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Like almost every major scientific or medical breakthrough in history, the transdermal delivery of drugs started as only an idea - slowly moving its way from the drawing board to actual testing and eventually approval. Today, there are more than 20 companies involved in transdermal drug delivery. In addition, almost every large pharmaceutical firm has ongoing transdermal delivery programs. But in spite of this effort and after 15 years from the introduction of the Nitroglycerin patch, only six transdermal drugs exist in the marketplace.The practice has been hampered by the fact that most drugs, as well as many excipients used in the manufacture of transdermal patches, cause skin irritation or skin sensitization. Similar problems exist with the application of dermatologicals and cosmetics to skin, which in many cases are equally as severe as those encountered in transdermal delivery.Biochemical Modulation of Skin Reactions: Transdermals, Topicals, Cosmetics presents a series of chapters describing technologies and the practical application of biochemicals which might lead to the reduction or abrogation of these skin reaction. In addition, it addresses those areas of skin immunology and skin sciences that account for the processes that control irritant and allergic contact dermatitis and outlines the numerous cellular and molecular factors involved in the development of irritation and sensitization.Indeed, Biochemical Modulation of Skin Reactions helps serve as a catalyst for further research in the field, allowing for more drugs and cosmetics to be applied to the skin without adverse effects.Features

Author's affiliation is not cited. Instructional manual of biochemical tests for identifying bacteria in the laboratory. This edition has been updated to include new nomenclature resulting from the significant advancements in the study of microorganisms. Abundant references. For students and professionals. Previous edition: c1980. Wire-spiral binding.

This classic text gives a uniquely lucid and lively view of neurotransmitters, their role in nervous system function, and their involvement in the mechanisms of psychiatric drug action. For three decades it has served as an essential guide for students of neuroscience and psychopharmacology, residents in psychiatry and neurology, and clinicians and scientists. Both authoritative and very readable, it has been thoroughly updated for each edition. In the Eighth Edition more space is devoted to clinical examples, subclasses of receptors that provide targets for new drugs, molecular genetics, the major problem of drug delivery to the brain, and the growing recognition of nicotinic receptors in the brain and their possible involvement in Alzheimer's and Parkinson's diseases. In addition, the book's format has been enlarged and a second color added to many of the illustrations.

Biochemical Pathways An Atlas of Biochemistry and Molecular Biology Edited by Gerhard Michal Modern biochemistry is a complex field, combining areas of cell biology, molecular biology, medicine, immunology, genetics-even neuroscience. Many of these disciplines converge in the dynamic arena of research dealing with metabolic processes and other mechanisms present at the cellular and molecular level. Biochemical Pathways offers a truly unique road map to modern biochemistry. In full and vivid color, it features detailed charts-each color-coded and accompanied by a brief explanation-of metabolic pathways and their relationship to regulation pathways. Important mechanisms of molecular biology are reviewed in the second part of the book. This encyclopedic compendium goes well beyond traditional biochemistry to cover some very specialized pathways and many aspects of regulation. The clear, systematic presentation includes: * Metabolic structures and reaction mechanisms * The intermediates and enzymes involved * Metabolic branching points * Transcription and translation * Signal transduction * Transport mechanisms * Blood coagulation, immunology, and the complement system Current, referenced, and easy-to-use, Biochemical Pathways is bound to become a classic in the field. It is a one-of-a-kind visual guide for researchers and scholars in all areas of the life sciences.

This classic text gives a uniquely lucid and lively view of neurotransmitters, their role in nervous system function, and their involvement in the mechanisms of psychiatric drug action. For three decades it has served as an essential guide for students of neuroscience and psychopharmacology, residents in psychiatry and neurology, and clinicians and scientists. Both authoritative and very readable, it has been thoroughly updated for each edition. In the Eighth Edition more space is devoted to clinical examples, subclasses of receptors that provide targets for new drugs, molecular genetics, the major problem of drug delivery to the brain, and the growing recognition of nicotinic receptors in the brain and their possible involvement in Alzheimer's and Parkinson's diseases. In addition, the book's format has been enlarged and a second color added to many of the illustrations.

An integrated approach to the study of drug action mechanisms Biochemical Pharmacology is a concise and contemporary textbook on the principles of drug action. It discusses representative drugs by example to explore the range of biochemical targets and mechanisms. The book explains some of the experiments that tell us how drugs work, and it outlines the physiological and pathological context that make those action mechanisms therapeutically useful. Biochemical Pharmacology is intended primarily for students in biology and biochemistry at the advanced undergraduate or graduate levels. For classroom use, the illustrations from the book are separately available as PowerPoint slides. It is written in a conversational, vivid style that readily encourages students to explore this important area of medical science. Biochemical Pharmacology can also serve as an introduction for professionals in biosciences, as well as in pharmaceutical and health sciences. Complete with numerous figures throughout the text, which are also available separately as PowerPoint slides, Biochemical Pharmacology: Explains the role of pharmacodynamics, pharmacokinetics, and drug metabolism in drug action Provides representative examples from the pharmacology of cell excitation, hormones, nitric oxide, chemotherapy, and others Examines emerging applications of ribonucleic acids as drugs and drug targets Discusses what researchers need to know about the problems of drug distribution, elimination, and toxicity Biochemical Pharmacology is an important resource for anyone wishing to gain an in-depth understanding of drug action mechanisms and extremely useful for researchers wishing to explore some of the unanswered questions .

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Completely revised, updated, and enlarged, this second edition now contains a subchapter on biorecognition assays, plus a chapter on bioprocess control added by the new co-author Jun-ichi Horiuchi, who is one of the leading experts in the field. The central theme of the textbook remains the application of chemical engineering principles to biological processes in general, demonstrating how a chemical engineer would address and solve problems. To create a logical and clear structure, the book is divided into three parts. The first deals with the basic concepts and principles of chemical engineering and can be read by those students with no prior knowledge of chemical engineering. The second part focuses on process aspects, such as heat and mass transfer, bioreactors, and separation methods. Finally, the third section describes practical aspects, including medical device production, downstream operations, and fermenter engineering. More than 40 exemplary solved exercises facilitate understanding of the complex engineering background, while self-study is supported by the inclusion of over 80 exercises at the end of each chapter, which are supplemented by the corresponding solutions. An excellent, comprehensive introduction to the principles of biochemical engineering.

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In addition to updating each chapter and including a new discussion of the gaseous neuromodulators nitric oxide and carbon monoxide, the authors have dropped a formerly featured chapter on metabolism in the CNS and incorporated most of this material into a new chapter on the genetic basis of neurological and psychiatric diseases. With the almost bi-weekly discovery of genes that appear to be involved in diseases of the nervous system, this area has the potential for providing a revolutionary kind of therapy, and it has been accorded greater attention. This versatile text continues to be the first choice for basic neuropharmacology and neuroscience courses in medical schools and at the undergraduate level, pharmacy schools, graduate pharmacology programs, and residency programs in psychiatry and neurology.

Author's affiliation is not cited. Instructional manual of biochemical tests for identifying bacteria in the laboratory. This edition has been updated to include new nomenclature resulting from the significant advancements in the study of microorganisms. Abundant references. For students and professionals. Previous edition: c1980. Wire-spiral binding.

New! This book is in the same immaculate condition as when it was published 4.7

This work provides comprehensive coverage of modern biochemical engineering, detailing the basic concepts underlying the behaviour of bioprocesses as well as advances in bioprocess and biochemical engineering science. It includes discussions of topics such as enzyme kinetics and biocatalysis, microbial growth and product formation, bioreactor design, transport in bioreactors, bioproduct recovery and bioprocess economics and design. A solutions manual is available to instructors only.

Book is in Used-VeryGood condition. Pages and cover are clean and intact. Used items may not include supplementary materials such as CDs or access codes. May show signs of minor shelf wear and contain very limited notes and highlighting. 3.35

Botanists and zoologists have recognized for centuries the specificity of various insects for plants, and entomolo­ gists have long been aware that insects defend themselves from predators by emitting repulsive odors. Only recently have chemists and biologists established a joint endeavor for studying the chemical relationships between plants and insects. The present symposium volume of the Phytochemical Society of North America's RECENT ADVANCES IN PHYTOCHEMISTRY consists of eight papers dealing with phytochemical relation­ ships between plants and their insect herbivores. The fifteenth P.S.N.A. annual symposium and meeting was held in August, 1975, on the campus of The University of South Florida, Tampa. The chemical defenses of apparent and unapparent plants were contrasted by Feeny. Rodreguiz and Levin illustrated parallel defense mechanisms of plants and insects and then Hendry, Kostelc, Hindenlang, Wichmann, Fix and Koreniowski discussed chemical messengers for both plants and insects. Subsequently Beck and Reese reviewed plant contributions to insect nutrition and metabolism. Indepth studies for the monarch butterfly-milkweed interaction were presented by Roeske, Seiber, Brower, and Moffitt and for the cotton boll weevil-cotton plant relationship by Hedin, Thompson, and Gueldner. In the latter portion of the symposium Rhoades and Cates presented a general theory concerning the coevolu­ tion of insects and plant antiherbivore chemistry.

In recent years, parasitologists have learned much about the way in which parasite biochemistry differs from that of free-living organisms. Inside the host, factors such as temperature, oxygen tension, carbon dioxide concentration and pH have important consequences for the biochemistry and physiology of the parasitic organism. Strong selection pressure therefore operates at all stages of a parasite's life cycle. The parasite's adaptational response to this pressure is the subject of this book.

Biochemical Engineering Fundamentals, 2/e, combines contemporary engineering science with relevant biological concepts in a comprehensive introduction to biochemical engineering. The biological background provided enables students to comprehend the major problems in biochemical engineering and formulate effective solutions.

All engineering disciplines have been developed from the basic sciences. Science gives us the information on the reasoning behind new product development, whereas engineering is the application of science to manufacture the product at the commercial level. Biological processes involve various biomolecules, which come from living sources. It is now possible to manipulate DNA to get the desired changes in biochemical processes. This book provides students the knowledge that will enable them to contribute in various professional fields, including bioprocess development, modeling and simulation, and environmental engineering. It includes the analysis of different upstream and downstream processes. The chapters are organized in broad engineering subdisciplines, such as mass and energy balances, reaction theory using both chemical and enzymatic reactions, microbial cell growth kinetics, transport phenomena, different control systems used in the fermentation industry, and case studies of some industrial fermentation processes. Each chapter begins with a fundamental explanation for general readers and ends with in-depth scientific details suitable for expert readers. The book also includes the solutions to about 100 problems.

This new "Science of Nutrition" text examines nutrients, their cellular functions, their metabolism in the human body, and the basis of their requirements. It focuses on the use of nutrients and how they metabolize across the molecular, cellular, tissue, organ, and whole-body levels.(Includes FREE online biannual nutrition newsletter)