiles * Thermodynamic perspectives * Forces of interaction * Molecular scenarios. This valuable supplementary text for students in all areas of the basic life sciences is also an excellent professional reference for researchers in biochemistry, molecular biology, physiology, biophysics, microbiology, neurobiology, immunology, pharmacology, endocrinology, and toxicology.

A digital copy of "Chemoattractant Ligands And Their Receptors" by Horuk. Download is immediately available upon purchase!

A foundation for quantitative perspectives and a framework for interpreting experimental observations. Researchers in the life sciences who are unaware of the origins of the fundamental concepts and theoretical constructs in ligand-receptor energetics may fail to recognize the hidden assumptions and premises in their interpretations of observed phenomena. This book offers a detailed exposition of these fundamentals and of the treatment of multiple equilibria in successive steps of the binding of ligands to receptors. It also describes the calculations and meanings of energetic quantities for ligand-receptor complexes. Ligand-Receptor Energetics is the only book on this topic that is both accessible to beginners and extremely useful for experienced investigators. It features numerous specific examples; tables of literature results; extensive, up-to-date thermodynamic data; graphical representations of ligand bonding concepts; and four helpful appendices. Topics covered include: * Affinities -from site, stoichiometric, and ghost-site perspectives * Facts and fantasies from graphical analyses * Numerical evaluation of stoichiometric binding constants * Affinity profiles * Thermodynamic perspectives * Forces of interaction * Molecular scenarios. This valuable supplementary text for students in all areas of the basic life sciences is also an excellent professional reference for researchers in biochemistry, molecular biology, physiology, biophysics, microbiology, neurobiology, immunology, pharmacology, endocrinology, and toxicology.

To appreciate the chemistry and physical properties of complexes of the transition series, an understanding of metal-ligand interactions applied to complexes of the d-block is needed. Metal Ligand Bonding aims to provide this through an accessible, detailed, non-mathematical approach. Initial chapters detail the crystal-field model, using it to describe the use of magnetic measurements to distinguish complexes with different electronic configurations and geometries. Subsequent chapters look at the molecular orbital theory of transition metal complexes using a pictorial approach. Bonding in octahedral complexes is explored and electronic spectra and magnetic properties are given extensive coverage. The material addressed in this book forms the foundation of undergraduate lecture courses on d-block chemistry and facilitates learning through various key features, including: full colour diagrams; in-text questions with answers; revision exercises and clearly defined learning outcomes to encourage a reflective approach to study; an associated website; and experimental data and observations from everyday life. A basic knowledge of atomic and molecular orbitals as applied to main group elements is assumed.

In this book, originally published in 1983, a synthesis of old and new notions straddling the disciplines of physics and chemistry is described; and this provides a means of exploiting ligan-field properties of transition-metal and lathanide complexes leading to a quantified chemical insight into the individual metal-ligand interactions in these molecular species. Electronic spectroscopy and the ESR technique are well documented, but there has long been a need for a thorough description of magnetochemistry. A major section of this book therefore provides a details account of the physics and chemistry of paramagnetism. The second main section is concerned with those aspects of ligand-field theory that are required to construct the working composite defining ligand-field analysis. Though the book is intended for the research chemist, the subject matter and level of some of the material is suitable for both advanced undergraduate and postgraduate chemists and solid-state physicists.

538p blue cloth, excellent condition, first edition, subject index, very good

Good condition. This is the average used book, that has all pages or leaves present, but may include writing. Book may be ex-library with stamps and stickers. 1.35

A digital copy of "Serotonin Receptors and Their Ligands" by Wijngaarden. Download is immediately available upon purchase!

Catalytic asymmetric synthesis has been one of the most active research areas in chemistry (Nobel Prize in 2001). The development of efficient chiral catalysts plays a crucial role in asymmetric catalysis. Although many chiral ligands/catalysts have been developed in the past decades, the most efficient catalysts are derived from a few core structures, called "privileged chiral catalysts". This ultimate "must have" and long awaited reference for every chemist working in the field of asymmetric catalysis starts with the core structure of the catalysts, explaining why a certain ligand or catalyst is so successful. It describes in detail the history, the basic structural characteristics, and the applications of these "privileged catalysts". This novel presentation provides readers with a much deeper insight into the topic and makes it a must-have for organic chemists, catalytic chemists, chemists working with/on organometallics, chemists in industry, and libraries. From the contents: * BINAP * Bisphosphacycles - From DuPhos and BPE to a Diverse Set of Broadly Applied Ligands * Josiphos Ligands: From Discovery to Technical Applications * Chiral Spiro Ligands * Chiral Bisoxazoline Ligands * PHOX Ligands * Chiral Salen Complexes * BINOL * TADDOLate Ligands * Cinchona Alkaloids * Proline Derivatives

A digital copy of "Metal-ligand Interactions" by Unknown. Download is immediately available upon purchase!

A digital copy of "Ligand Efficiency Indices For Drug Discovery: Towards An Atlas-guided P" by Abad-zapatero. Download is immediately available upon purchase!

This book is a practical guide to the preparation and use of immobilized affinity ligands for purification, catalysis, and analysis. Special emphasis is given to immunochemical techniques including antibody isolation, preparation of antibody fragments using immobilized enzymes, and immunoaffinity chromatography. The book provides easy-to-follow, well-tested protocols to allow the uninitiated to use these techniques to the maximum advantage with minimum hassle. In addition, it shows researchers how to save money by making their own optimized affinity supports.Matrix activation: Ligand immobilization, Binding and elution of target molecules, Enzyme catalysis on solid supports, Analytical affinity chromatography, Isolation/purification of antibodies, Preparation of antibody fragments, Immunoaffinity chromatography, Immobilization of nucleic acids, Use of immobilized ligands for removal of trace contaminantsPractical advice on choosing: Matrices, Spacers, Methods of activation and couplingBackground information and insights on: Affinity interactions, The ease and power of affinity chromatography, Attaching molecules to insoluble supports, Matrices currently in use, Over 20 methods of activation, Spacers, Extensive References

This book is a practical guide to the preparation and use of immobilized affinity ligands for purification, catalysis, and analysis. Special emphasis is given to immunochemical techniques including antibody isolation, preparation of antibody fragments using immobilized enzymes, and immunoaffinity chromatography. The book provides easy-to-follow, well-tested protocols to allow the uninitiated to use these techniques to the maximum advantage with minimum hassle. In addition, it shows researchers how to save money by making their own optimized affinity supports.Matrix activation: Ligand immobilization, Binding and elution of target molecules, Enzyme catalysis on solid supports, Analytical affinity chromatography, Isolation/purification of antibodies, Preparation of antibody fragments, Immunoaffinity chromatography, Immobilization of nucleic acids, Use of immobilized ligands for removal of trace contaminantsPractical advice on choosing: Matrices, Spacers, Methods of activation and couplingBackground information and insights on: Affinity interactions, The ease and power of affinity chromatography, Attaching molecules to insoluble supports, Matrices currently in use, Over 20 methods of activation, Spacers, Extensive References

A digital copy of "Ligands And Modifiers In Vitreous Materials: The Spectroscopy Of Conden" by Alfred. Download is immediately available upon purchase!

A digital copy of "DNA Interactions with Drugs and Other Small Ligands" by Marcio Santos Rocha. Download is immediately available upon purchase!

A digital copy of "Identification Of Ligand Binding Site And Protein-protein Interaction A" by Roterman-konie. Download is immediately available upon purchase!

A digital copy of "BLyS Ligands and Receptors" by Michael P. Cancro. Download is immediately available upon purchase!

A hand-inspected Used copy of "Ligand Field Theory and Its Applications" by Brian N. Figgis and Michael A. Hitchman. Ships directly from Textbooks.com

A digital copy of "Protein-Ligand Interactions" by Holger Gohlke. Download is immediately available upon purchase!

A digital copy of "Ligand Design For G Protein-coupled Receptors" by Rognan. Download is immediately available upon purchase!