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Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic bi

With genetic engineering, systems explored in this book now exist allowing for the simple, efficient, and near universally precise genetic manipulation directly in any organism, including the mouse. Herein, these models are applied to a wide field of disease areas, including diabetes, cardiovascular disease, skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinal disorders, as well as various behavioral models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, Mouse Models for Drug Discovery: Methods and Protocols, Second Edition serves to equip the reader with an extensive overview of techniques to utilize the many possibilities of mice in the drug development process.

Ben Hartman is vacationing in Zurich, Switzerland when he chances upon his old friend Jimmy Cavanaugh―a madman who's armed and programmed to assassinate. In a matter of minutes, six innocent bystanders are dead. So is Cavanaugh. But when his body vanishes, and his weapon mysteriously appears in Hartman's luggage, Hartman is plunged into an unfathomable nightmare...Meanwhile, Anna Navarro, field agent for the Department of Justice, has been asked to investigate the sudden, random deaths of eleven men throughout the world. The only thing that connects them? A secret file, over a half-century old, that's linked to the CIA―and is marked with the same puzzling codename: Sigma.As Anna follows the connecting thread―and Hartman finds himself on the run―she ends up in the shadows of a relentless killer who is one step ahead of her...victim by victim. Now, she and Hartman together must uncover the diabolical secrets long held behind Sigma. It will threaten everything they think they know about themselves―and confirm their very worst fears...

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NEW FROM THE AUTHOR OF WHITE PLAGUEMarine doctor and bio-terror expert Joe Rush returns in an electrifying new arctic adventure... "sure to wow fans of Michael Crichton and James Rollins" (Mark Greaney, #1 New York Times bestselling author of Tom Clancy Full Force and Effect).  When authorities in Alaska receive a disturbing call from a teenage girl, their investigation leads them to discover an entire family of researchers dead. Joe Rush is called to help examine the bodies. On the surface, it looks like a brutal murder/suicide. But the situation is nowhere near that simple—nor is it over.   Upon closer investigation, Rush discovers the terrifying truth. The research team has fallen victim to something that seems impossible at first, yet the evidence looks undeniable in the lab. Now the danger may threaten thousands more.   Unfortunately, he’s not the only one with knowledge of the looming disaster. The army has cordoned off part of Alaska, and Rush soon finds himself the target of trained killers. Someone suspects Rush of betraying his country. To save countless lives—starting with his own—Rush must uncover the answers hidden in the Arctic. The question is—will he find them in time?

Ex-library paperback with stickers and labels. Appears lightly used. All items ship Monday - Saturday - Fast Shipping in a secure package. Your purchase will help support the programs and collections of the Johnson County (Kansas) Library.

Although psychoanalytic theory is one of the most potent and influential tools in contemporary literary criticism, to date it has had very little impact on the study of African American literature. Critical methods from the disciplines of history, sociology, and cultural studies have dominated work in the field. Now, in this exciting new book by the author of Domestic Allegories: The Black Heroine's Text at the Turn of the Century, Claudia Tate demonstrates that psychoanalytic paradigms can produce rich and compelling readings of African American textuality. With clear and accessible summaries of key concepts in Freud, Lacan, and Klein, as well as deft reference to the work of contemporary psychoanalytic critics of literature, Tate explores African- American desire, alienation, and subjectivity in neglected novels by Emma Kelley, W.E.B. Du Bois, Richard Wright, Zora Neale Hurston, and Nella Larsen. Her pioneering approach highlights African American textual realms within and beyond those inscribing racial oppression and modes of black resistance. A superb introduction to psychoanalytic theory and its applications for African American literature and culture, this book creates a sophisticated critical model of black subjectivity and desire for use in the study of African American texts.

Paris 1956. Three nations collude to start a war. Their conspiracy is threatened when French journalist, Brigitte Friang, unearths a lost document - The Protocol of Sèvres. The contents of the document are so incredible that nobody will believe it until it happens.Brigitte is torn between her allegiance to her country and her obligation to reveal the truth. Within days of uncovering the secret plan, she finds herself in the middle of a war she could have prevented. A war that will endanger millions including the two men she loves.World leaders collide as the plan unfolds. Alliances are strained to the brink. Will events spin out of control and start World War III?Sèvres Protocol is an international political thriller ripped from the pages of history. Based on a true story with twists and turns that will keep you glued until the very last page. Pick up your copy today!

Harold Bloom is America's most esteemed literary critic and one of the greatest critical minds of our time. This work contains the best of Bloom's writing on the greatest novels and novelists of our time - from Daniel Defoe to Philip Roth, from Charles Dickens to Amy Tan. It also features his overview of the genre and thoughts on its development.

An exploration of the complex roles that bodies--both literally and figuratively--play in the 21 volume Aubrey-Maturin series reveals much about the novels' many meditations on mind and body. Beginning with a consideration of genre norms and the bodies of the novels' main characters, the book's focus shifts to the ways the series offers interconnections between the human body and history. More literal considerations of the body examine O'Brian's depictions of drug use, particularly the opium addiction that afflicts Stephen Maturin, and human sexuality in its many guises. The work then focuses on Desolation Island, the fifth novel in the series, in light of the discussions above but also in terms of political and psychological tropes that draw upon the relationship of mind and body. Questions are examined about the relationship of reader to author, and what sustains such a long narrative and what continues to bring a reader back again and again.

An exploration of the complex roles that bodies--both literally and figuratively--play in the 21 volume Aubrey-Maturin series reveals much about the novels' many meditations on mind and body. Beginning with a consideration of genre norms and the bodies of the novels' main characters, the book's focus shifts to the ways the series offers interconnections between the human body and history. More literal considerations of the body examine O'Brian's depictions of drug use, particularly the opium addiction that afflicts Stephen Maturin, and human sexuality in its many guises. The work then focuses on Desolation Island, the fifth novel in the series, in light of the discussions above but also in terms of political and psychological tropes that draw upon the relationship of mind and body. Questions are examined about the relationship of reader to author, and what sustains such a long narrative and what continues to bring a reader back again and again.

Famed international man and #1 bestselling author Doug Casey—in collaboration with John Hunt—releases DRUG LORD, Book 2 of the High Ground Novels. Charles Knight returns to the United States after seven years traveling the world. He embarks on two concurrent professions: one as a major investor in a small pharmaceutical company, and the other as the head of a black market drug-smuggling and -distribution operation. Charles has to sort through the legal and illegal, moral and immoral, and right and wrong as he navigates the War on Drugs and the crony pharmaceutical industry. Meet Tristana Dubocher—CEO of Charles’s company (Visioryme Pharmaceuticals)—and her sniveling husband, Donald, an FDA minion. Meet Seth Fowler of the DEA, whose criminality is exceeded only by his quest for power. Get to know Rainbow, a teenage girl living on the street who runs drugs for the Alphabet Men. Their careers in the drug world are forever altered when they meet Charles. Most importantly, meet Naked Emperor, a street drug that doesn’t cloud minds, but clears them. Naked Emperor prevents people from being able to lie to themselves. Anyone dependent on deception knows that this new drug will turn the world against them. Mobs of politicians, environmentalists, academics, tele-evangelists, jihadists, journalists, central bankers, Deep State actors, and crony parasites join forces to wipe Naked Emperor off the face of the planet. They all want him dead. But Charles Knight intends to start a revolution.

This Tip, Substance Abuse Treatment for Persons With Co-Occurring Disorders, revises Tip 9, Assessment and Treatment of Patients With Coexisting Mental Illness and Alcohol and Other Drug Abuse. The revised Tip provides information about new developments in the rapidly growing field of co-occurring substance use and mental disorders and captures the state-ofthe- art in the treatment of people with co-occurring disorders. The Tip focuses on what the substance abuse treatment clinician needs to know and provides that information in an accessible manner. The Tip synthesizes knowledge and grounds it in the practical realities of clinical cases and real situations so the reader will come away with increased knowledge, encouragement, and resourcefulness in working with clients with co-occurring disorders.

This completely revised and reformatted third edition is full of examples of the professional way to prepare and submit manuscripts for books novels series short stories articles verse and proposals of all types. Learn how to do query cover and business letters news releases affidavits bios publicity photos and much more. It is full of tips for writers and gives insider information.

An integrative approach to healing chronic autoimmune conditions by a doctor, researcher, and sufferer of progressive multiple sclerosis (MS) whose TEDx talk is already a web sensation Like many physicians, Dr. Terry Wahls focused on treating her patients’ ailments with drugs or surgical procedures—until she was diagnosed with multiple sclerosis (MS) in 2000. Within three years, her back and stomach muscles had weakened to the point where she needed a tilt-recline wheelchair. Conventional medical treatments were failing her, and she feared that she would be bedridden for the rest of her life. Dr. Wahls began studying the latest research on autoimmune disease and brain biology, and decided to get her vitamins, minerals, antioxidants, and essential fatty acids from the food she ate rather than pills and supplements. Dr. Wahl’s adopted the nutrient-rich paleo diet, gradually refining and integrating it into a regimen of neuromuscular stimulation. First, she walked slowly, then steadily, and then she biked eighteen miles in a single day. In November 2011, Dr. Wahls shared her remarkable recovery in a TEDx talk that immediately went viral. Now, in The Wahls Protocol, she shares the details of the protocol that allowed her to reverse many of her symptoms, get back to her life, and embark on a new mission: to share the Wahls Protocol with others suffering from the ravages of multiple sclerosis and other autoimmune conditions.

Here’s how hundreds of thousands have overcome chronic pain, chronic fatigue, obesity, insomnia, fibromyalgia, drug addiction, and many other toxin-induced inflammatory diseases! Thousands more use this method to prevent physically and financially devastating medical conditions altogether. Dr. David E. Root pioneered the niacin, exercise, and sauna therapy to treat workplace chemical and radiation exposure injuries back in 1982, and his 35 years’ experience and research have been well documented in peer-reviewed articles and even medical text books. In 2017 Dr. Root and his son, Daniel Root, released their 2-week health and wellness Detoxination® Protocol to the public. By harnessing a unique property of niacin, fat-stored toxins are mobilized and then eliminated via sebaceous sweat from sauna. This must-read, self-help guide will give you easy to follow step-by-step instructions on the only known safe and effective path to sustainable health so you can feel better, have more energy, sleep soundly, look younger, think more clearly, and much more!

This fully-updated book provides systems-based methodologies and innovative technologies that can be used for solving complicated problems of complex systems. A wide range of theoretical and experimental approaches are introduced for practical applications, as the content explores the basic and novel concepts in psychoneuroimmunology (PNI), especially the relationships among stress, inflammation, and psychophysiological disorders, as well as various cutting-edge technologies and methods for PNI studies, including the utilizations of mouse models and vaccine models. In addition, this book focuses on translational medicine by applying PNI methods in clinical practice. As part of the Methods in Molecular Biology series, the chapters seek to provide a practical, state-of-the-art, and holistic view for the translation of PNI into better preventive and personalized medical practice. Authoritative and hands-on, Psychoneuroimmunology: Methods and Protocols, Second Edition will be of use to biomedical students and professionals at all levels who are interested in integrative studies in psychology, psychiatry, neuroscience, immunology, molecular biology, genetics, bioengineering, physiology, pathology, microbiology, systems biology, and clinical medicine.

A work more disturbing than fiction from "the father of graphic novels" (The New York Times). "The ultimate illustration of how absurdly comical and cancerous The Protocols has been to mankind."–Thane Rosenbaum, Los Angeles Times Book ReviewThe Plot, which examines the astonishing conspiracy and the fabrication of The Protocols of the Elders of Zion, has become a worldwide phenomenon since its hardcover publication, taught in classrooms around the globe. Purported to be the actual blueprints by Jewish leaders to take over the world, the Protocols, first published in 1902, have become gospel truth to international millions. Presenting a pageant of historical figures from nineteenth-century Russia to today's ideologues, including Tsar Nicholas II, Henry Ford, and Adolf Hitler, Will Eisner unravels and dispels one of the most devastating hoaxes of the twentieth century.