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How do we know what role a particular gene has? How do some genes control the expression of others? How do genes interact to form gene networks? With its unique integration of genetics and molecular biology, Genetic Analysis probes fascinating questions such as these, detailing how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, the book goes on to explore the use of gene mutations and the analysis of gene expression and activity. A discussion of the genetic structure of natural populations follows, before the interaction of genes during suppression and epistasis, how we study gene networks, and personalized genomics are considered. Drawing on the latest experimental tools, including CRISPR-Cas9 genome editing, microarrays, RNAi screens, and bioinformatics approaches, Genetic Analysis provides a state-of-the-art review of the field, but in a truly student-friendly manner. It uses extended case studies and text boxes to augment the narrative, taking the reader right to the forefront of contemporary research, without losing its clarity of explanation and insight. We are in an age where, despite knowing so much about biological systems, we are just beginning to realise how much more there is still to understand. Genetic Analysis is the ideal guide to how we can use the awesome power of molecular genetics to further our understanding.

How do we know what role a particular gene has? How do some genes control the expression of others? How do genes interact to form gene networks? With its unique integration of genetics and molecular biology, Genetic Analysis probes fascinating questions such as these, detailing how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, the book goes on to explore the use of gene mutations and the analysis of gene expression and activity. A discussion of the genetic structure of natural populations follows, before the interaction of genes during suppression and epistasis, how we study gene networks, and personalized genomics are considered. Drawing on the latest experimental tools, including CRISPR-Cas9 genome editing, microarrays, RNAi screens, and bioinformatics approaches, Genetic Analysis provides a state-of-the-art review of the field, but in a truly student-friendly manner. It uses extended case studies and text boxes to augment the narrative, taking the reader right to the forefront of contemporary research, without losing its clarity of explanation and insight. We are in an age where, despite knowing so much about biological systems, we are just beginning to realise how much more there is still to understand. Genetic Analysis is the ideal guide to how we can use the awesome power of molecular genetics to further our understanding.

Genome Science is a textbook and laboratory manual for advanced secondary and post-secondary education. It combines approachable narrative with extensively tested lab exercises that illustrate key concepts of genome biology in humans, invertebrates, and plants. Eighteen labs, organized into four chapters, engage students with both bioinformatics exercises and in vitro experiments. Each chapter also includes an extensive introduction that provides an historical and conceptual framework. This modular structure offers many options for enhancing existing courses, starting new courses, or supporting student research projects. The book is complete with advice for instructors, laboratory planning guidelines, recipes for solutions, and answers to student questions.

Contains 42 seminal papers illustrating advances in cell biology, along with brief commentaries that place the papers in historical and intellectual context. All papers are studies of eukaryotes, and are grouped according to themes of genome organization and replication, transcription, nuclear envelope and nuclear import, mitosis and cell cycle control, cell membrane and extracellular matrix, protein synthesis and membrane traffic, and cytoskeleton. Lacks a subject index. Gall teaches embryology at the Carnegie Institution. McIntosh teaches cell biology at the University of Colorado. Annotation c. Book News, Inc., Portland, OR (booknews.com)

In eukaryotes many vital cellular functions like metabolism, motility, secretion, growth, differentiation are ultimately regulated by protein phosphorylation/dephosphorylation. Extracellular signals which trigger these changes control protein kinases and protein phosphatases. It is the aim of this volume to unveil signal networks which connect extracellular signals via second messengers with chages of the phosphorylation state of target proteins.

Although they comprise one of the three fundamental branches of life, it was only the last decade that Archaea were formally recognized as a group alongside Eukaryotes and Bacteria. Bacteria-like in that they are single celled organisms that lack a nucleus and intracellular organelles, the Arachaea also share a large gene set typical of eukaryotes, for making and repairing DNA, RNA and protien. More surprisingly, they only inhabit environments typical of the extremes of early earth--hot springs, thermal ocean vents, saline lake, or oxygen deficient sediments. A breakpoint on the common evolutionary path, it is evident that the Archaea diverged early in the history of life, establishing thier importance in evolutionary sciences. Archaea: Ancient Microbes, Extreme Environments, and the Origin of Life tells this evolving story, furthering our understanding of the microbe commonalities, and providing for evolutionary justification in the use of archaea as mechanistic model systems.Provides a unique and current summary of common subcellular mechanisms in archaea and eukaryotesEmphasizes the use of genomics to provide a biological context for understanding archaeaContrasts evolutionary studies on the fossil record with those on molecular phylogenyIncludes extensive tables, graphs, images, drawings and other illustrationsSimplifies the interdisciplinary challenge necessary to understand the significance of archaea

An extension of the 1986 edition to include higher organisms, focusing on how an organism uses its genes to direct its growth. New chapters assess how well the lambda model can explain gene control in eukaryotes, and the elaborations necessary to explain more complex systems. Annotation copyright Book News, Inc. Portland, Or.

Parasitic Diseases 4th ed. is intended as a textbook for 2nd yr. medical students. It is fully illustrated in color and contains over 1,700 references to the original literature. Chapters deal with all major eukaryotes that cause disease in humans. In addition, three chapters deal with anti-parasitic drugs, medical ecology, and travel medicine in the tropics. It has become the standard text on the subject at most medical schools throughout the USA.

In eukaryotes many vital cellular functions like metabolism, motility, secretion, growth, differentiation are ultimately regulated by protein phosphorylation/dephosphorylation. Extracellular signals which trigger these changes control protein kinases and protein phosphatases. It is the aim of this volume to unveil signal networks which connect extracellular signals via second messengers with chages of the phosphorylation state of target proteins.

Parasitic Diseases 4th ed. is intended as a textbook for 2nd yr. medical students. It is fully illustrated in color and contains over 1,700 references to the original literature. Chapters deal with all major eukaryotes that cause disease in humans. In addition, three chapters deal with anti-parasitic drugs, medical ecology, and travel medicine in the tropics. It has become the standard text on the subject at most medical schools throughout the USA.

Fungi have their own unique cell biology and life cycle, but also play critical roles in wider biological systems. This textbook provides a comprehensive view of fungal biology, ranging in scope from the evolutionary origins of fungi and other eukaryotes more than a billion years ago, to the impact fungi have on everyday life. Bringing mycology teaching right up to date, this unique systems biology approach emphasises the interactions between fungi and other organisms to illustrate the critical roles that fungi play in every ecosystem and food web. With more than 60 colour figures, examples of computational modelling and resource boxes directing students to areas of interest online, this book gives students an appreciation of fungi both at the organism level and in the context of wider biology. A companion CD accompanying the print book features a hyperlinked version of the book and the fully integrated World of Cyberfungi website.

Throughout the natural world, organisms have responded to predators, inadequate resources, or inclement conditions by forming ongoing mutually beneficial partnerships--or symbioses--with different species. Symbiosis is the foundation for major evolutionary events, such as the emergence of eukaryotes and plant eating among vertebrates, and is also a crucial factor in shaping many ecological communities. The Symbiotic Habit provides an accessible and authoritative introduction to symbiosis, describing how symbioses are established, function, and persist in evolutionary and ecological time. Angela Douglas explains the evolutionary origins and development of symbiosis, and illustrates the principles of symbiosis using a variety of examples of symbiotic relationships as well as nonsymbiotic ones, such as parasitic or fleeting mutualistic associations. Although the reciprocal exchange of benefit is the key feature of symbioses, the benefits are often costly to provide, causing conflict among the partners. Douglas shows how these conflicts can be managed by a single controlling organism that may selectively reward cooperative partners, control partner transmission, and employ recognition mechanisms that discriminate between beneficial and potentially harmful or ineffective partners.The Symbiotic Habit reveals the broad uniformity of symbiotic process across many different symbioses among organisms with diverse evolutionary histories, and demonstrates how symbioses can be used to manage ecosystems, enhance food production, and promote human health.

Throughout the natural world, organisms have responded to predators, inadequate resources, or inclement conditions by forming ongoing mutually beneficial partnerships--or symbioses--with different species. Symbiosis is the foundation for major evolutionary events, such as the emergence of eukaryotes and plant eating among vertebrates, and is also a crucial factor in shaping many ecological communities. The Symbiotic Habit provides an accessible and authoritative introduction to symbiosis, describing how symbioses are established, function, and persist in evolutionary and ecological time. Angela Douglas explains the evolutionary origins and development of symbiosis, and illustrates the principles of symbiosis using a variety of examples of symbiotic relationships as well as nonsymbiotic ones, such as parasitic or fleeting mutualistic associations. Although the reciprocal exchange of benefit is the key feature of symbioses, the benefits are often costly to provide, causing conflict among the partners. Douglas shows how these conflicts can be managed by a single controlling organism that may selectively reward cooperative partners, control partner transmission, and employ recognition mechanisms that discriminate between beneficial and potentially harmful or ineffective partners.The Symbiotic Habit reveals the broad uniformity of symbiotic process across many different symbioses among organisms with diverse evolutionary histories, and demonstrates how symbioses can be used to manage ecosystems, enhance food production, and promote human health.

Contains 42 seminal papers illustrating advances in cell biology, along with brief commentaries that place the papers in historical and intellectual context. All papers are studies of eukaryotes, and are grouped according to themes of genome organization and replication, transcription, nuclear envelope and nuclear import, mitosis and cell cycle control, cell membrane and extracellular matrix, protein synthesis and membrane traffic, and cytoskeleton. Lacks a subject index. Gall teaches embryology at the Carnegie Institution. McIntosh teaches cell biology at the University of Colorado. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Although they comprise one of the three fundamental branches of life, it was only the last decade that Archaea were formally recognized as a group alongside Eukaryotes and Bacteria. Bacteria-like in that they are single celled organisms that lack a nucleus and intracellular organelles, the Arachaea also share a large gene set typical of eukaryotes, for making and repairing DNA, RNA and protien. More surprisingly, they only inhabit environments typical of the extremes of early earth--hot springs, thermal ocean vents, saline lake, or oxygen deficient sediments. A breakpoint on the common evolutionary path, it is evident that the Archaea diverged early in the history of life, establishing thier importance in evolutionary sciences. Archaea: Ancient Microbes, Extreme Environments, and the Origin of Life tells this evolving story, furthering our understanding of the microbe commonalities, and providing for evolutionary justification in the use of archaea as mechanistic model systems.Provides a unique and current summary of common subcellular mechanisms in archaea and eukaryotesEmphasizes the use of genomics to provide a biological context for understanding archaeaContrasts evolutionary studies on the fossil record with those on molecular phylogenyIncludes extensive tables, graphs, images, drawings and other illustrationsSimplifies the interdisciplinary challenge necessary to understand the significance of archaea

This novel text provides a concise synthesis of how the interactions between mitochondrial and nuclear genes have played a major role in shaping the ecology and evolution of eukaryotes. The foundation for this new focus on mitonuclear interactions originated from research in biochemistry and cell biology laboratories, although the broader ecological and evolutionary implications have yet to be fully explored. The imperative for mitonuclear coadaptation is proposed to be a major selective force in the evolution of sexual reproduction and two mating types in eukaryotes, in the formation of species, in the evolution of ornaments and sexual selection, in the process of adaptation, and in the evolution of senescence. The book highlights the importance of mitonuclear coadaptation to the evolution of complex life and champions mitonuclear ecology as an important subdiscipline in ecology and evolution.

The purpose of this book is to account for the structure and function of genes in terms of extensive knowledge about both prokaryotes and eukaryotes. It explains what a gene is, how it is reproduced and what controls its expression. This new edition has completely new chapters on protein trafficking and eukaryotic gene transcription. It has a new introduction to the subject, making the book more approachable to less advanced students. Chapters on bacterial transcriptions, post-transcriptional control, interrupted gene structure, RNA splicing, transposons in bacteria, transposable elements in eukaryotes, gene expression in development, and the role of oncogenes in carcinogenesis have been completely rewritten.

This novel text provides a concise synthesis of how the interactions between mitochondrial and nuclear genes have played a major role in shaping the ecology and evolution of eukaryotes. The foundation for this new focus on mitonuclear interactions originated from research in biochemistry and cell biology laboratories, although the broader ecological and evolutionary implications have yet to be fully explored. The imperative for mitonuclear coadaptation is proposed to be a major selective force in the evolution of sexual reproduction and two mating types in eukaryotes, in the formation of species, in the evolution of ornaments and sexual selection, in the process of adaptation, and in the evolution of senescence. The book highlights the importance of mitonuclear coadaptation to the evolution of complex life and champions mitonuclear ecology as an important subdiscipline in ecology and evolution.