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Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic bi

Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic bi

Book is in Used-VeryGood condition. Pages and cover are clean and intact. Used items may not include supplementary materials such as CDs or access codes. May show signs of minor shelf wear and contain very limited notes and highlighting. 1.8

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Canada's drug laws are constantly changing. But what does Canada's history of drug prohibition say about its future? Busted is an illustrated history of Canadian drug prohibition and resistance to that prohibition. Reproducing over 170 archival and contemporary drawings, paintings, photographs, film stills and official documents from the 1700s to the present, Susan Boyd shows how Canada's drug prohibition policies evolved and were shaped by race, class and gender discrimination. This history demonstrates that prohibition and criminalization produces harm rather than benefits. Visually engaging and approachably written, Busted is a timely examination of Canada's history of drug control and movements against that control. Susan Boyd argues that in order to chart the future, it is worthwhile for us as Canadians to know our history of prohibition.

Canada's drug laws are constantly changing. But what does Canada's history of drug prohibition say about its future? Busted is an illustrated history of Canadian drug prohibition and resistance to that prohibition. Reproducing over 170 archival and contemporary drawings, paintings, photographs, film stills and official documents from the 1700s to the present, Susan Boyd shows how Canada's drug prohibition policies evolved and were shaped by race, class and gender discrimination. This history demonstrates that prohibition and criminalization produces harm rather than benefits. Visually engaging and approachably written, Busted is a timely examination of Canada's history of drug control and movements against that control. Susan Boyd argues that in order to chart the future, it is worthwhile for us as Canadians to know our history of prohibition.

This is a comprehensive tool covering all manifestations of antimicrobial resistance, with viral, bacterial, parasitical and fungal resistance each given a dedicated section. The underlining molecular mechanisms, which depend not only on the microbe, but on the specific drug (target), are highly diverse, and are covered in great detail. This work also discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.

The portals are everywhere, now. Scanning for weapons, for drugs. ... No getting out of line. The people had forgotten how to fight back. There was no one to show them how. Or was there ... ? When she first saw him he was silhouetted against the moon, a black stallion rearing up to claim all he surveyed. Her heart slowed in her chest, then. There was a strange keening in her ears that she knew was not of this time or place, but of the other world. It was a vision she was having, a waking dream that would haunt her, drive her in ways unexplained. In the dark of the city's night, wherever the weak or oppressed cry out in pain or fear, a quiet footfall can be heard on the roof, the owlshadow passeth before the moon, the quiet gasp of feathered death ... The Black Arrow lives.

A comprehensive account of the structural classes of antibiotics that have impacted human infectious disease. · Provides an introduction to antibiotics and examines how antibiotics block specific proteins acting in essential bacterial processes and how the molecular structure of the small-molecule drugs enables their antibiotic activity. · Explores the development of bacterial resistance to antibiotics, including the molecular logic that microbial producers of antibiotics use for self-protection. · Addresses the molecular logic of antibiotic biosynthesis, starting with regulatory networks that control gene transcription of secondary metabolites in streptomycetes, and examines the prospects for broadening the base of bacterial targets and also where new antibiotics are likely to emerge, including both synthetic chemical efforts and natural products.

The year is 2140. Peter and Anna are living freely on the Outside, trying hard to lead normal lives, but unable to leave the terror of the Declaration--and their experiences as surpluses--completely behind them. Peter is determined to infiltrate Pharma Corporation, which claims to have a new drug in the works; "Longevity +" will not just stop the ravages of old age, it might just reverse the aging process. But what Peter and Anna discover behind the walls of Pharma is so nightmarish it makes the prison of their childhood seem like a sanctuary: for it seems the only way to regain youth is to harvest the young.

A growing number of adolescents arrive in the therapist's office beyond adult control. Their behavior is outrageous, they use drugs heavily, and their moods fluctuate wildly. Nothing seems to work. If they stay in treatment, they make a shambles of the process. If they terminate prematurely, therapists may feel they never really got hold of the case; worse, they are not sure how they could have done so. Therapists looking at their interactions with patients will usually notice distinct patterns. The out-of-control patient usually shows a preference for one of five pathological patterns: narcissism, masochism, the paranoid stance, the schizoid defense, and affective lability. This book studies the five patterns of interaction typical of out-of-control adolescents, showing therapists how to recognize each and introducing interventions to interrupt them. When patients are forced into new, less comfortable experiences of themselves and their therapists, more honest exchanges become possible and more conventional treatment approaches become feasible.

This is a comprehensive tool covering all manifestations of antimicrobial resistance, with viral, bacterial, parasitical and fungal resistance each given a dedicated section. The underlining molecular mechanisms, which depend not only on the microbe, but on the specific drug (target), are highly diverse, and are covered in great detail. This work also discusses and compares the biological, biochemical and structural aspects of resistance and its evolution.

Ciudad Juárez has recently become infamous for its murder rate, which topped 3,000 in 2010 as competing drug cartels grew increasingly violent and the military responded with violence as well. Despite the atmosphere of intimidation by troops, police, and organized criminals, women have led the way in civil society activism, spurring the Juárez Resistance and forging powerful alliances with anti-militarization activists. An in-depth examination of la Resistencia Juarense, Courage, Resistance, and Women in Ciudad Juárez draws on ethnographic research to analyze the resistance's focus on violence against women, as well as its clash with the war against drugs championed by Mexican President Felipe Calderón with the support of the United States. Through grounded insights, the authors trace the transformation of hidden discourses into public discourses that openly challenge the militarized border regimes. The authors also explore the advocacy carried on by social media, faith-based organizations, and peace-and-justice activist Javier Sicilia while Calderón faced U.S. political schisms over the role of border trade in this global manufacturing site. Bringing to light on-the-ground strategies as well as current theories from the fields of sociology, political anthropology, and human rights, this illuminating study is particularly significant because of its emphasis on the role of women in local and transnational attempts to extinguish a hot zone. As they overcome intimidation to become game-changing activists, the figures featured in Courage, Resistance, and Women in Ciudad Juárez offer the possibility of peace and justice in the wake of seemingly irreconcilable conflict.

Covers the discovery, development, use and potential use, and regulation of plant-derived drugs. Describes ongoing research for prospective natural drugs with anticancer and anti-infective activities. Features some highly promising compounds, including artemisinin, camptothecin, forskolin, and taxol. Includes coverage of biologically active constituents of terrestrial and marine plants. Also addresses the effects of the destruction of rain forests on drug discovery.

Haley gathers 12 medical outsiders' stories to support his theory that the AMA, FDA, and big pharmaceutical companies conspire to prevent new ideas from entering medical research and practice. His subjects include Andrew Ivy, who advocated the discredited anticancer drug Krebiozen; anticancer herbalist Harry Hoxsey; anticancer blood researcher Gaston Naessens; and antineoplastin researcher Stanislaw Burzynski. Those persecuted medical investigators are fairly well known, but some of Haley's other cases concern forgotten men like William Koch, developer of the antipolio drug Glyoxylide, whom many may find more interesting because of their obscurity. The stories of all 12 are often absent from current medical histories, which alone makes this book worthwhile. Haley's thesis that many of his subjects were victims of organized medicine, however, remains unproven. Moreover, his assertion that at least five of the 12 should have been Nobel laureates strains credibility, and the implication that the AMA controls the decisions of the Nobel committees seems dubious. --William Beatty, American Library Association.

No understanding of the history of the sixties could be complete without a grasp of the work of Leary, Alpert, and Metzner, the cultural resistance to their experiments, and the way in which psychoactive drug use became a part of contemporary society. Next Generation Independent Book Awards Finalist, Birth of a Psychedelic Culture explores these experiments and their cultural milieu through never before seen photographs, personal accounts of authors Ralph Metzner and Ram Dass, and conversations with luminaries such as Aldous Huxley, Charles Mingus, Allen Ginsberg, William Burroughs and others that appeared on the scene.

In the future a degenerate Western society becomes obssessed with an hallucinogenic drug, allowing the Chinese to take over Europe without any resistance

King studies how, in the cop action genre, working-class police officers weigh in on such topics as racial justice, homosexuality, misogyny, unemployment, worker resistance, affirmative action, drug use, poverty, divorce, and the use of violence to deal with social problems. Facing their enemies with wisecracks and firepower, these men prove themselves at once complicitous in a system of violence and corruption and worthy to "blow away," with neither hesitation nor remorse, their—and society's—menacing threats. The central male figures in these stories are heroes in their fight against criminals, but, as individuals, they feel undervalued by women, unappreciated by their bosses, and out of place in a society where fat cats and liberals have all the power. Such "hard times," King's study reveals, position them to simultaneously long for, disdain, and heroically—if violently—stake their frustrated claim to white male privilege. Discussing such topics as white male guilt and the rage of the oppressed and examining such films as Lethal Weapon, Die Hard, and Silence of the Lambs, King's book notes the socially-charged roles given to American culture's fictional police heroes. The last artisan in a culture that has become increasingly corporate and bureaucratized, the movie cop is the last 'real man' in a world that has emasculated men and the last non-conforming patriot in a world that pays more attention to rules than what is morally right. A book that shows how modern mythology makes sense of rampant corruption (and provides entertainment in its punishment), Heroes in Hard Times will educate and provoke those interested in American popular culture, film, and gender studies.

In the future a degenerate Western society becomes obssessed with an hallucinogenic drug, allowing the Chinese to take over Europe without any resistance

This is a standalone novel. New York Times bestselling book, The Resistance, is also a standalone. They share some of the same characters, but can be read separately. The Redemption - He was everything she never wanted. Yet, she couldn’t stop thinking about him. Soulful, amber eyes A sex, drugs, and rock n’roll reputation A body that beckoned for sin Three years ago Rochelle Floros was living her dream come true... then lost it all. On the worst day of her life, the last person she expected to be there for her was a rock star and tabloid favorite. Now, she’s trying to rebuild her life after the tragedy that destroyed her fairytale. Slowly, she found herself captivated by a sexy, bad boy drummer she had known for years. Rochelle was caught between the grief that shrouded her heart and the charismatic man that made it race. What she didn’t know is if he was being sincere or toying with her heart. The Redemption is about finding the pulse of your soul in the most unlikely places and giving love a chance to grow. Can what she wants really be what she needs? With his rhythm and her passion, can they make music together? Or will their harmony be lost forever?