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The present volume is the third volume of a projected four-volume series. This volume contains the following chapters: ."The Synthesis and Reactions of Pyrrole, Pyrazole, Triazole, Indole, Indazole, and Benzotriazole Nucleosides and Nucleotides," "The Synthesis, Reactions, and Properties of the 2'(3')-O-Aminoacyl and Peptidyl Nucleosides and Nucleotides," "Syntheses and Reactions of Bicyclic Heterocyclic Nucleosides and Nucleotides," "The Synthesis and Chemistry of Imidazole and Benzimidazole Nucleosides and Nucleotides," and "The Chemistry of C-Nucleosides." Each chapter is comprehensive in nature and should provide a ready reference source for not only the novice but also the experienced investiga tor or researcher. The chapters have been prepared by authors with considerable experience in each particular area of research, and this has resulted in a lucid presentation of each well-defined area. These volumes (1-3) were designed with medicinal chemists, medicinal organic chemists, organic chemists, carbohydrate chemists, physical chemists, and biological chemists in mind. However, because of the tremendous recent interest in this research area owing to the biological and chemotherapeutic evaluation ofnucleosides and nucleotides as anticancer, antiviral, and antiparasitic agents, these volumes should also be valuable additions to the libraries of virologists, biochemical phar­ macologists, oncologists, and pharmacologists. We would like to thank the authors for their enthusiasm and help in making these volumes available to the scientific community.

The present volume is the third volume of a projected four-volume series. This volume contains the following chapters: ."The Synthesis and Reactions of Pyrrole, Pyrazole, Triazole, Indole, Indazole, and Benzotriazole Nucleosides and Nucleotides," "The Synthesis, Reactions, and Properties of the 2'(3')-O-Aminoacyl and Peptidyl Nucleosides and Nucleotides," "Syntheses and Reactions of Bicyclic Heterocyclic Nucleosides and Nucleotides," "The Synthesis and Chemistry of Imidazole and Benzimidazole Nucleosides and Nucleotides," and "The Chemistry of C-Nucleosides." Each chapter is comprehensive in nature and should provide a ready reference source for not only the novice but also the experienced investiga tor or researcher. The chapters have been prepared by authors with considerable experience in each particular area of research, and this has resulted in a lucid presentation of each well-defined area. These volumes (1-3) were designed with medicinal chemists, medicinal organic chemists, organic chemists, carbohydrate chemists, physical chemists, and biological chemists in mind. However, because of the tremendous recent interest in this research area owing to the biological and chemotherapeutic evaluation ofnucleosides and nucleotides as anticancer, antiviral, and antiparasitic agents, these volumes should also be valuable additions to the libraries of virologists, biochemical phar­ macologists, oncologists, and pharmacologists. We would like to thank the authors for their enthusiasm and help in making these volumes available to the scientific community.

Assembling the work of an international panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments, the book highlights the most popular ionization methods and illustrates the diversity of strategies employed in the characterization and sequencing of DNA and RNA oligomers, nucleosides, nucleotides, and adducts. It describes studies performed on deoxyinosine and its analogues and provides an introduction to tandem mass spectrometry (MS/MS).Next, the contributors examine mass spectrometric application in the study of cyclic nucleotides in biochemical signal transduction. They analyze urinary modified nucleosides and explore DNA adducts. They discuss isotope labeling of DNA-mass spectrometry (ILD-MS) and examine various uses of electrospray ionization mass spectrometry (ESI-MS). The book reviews recent progress in the direct MS characterization of noncovalent nucleic acid-protein complexes, explores the interaction and ionization of guanidine-derived compounds with highly acidic biomolecules, and examines quantitative identification of nucleic acids via signature digestion products detected using mass spectrometry.The book describes a direct-infusion ESI-MS approach that can serve as a screening technique for the presence of modified nucleosides from small RNAs. Lastly, it discusses the LC-MS/MS method for the in vitro replication studies on damage-containing DNA substrates, and concludes with an examination of the influence of metal ions on the structure and reactivity of nucleic acids.The exciting developments in mass spectrometry technology have fueled incredible advances in our understanding of nucleic acids and their complexes. The contributions presented in this volume capture the range of these advances, helping to inspire new findings a

Assembling the work of an international panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments, the book highlights the most popular ionization methods and illustrates the diversity of strategies employed in the characterization and sequencing of DNA and RNA oligomers, nucleosides, nucleotides, and adducts. It describes studies performed on deoxyinosine and its analogues and provides an introduction to tandem mass spectrometry (MS/MS).Next, the contributors examine mass spectrometric application in the study of cyclic nucleotides in biochemical signal transduction. They analyze urinary modified nucleosides and explore DNA adducts. They discuss isotope labeling of DNA-mass spectrometry (ILD-MS) and examine various uses of electrospray ionization mass spectrometry (ESI-MS). The book reviews recent progress in the direct MS characterization of noncovalent nucleic acid-protein complexes, explores the interaction and ionization of guanidine-derived compounds with highly acidic biomolecules, and examines quantitative identification of nucleic acids via signature digestion products detected using mass spectrometry.The book describes a direct-infusion ESI-MS approach that can serve as a screening technique for the presence of modified nucleosides from small RNAs. Lastly, it discusses the LC-MS/MS method for the in vitro replication studies on damage-containing DNA substrates, and concludes with an examination of the influence of metal ions on the structure and reactivity of nucleic acids.The exciting developments in mass spectrometry technology have fueled incredible advances in our understanding of nucleic acids and their complexes. The contributions presented in this volume capture the range of these advances, helping to inspire new findings a