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Since the publication of the Third Series atlas on heart tumors, there have been several changes in the pathology and classification of these lesions. The current edition updates the status of heart tumors, with emphasis on newer findings, especially molecular advances. In most cases, the authors have followed the classification of the World Health Organization, whose updated volume on tumors of the lung, heart, and mediastinum is forthcoming. Because newer imaging modalities, especially cardiac magnetic resonance imaging and 3-D echocardiography are increasingly utilized in preoperative evaluation of heart tumors, the authors have introduced a chapter devoted exclusively to radiologic diagnosis. In addition, inflammatory myofibroblastic tumor, a less common tumor of heart valves, is covered quite differently from the previous volume, since several reports and series of this childhood tumor have emerged. This atlas has carried over a discussion of lesions that are neither neoplastic no

This volume builds upon the work of its predecessor in the third series of the Atlas of Tumor Pathology, liberally illustrating the spectrum of each tumor and disease described, while providing many new illustrations. Morphometry, flow cytometry, immunohistochemistry, gene rearrangement studies, and other molecular biologic methodologies are exciting new areas that are being developed into diagnostic procedures in the pathology laboratory. Where these methodologies are applicable to salivary gland disease, they are included. Histomorphologic evaluation, however, remains the principal and most useful method for diagnosis of salivary gland tumors and is the emphasis of this Fascicle. A differential diagnosis is included in the discussion of most tumors, and the cytopathologic features of those tumors most commonly encountered in the cytopathology laboratory are discussed.

Tumors in Domestic Animals, Fifth Edition is a fully revised new edition of the most comprehensive and authoritative reference on veterinary tumor pathology in common domestic animals, now in full color throughout with the most current advances in research and diagnostics. Now in full color with hundreds of exquisite new images showing diagnostic features, pathogenesis, and techniques Adds new sections on relevant clinical pathology and oncology Updated throughout to include the very latest advances in research and diagnostics Takes a logical, user-friendly system approach Written by leading experts on animal tumor pathology

The pituitary gland is the "master gland" that regulates many of the functions of other endocrine glands and their target tissues throughout the body. There is virtually no organ or tissue that is not affected, directly or indirectly, by the hormones that are secreted by the anterior and posterior pituitary. Pituitary dysfunction is a common clinical scenario. However, the manifestations of pituitary disease vary from florid clinical features that can readily be identified and recognized as pituitary in etiology, to more subtle and nonspecific problems that are often overlooked or misdiagnosed, leaving the relationship to pituitary malfunction unnoticed. The former¬--conditions such as florid acromegaly and Cushing's disease--are only a minority of pituitary pathologies, hence the misconception that pituitary disease is rare. The most common disorder is the pituitary adenoma, a lesion that is increasingly recognized as a highly prevalent finding identified in up to 20% of the population. Although many of these are considered to be incidental findings, many have unrecognized impact on fertility, longevity and quality of life, and their clinical significance is increasingly gaining attention. Moreover, the management of these lesions has seen major changes with the development of new pharmacotherapeutic agents, improved minimally invasive surgical approaches and targeted radiotherapeutic techniques. There has been significant progress in understanding pituitary development, physiology and pathology. The classification of pituitary disease is becoming easier, and as targeted therapies are being developed, the role of the pathologist in determining accurate diagnoses is increasingly important. The surgical pathologist must therefore recognize the important role of morphologic analysis in classifying sellar pathology for the diagnosis and management of the pituitary patient.

Tumors in Domestic Animals, Fifth Edition is a fully revised new edition of the most comprehensive and authoritative reference on veterinary tumor pathology in common domestic animals, now in full color throughout with the most current advances in research and diagnostics. Now in full color with hundreds of exquisite new images showing diagnostic features, pathogenesis, and techniques Adds new sections on relevant clinical pathology and oncology Updated throughout to include the very latest advances in research and diagnostics Takes a logical, user-friendly system approach Written by leading experts on animal tumor pathology

This book covers all liver tumors and lesions that clinically and radiologically mimic liver tumors. It provides readers with a comprehensive overview of this complex and rapidly evolving field. All aspects of surgical pathology are addressed, supplemented by detailed presentations of the lesions’ cell-biologic and molecular features. In addition, the methods employed for diagnosis and diagnostic algorithms are discussed. It appeals to pathologists and hepatologists and serves as an invaluable aid to diagnosis.The field of liver tumors and tumor-like lesions in adults and children has experienced tremendous advances in recent years. Specifically, the recognition of novel entities, deepened insights into known tumors, and refinement of classifications have necessitated continual updates and reappraisals. In addition, previous understanding of hepatic carcinogenesis and tumor progression has been transformed by the very rapid evolution of our understanding of cell biology, genomics, signaling pathways, cell interactions, and mechanisms of invasion and spread of hepatic tumor cells. These general pathology issues must be combined with surgical pathology if a comprehensive understanding of liver tumor pathology is to be achieved.

Since the third edition of Tumors of Domestic Animals there has been an enormous expansion of our knowledge about the melocular mechanisms of tumor development and the ancillary aids used diagnose neoplasms . The fourth edition condenses this new body of information and presents it in a way that is useful to diagnostic pathologists, residents, veterinarians, and oncologists. The format of the previous editions has been maintained, but the text and the illustrations are substantially changed or entirely different. Readers will be able to find salient clinical information, prevalence data, biological behavior, and most importantly, accurate information about gross and microscopic lesions to help diagnostic pathologists establish an accurate morphological diagnosis. The editor and authors of Tumors of Domestic Animals,all recognized experts in their fields, recognize the need for accurate morpological diagnoses in veterinary patient care, particularly with the numerous treatment modalities now available to oncologists and owners. This landmark reference in veterinary pathology provides the applicable information that clinical veterinarians need and want to make decisions about treatment of the animals in their care.

This volume builds upon the work of its predecessor in the third series of the Atlas of Tumor Pathology, liberally illustrating the spectrum of each tumor and disease described, while providing many new illustrations. Morphometry, flow cytometry, immunohistochemistry, gene rearrangement studies, and other molecular biologic methodologies are exciting new areas that are being developed into diagnostic procedures in the pathology laboratory. Where these methodologies are applicable to salivary gland disease, they are included. Histomorphologic evaluation, however, remains the principal and most useful method for diagnosis of salivary gland tumors and is the emphasis of this Fascicle. A differential diagnosis is included in the discussion of most tumors, and the cytopathologic features of those tumors most commonly encountered in the cytopathology laboratory are discussed.

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AFIP Atlas: Tumors of the Bone Marrow Evolution in the field of diagnostic hematopathology has been remarkable. The World Health Organization (WHO) classification scheme for hematologic neoplasms has achieved widespread endorsement and acceptance in clinical practice. This volume integrates proposed WHO 2016 recommendations and highlights areas in which further classification revisions may occur, or areas in which criteria are controversial. In addition, the immunophenotypic and molecular genetic tests of greatest value in diagnoses, risk assessment, and disease monitoring are highlighted in this text. The substantial focus on molecular genetic findings for each neoplasm parallels the ever-expanding role of genetics in disease classification and risk assessment. Key problem areas and differential diagnostic considerations are also included for each neoplastic disease category. Although primary blood and bone marrow neoplasms are the focus of this text, metastatic neoplasms in bone marr

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The current incarnation of this Fascicle builds on its predecessors and is meant to serve as an up-to-date text-rich atlas of tumors involving the upper aerodigestive tract and ear. Emphasis in the current work remains focused on light microscopy, but ancillary diagnostic techniques, including electron microscopy, immunohistochemistry, and molecular diagnostics, are presented in detail where appropriate. This volume will undoubtedly serve as an invaluable diagnostic reference for years to come.

When a specimen representing a tumor or tumor-like lesion of the eye or ocular adnexa is received in most general surgical pathology laboratories, the immediate reaction is one of panic, because these tumors are rarely encountered and often require complex gross dissections, based on a knowledge of ocular anatomy, which most general surgical pathologists either never possessed or have long since forgotten. Drs. Font, Croxatto, and Rao state that their main objective is to emphasize the important features of these lesions that are of special interest to general and surgical pathologists. In addition to providing complete descriptions of the tumors and tumor-like lesions in the various compartments of the eye and ocular adnexa, the authors correlate the pathologic features with epidemiologic and pathogenetic observations, clinical features, differential diagnosis, and special studies including immunohistochemistry and various molecular approaches. Each anatomic site has a section on normal anatomy and histology, and there is a separate chapter on the pathologic examination of ocular specimens, so that the general pathologist can approach these uncommonly encountered specimens with confidence. Because of its scholarly, practical, well illustrated and well referenced approach, this work will appeal to pathologists and ophthalmologists alike.

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