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One of the pathways by which the scientific community confirms the validity of a new scientific discovery is by repeating the research that produced it. When a scientific effort fails to independently confirm the computations or results of a previous study, some fear that it may be a symptom of a lack of rigor in science, while others argue that such an observed inconsistency can be an important precursor to new discovery. Concerns about reproducibility and replicability have been expressed in both scientific and popular media. As these concerns came to light, Congress requested that the National Academies of Sciences, Engineering, and Medicine conduct a study to assess the extent of issues related to reproducibility and replicability and to offer recommendations for improving rigor and transparency in scientific research. Reproducibility and Replicability in Science defines reproducibility and replicability and examines the factors that may lead to non-reproducibility and non-replicability in research. Unlike the typical expectation of reproducibility between two computations, expectations about replicability are more nuanced, and in some cases a lack of replicability can aid the process of scientific discovery. This report provides recommendations to researchers, academic institutions, journals, and funders on steps they can take to improve reproducibility and replicability in science. Table of ContentsFront MatterExecutive SummarySummary1 Introduction2 Scientific Methods and Knowledge3 Understanding Reproducibility and Replicability4 Reproducibility5 Replicability6 Improving Reproducibility and Replicability7 Confidence in ScienceReferencesAppendix A: Biographical Sketches of Committee Members and StaffAppendix B: Agendas of Open Committee MeetingsAppendix C: Recommendations Grouped by StakeholderAppendix D: Using Bayes Analysis for Hypothesis TestingAppendix E: Conducting Replicable Surveys of Scientific Communities

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Defense of Scientific Hypothesis: From Reproducibility Crisis to Big Data sets out to explain and defend the scientific hypothesis. Alger's mission is to counteract the misinformation and misunderstanding about the hypothesis that even seasoned scientists have concerning its nature and place in modern science. Most biological scientists receive little or no formal training in scientific thinking. Further, the hypothesis is under attack by critics who claim that it is irrelevant to science. In order to appreciate and evaluate scientific controversies like global climate change, vaccine safety, etc., the public first needs to understand the hypothesis. Defense of Scientific Hypothesis begins by describing and analyzing the scientific hypothesis in depth and examining its relationships to various kinds of science. Alger then guides readers through a review of the hypothesis in the context of the Reproducibility Crisis and presents survey data on how scientists perceive and employ hypotheses. He assesses cognitive factors that influence our ability to use the hypothesis and makes practical and policy recommendations for teaching and learning about it. Finally, Alger considers two possible futures of the hypothesis in science as the Big Data revolution looms: in one scenario, the hypothesis is displaced by the Big Data Mindset that forgoes understanding in favor of correlation and prediction. In the other, robotic science incorporates the hypotheses into mechanized laboratories guided by artificial intelligence. But in his illuminating epilogue, Alger envisions a third way, the Centaur Scientist, a symbiotic relationship between human scientists and computers.

Benjamin’s famous “Work of Art” essay sets out his boldest thoughts―on media and on culture in general―in their most realized form, while retaining an edge that gets under the skin of everyone who reads it. In this essay the visual arts of the machine age morph into literature and theory and then back again to images, gestures, and thought. This essay, however, is only the beginning of a vast collection of writings that the editors have assembled to demonstrate what was revolutionary about Benjamin’s explorations on media. Long before Marshall McLuhan, Benjamin saw that the way a bullet rips into its victim is exactly the way a movie or pop song lodges in the soul.This book contains the second, and most daring, of the four versions of the “Work of Art” essay―the one that addresses the utopian developments of the modern media. The collection tracks Benjamin’s observations on the media as they are revealed in essays on the production and reception of art; on film, radio, and photography; and on the modern transformations of literature and painting. The volume contains some of Benjamin’s best-known work alongside fascinating, little-known essays―some appearing for the first time in English. In the context of his passionate engagement with questions of aesthetics, the scope of Benjamin’s media theory can be fully appreciated.

Benjamin’s famous “Work of Art” essay sets out his boldest thoughts―on media and on culture in general―in their most realized form, while retaining an edge that gets under the skin of everyone who reads it. In this essay the visual arts of the machine age morph into literature and theory and then back again to images, gestures, and thought. This essay, however, is only the beginning of a vast collection of writings that the editors have assembled to demonstrate what was revolutionary about Benjamin’s explorations on media. Long before Marshall McLuhan, Benjamin saw that the way a bullet rips into its victim is exactly the way a movie or pop song lodges in the soul.This book contains the second, and most daring, of the four versions of the “Work of Art” essay―the one that addresses the utopian developments of the modern media. The collection tracks Benjamin’s observations on the media as they are revealed in essays on the production and reception of art; on film, radio, and photography; and on the modern transformations of literature and painting. The volume contains some of Benjamin’s best-known work alongside fascinating, little-known essays―some appearing for the first time in English. In the context of his passionate engagement with questions of aesthetics, the scope of Benjamin’s media theory can be fully appreciated.

The Sony MDR-MV1 offers extended spatial sound reproducibility and accurate sound object positioning within a 360-degree space, as well as clear, h...

Fine art quality, black-and-white prints are within every photographer's reach with the techniques illustrated in this digital image editing guide. Taking advantage of the control and reproducibility that the digital darkroom offers, this handbook teaches photographers how to fine-tune images with contrast and exposure levels, crop and rotate images for dynamic results, and remove flaws such as dust and scratches long after the photograph has been taken. Instruction on techniques that simulate traditional hand coloring and tinting and add special effects such as frames, infrared, and lighting and lens effects helps photographers realize their artistic vision. Screen shots and images guide readers through the presented techniques, allowing photographers to gauge their own results and anticipate the effects of the outlined corrections and enhancements on their own images. A gallery of the author's work provides inspiration for simulating—and improving upon—the chemical-based darkroom experience.

Analyzes construction of experiments, focusing on variables, models, matrices, and reproducibility.This timely reference systematically examines the basic concepts and theoretical issues, methodologies for experiment and measurement, and practical health applications of emulsions and dispersions-describing formulation problems and identifying potential carriers for the delivery or targeting of new drugs.Evaluates anionic, cationic, and nonionic surfactants as dispersing, emulsifying, foaming, penetrating, and wetting agents.Written by more than 20 international researchers, Pharmaceutical Emulsions and Suspensionsdiscusses uses of macroemulsions and (submicron) microemulsions illuminates delivery devices such as microparticles, nanospheres, liposomes, and mixed micelles investigates the application of self-emulsifying drug delivery systems (SEDDS) introduces techniques for increasing drug solubility with nanosuspensions addresses stabilization, flocculation, and coagulation problems in pharmaceutical and cosmetic suspensions surveys drug delivery by way of dermatological, follicular, and ocular routes explains the pharmacodynamics, bioavailability, and pharmacokinetics in the drug formulation development process compares and contrasts monomeric and micellar adsorption at oil-water interfaces and more!Containing over 1800 references, tables, equations, drawings, and micrographs, Pharmaceutical Emulsions and Suspensions is an ideal resource for pharmacists; physical, surface, colloid, cosmetic, food, and agricultural chemists; and upper-level undergraduate and graduate students in these disciplines.

Analyzes construction of experiments, focusing on variables, models, matrices, and reproducibility.This timely reference systematically examines the basic concepts and theoretical issues, methodologies for experiment and measurement, and practical health applications of emulsions and dispersions-describing formulation problems and identifying potential carriers for the delivery or targeting of new drugs.Evaluates anionic, cationic, and nonionic surfactants as dispersing, emulsifying, foaming, penetrating, and wetting agents.Written by more than 20 international researchers, Pharmaceutical Emulsions and Suspensionsdiscusses uses of macroemulsions and (submicron) microemulsions illuminates delivery devices such as microparticles, nanospheres, liposomes, and mixed micelles investigates the application of self-emulsifying drug delivery systems (SEDDS) introduces techniques for increasing drug solubility with nanosuspensions addresses stabilization, flocculation, and coagulation problems in pharmaceutical and cosmetic suspensions surveys drug delivery by way of dermatological, follicular, and ocular routes explains the pharmacodynamics, bioavailability, and pharmacokinetics in the drug formulation development process compares and contrasts monomeric and micellar adsorption at oil-water interfaces and more!Containing over 1800 references, tables, equations, drawings, and micrographs, Pharmaceutical Emulsions and Suspensions is an ideal resource for pharmacists; physical, surface, colloid, cosmetic, food, and agricultural chemists; and upper-level undergraduate and graduate students in these disciplines.

John Sinclair and a panel of expert investigators present a comprehensive collection of cellular and molecular techniques for the analysis of cytomegalovirus (CMV) biology and its pathogenetic mechanisms. The methods-all described in step-by-step detail with ready reproducibility in mind-range from basic virus culture to complex molecular analysis of CMV structure and function. Included are methods for CMV detection using both immunological and biological techniques, methods for analyzing fundamental aspects of the CMV infection cycle, and methods for analyzing T cell response to cytomegalovirus infection in the human host. Comprehensive and state-of-the-art, Cytomegalovirus Protocols provides investigators with a collection of the key methods that are illuminating not only the basic biology of this complex and intriguing human herpesvirus, but also its significant role in human infectious diseases and their emergent therapies.

Defense of Scientific Hypothesis: From Reproducibility Crisis to Big Data sets out to explain and defend the scientific hypothesis. Alger's mission is to counteract the misinformation and misunderstanding about the hypothesis that even seasoned scientists have concerning its nature and place in modern science. Most biological scientists receive little or no formal training in scientific thinking. Further, the hypothesis is under attack by critics who claim that it is irrelevant to science. In order to appreciate and evaluate scientific controversies like global climate change, vaccine safety, etc., the public first needs to understand the hypothesis. Defense of Scientific Hypothesis begins by describing and analyzing the scientific hypothesis in depth and examining its relationships to various kinds of science. Alger then guides readers through a review of the hypothesis in the context of the Reproducibility Crisis and presents survey data on how scientists perceive and employ hypotheses. He assesses cognitive factors that influence our ability to use the hypothesis and makes practical and policy recommendations for teaching and learning about it. Finally, Alger considers two possible futures of the hypothesis in science as the Big Data revolution looms: in one scenario, the hypothesis is displaced by the Big Data Mindset that forgoes understanding in favor of correlation and prediction. In the other, robotic science incorporates the hypotheses into mechanized laboratories guided by artificial intelligence. But in his illuminating epilogue, Alger envisions a third way, the Centaur Scientist, a symbiotic relationship between human scientists and computers.

TOPS Learning Systems, Weighing 05. This book is about science ownership. Students improvise a serviceable and sensitive gram balance that supports all TOPS activities requiring weight measure. The physics of balance equilibrium, centering, sensitivity, restoring forces, reproducibility, trueness, mass vs. weight, all get real on instruments that students build themselves.

John Sinclair and a panel of expert investigators present a comprehensive collection of cellular and molecular techniques for the analysis of cytomegalovirus (CMV) biology and its pathogenetic mechanisms. The methods-all described in step-by-step detail with ready reproducibility in mind-range from basic virus culture to complex molecular analysis of CMV structure and function. Included are methods for CMV detection using both immunological and biological techniques, methods for analyzing fundamental aspects of the CMV infection cycle, and methods for analyzing T cell response to cytomegalovirus infection in the human host. Comprehensive and state-of-the-art, Cytomegalovirus Protocols provides investigators with a collection of the key methods that are illuminating not only the basic biology of this complex and intriguing human herpesvirus, but also its significant role in human infectious diseases and their emergent therapies.