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Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic bi

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Elevate your style with these Ch 0164S-003 59 - 19 - 135 Sun Donna Metallo sunglasses from Chloé. Crafted with metallo, these sunglasses are the perfect accessory to complete any outfit. Shop now and add a touch of sophistication to your look.

It's not just about listening to music; it's about experiencing it in its purest form. The Forza Metallo Wireless In-Ear Bluetooth Headphones with Mic, Silver, embody a fusion of stylish design and state-of-the-art technology, delivering an unparalleled audio journey. Crafted by the renowned V-Moda, these headphones are a testament to the brand's commitment to high-quality sound and durable construction.The sleek, CNC forged aircraft-grade metal housing encases a 5.8mm featherweight micro driver, meticulously engineered to produce balanced, vibrant bass, vivid mids, and vivacious, stress-free highs. This creates a vast 3D soundstage that brings your music to life, ensuring every note is heard in crystal-clear detail.Equipped with a Qualcomm chipset, the Forza Metallo Wireless headphones boast the highest-end aptX Audio Codec, enabling CD-quality wireless audio playback that satisfies even the most discerning audiophiles. The long-lasting battery ensures up to 10+ hours of uninterrupted music playback, complemented by ultra-fast charging for those on the go.Communication is seamless with the noise-suppressing dual mics and a 3-button remote. Special algorithms and a mic array deliver crystal-clear speech calls and accurate voice assistant recognition. Effortlessly control calls, summon your voice assistant, and manage volume with intuitive controls.The Titanium Traplock ergonomics present a design masterpiece, ensuring these headphones remain securely in place through any movement, at all angles. The detachable ActiveFlex sport fins, available in three sizes, offer ultimate stability, whether you're commuting or working out.For personalized comfort, the BLISS 3.0 fittings come in four sizes, providing excellent noise isolation and enabling vibrant bass for the best fit, stability, and sound. These headphones are built to last, having been rigorously tested beyond military-level quality MIL-STD-810G test standards to withstand high and low temperatures, humidity, and UV exposure.Stay connected with haptic vibration notifications for incoming calls, ensuring you're always aware without being tethered to your device. The V-Micro USB cable simplifies charging and connectivity, eliminating the need for special cables or dongles.For those who appreciate personalization, the patent-pending RemixRings allow you to customize your headphones with 3D printed caps, handcrafted in NYC and sculpted in Italy at the V-MODA Milano design studio. These commissioned works of art elevate the Forza Metallo Wireless to the pinnacle of bespoke luxury, akin to a high-end watch or custom ring.In summary, the Forza Metallo Wireless In-Ear Bluetooth Headphones with Mic, Silver, offer a harmonious blend of advanced technology, robust durability, and elegant style, making them the perfect choice for anyone seeking a premium audio experience with the convenience of wireless freedom.

Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic bi

Mayhem in Metropolis! Superman seeks Batman's help as a giant metallic monster destroys downtown. Together, can the world's finest heroes take down Metallo and save the City of Tomorrow?

In-Ear. Hi-Res Audio. 3D Custom. Metal Active Headphones.

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Discover the stylish Oliver Peoples sunglasses crafted with metallo fabric. Elevate your accessory game with these chic shades.

Elevate your style with the 1186S Sole sungles from Oliver Peoples. These sleek metallo frames are the perfect acry for any outfit.

Introducing the stylish Versace Glasses, a must-have accessory for fashion-forward individuals. Crafted with high-quality metallo, these glasses exude elegance and sophistication. Elevate your look with these iconic Versace frames that effortlessly blend fashion and functionality.

Introducing the Cartier Sunglasses, a must-have accessory for the fashion-forward. Crafted with precision using high-quality metallo, these sunglasses exude elegance and style. Elevate your look with these iconic shades from Cartier.