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Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modeling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. In stressing the need for a quantitative understanding of how receptor-mediated cell functions depend on receptor and ligand properties, the book offers comprehensive treatments of both basic and state-of-the-art model frameworks that span the entire spectrum of receptor processes--from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioral functions they govern, including proliferation, adhesion, and migration. The book emphasizes mechanistic models that are accessible to experimental testing and includes detailed examples of important contemporary issues. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. As such, chemical engineers, researchers, and advanced students in the fields of biotechnology, biomedical sciences, bioengineering, and molecular cell biology will find this book to be conceptually rich, timely, and useful.

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Jones Stephens has built its reputation over the years as a leader in the plumbing industry, providing the market with thousands of products to complete any project. If you need it, we got it. The Shower Stall Drain with Receptor Base fits over 2 in. Schedule 40 DWV pipe. It includes a 4-1/4 in. round strainer. This drain allows for secondary drainage and accepts a knockout test cap for testing. Color: Polished Brass. Material: PVC.

Jones Stephens has built its reputation over the years as a leader in the plumbing industry, providing the market with thousands of products to complete any project. If you need it, we got it. The Shower Stall Drain with Receptor Base fits over 2 in. Schedule 40 DWV pipe. It includes a 4-1/4 in. round strainer. This drain allows for secondary drainage and accepts a knockout test cap for testing. Color: Satin Nickel. Material: PVC.

Muse Receptor 1.0 REV. C works very well. Boots from internal hard drive with no problems. Yes, it still has software & samples on it but I can...

Very good condition. Power switch is stuck on the "on" position.

There are many books that highlight the need and importance of mission toward unreached people. Unfortunately, few of them deal with the importance of understanding the real life of unreached people and how to analyze them.   This book identifies conceptual issues for the development of receptor-oriented communication strategies among young, educated, urban Hui (YEU-Hui) Muslims in China's northwestern cities in order to achieve culturally relevant churches in those areas. It is written to help not only those who are interested in the unreached, but also those who are interested in Muslim evangelism, urban sociology, biblical exegesis, contextual church planting, communication, and mission strategy.   Enoch Jinsik Kim utilizes a new approach--virtual community mission for planting offline churches--that integrates the use of local church-driven Internet community, traditional media, and offline task teams from a multi-ethnic local church. While the research focuses on the Chinese Muslim context, the identification of the young, urban, and educated as a strategic group for mission can be applied in other Muslim and non-Muslim contexts. This research is useful to cross-cultural communicators, church planters, and all those interested in interpersonal relationships.

There are many books that highlight the need and importance of mission toward unreached people. Unfortunately, few of them deal with the importance of understanding the real life of unreached people and how to analyze them.   This book identifies conceptual issues for the development of receptor-oriented communication strategies among young, educated, urban Hui (YEU-Hui) Muslims in China's northwestern cities in order to achieve culturally relevant churches in those areas. It is written to help not only those who are interested in the unreached, but also those who are interested in Muslim evangelism, urban sociology, biblical exegesis, contextual church planting, communication, and mission strategy.   Enoch Jinsik Kim utilizes a new approach--virtual community mission for planting offline churches--that integrates the use of local church-driven Internet community, traditional media, and offline task teams from a multi-ethnic local church. While the research focuses on the Chinese Muslim context, the identification of the young, urban, and educated as a strategic group for mission can be applied in other Muslim and non-Muslim contexts. This research is useful to cross-cultural communicators, church planters, and all those interested in interpersonal relationships.

Analyzes recent progress in mapping the brain and interpreting the functions of neurotransmitters, and discusses the implications of such innovations in terms of relieving mental illness and altering personality. 30,000 first printing. $30,000 ad/promo.

Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modeling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. In stressing the need for a quantitative understanding of how receptor-mediated cell functions depend on receptor and ligand properties, the book offers comprehensive treatments of both basic and state-of-the-art model frameworks that span the entire spectrum of receptor processes--from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioral functions they govern, including proliferation, adhesion, and migration. The book emphasizes mechanistic models that are accessible to experimental testing and includes detailed examples of important contemporary issues. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. As such, chemical engineers, researchers, and advanced students in the fields of biotechnology, biomedical sciences, bioengineering, and molecular cell biology will find this book to be conceptually rich, timely, and useful.

Receptors: Models for Binding, Trafficking, and Signaling bridges the gap between chemical engineering and cell biology by lucidly and practically demonstrating how a mathematical modeling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor/ligand interactions. In stressing the need for a quantitative understanding of how receptor-mediated cell functions depend on receptor and ligand properties, the book offers comprehensive treatments of both basic and state-of-the-art model frameworks that span the entire spectrum of receptor processes--from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioral functions they govern, including proliferation, adhesion, and migration. The book emphasizes mechanistic models that are accessible to experimental testing and includes detailed examples of important contemporary issues. This much-needed book introduces chemical engineers and bioengineers to important problems in receptor biology and familiarizes cell biologists with the insights that can be gained from engineering analysis and synthesis. As such, chemical engineers, researchers, and advanced students in the fields of biotechnology, biomedical sciences, bioengineering, and molecular cell biology will find this book to be conceptually rich, timely, and useful.

For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms, providing an integrated analysis of the mechanisms of drug action at membrane receptors. The hallmark of this popular text is the uniting of four major approaches to the study of receptors: Molecular investigation of receptor structure Quantitative functional studies of agonists and antagonists Ligand binding Signal transduction at the cell membrane Maintaining the second edition’s focus on cell membrane receptors and the immediate signal transduction events at the membrane, this edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions, giving students the ability to test their comprehension of the material. Hundreds of diagrams and figures further enhance the text. A time-saving resource and comprehensive learning tool, Textbook of Receptor Pharmacology, Third Edition carries on the tradition of providing in-depth, up-to-date coverage of this critical area that is both fundamental to the science of pharmacology and on the cutting edge of new drug development.

This authoritative and comprehensive volume presents a perspective in the molecular and cellular diversity of membrane ion channels. Written in an accessible format, it depicts the structure and function of each of the known classes of ion channels. Each chapter provides amino acid sequences, including data base accession numbers; views of secondary, tertiary and quaternary channel structure; and evolutionary relationships among channels.

New Book. Shipped from UK. Established seller since 2000.

Minor denting on spine. General shelf wear.

Ships from the UK. Former library book; may include library markings. Used book that is in clean, average condition without any missing pages.

Nicotine research has been conducted for the better part of a century, but with the discovery of the relationship of nicotinic systems to Alzheimer's disease, the differentiation of nicotinic receptor subtypes, and the development of novel nicotinic ligands, the field of nicotine research has exploded. This book will provide you reference to the latest research methods and findings concerning nicotinic neural systems.Featuring a unique approach, Nicotinic Receptors in the Nervous System provides integrated coverage of cutting-edge research concerning neuronal nicotinic systems relevant to smoking addiction and cognitive dysfunction. By bringing together molecular and neurochemical applications, this book provides the key to understanding function and dysfunction of nicotinic systems and how they are significant for disease, addiction, and the development of novel drug treatments. Within the next several years, it is very promising that clinical research will support the use of nicotinic treatments for addiction, pain, and cognitive and motor dysfunction. Nicotinic Receptors in the Nervous System provides you with the basic mechanistic background for these treatments as well as the functional assessment necessary to determine therapeutic effects.

A foundation for quantitative perspectives and a framework for interpreting experimental observations. Researchers in the life sciences who are unaware of the origins of the fundamental concepts and theoretical constructs in ligand-receptor energetics may fail to recognize the hidden assumptions and premises in their interpretations of observed phenomena. This book offers a detailed exposition of these fundamentals and of the treatment of multiple equilibria in successive steps of the binding of ligands to receptors. It also describes the calculations and meanings of energetic quantities for ligand-receptor complexes. Ligand-Receptor Energetics is the only book on this topic that is both accessible to beginners and extremely useful for experienced investigators. It features numerous specific examples; tables of literature results; extensive, up-to-date thermodynamic data; graphical representations of ligand bonding concepts; and four helpful appendices. Topics covered include: * Affinities -from site, stoichiometric, and ghost-site perspectives * Facts and fantasies from graphical analyses * Numerical evaluation of stoichiometric binding constants * Affinity profiles * Thermodynamic perspectives * Forces of interaction * Molecular scenarios. This valuable supplementary text for students in all areas of the basic life sciences is also an excellent professional reference for researchers in biochemistry, molecular biology, physiology, biophysics, microbiology, neurobiology, immunology, pharmacology, endocrinology, and toxicology.

The originality of this volume is to reveal to the reader the fascination of some unfamiliar sensory organs that are sometimes ignored and often misunderstood. These receptors have only recently been identified and their functional specificity is in some cases still a matter for discussion. The four classes of sensory organs considered here differ widely from one another in many respects. One might even say that the only thing they have in common is that they belong to cold-blooded vertebrates. These classes are: 1. the directionally sensitive lateral-line mechanoreceptors of fishes and amphi­ bians (Chapter 7); 2. the pseudobranchial organs of some teleosts, equipped with pressoreceptors and at least three other types of receptors (osmo- and chemoreceptors) (Chapter 8); 3. the infrared-sensitive pit organs of some snake families (Chapter 9) ; 4. the various kinds of electroreceptors found in several marine and freshwater fish families (Chapters 2 to 6). The first three classes of receptors mentioned above thus rate only one chapter each, whereas five chapters are devoted to the electroreceptors. Electroreception has aroused enormous interest among physiologists in specialties ranging from molecular biology to animal behavior. The resulting quantity of research and discussion fully justifies this disproportion. However, it cannot be denied that the contents of the volume must appear unbalanced and heterogeneous, yet it should not be perceived as a mere juxtaposition of particular and unrelated cases.

Intracellular Receptors: New Instruments for a Symphony of Signals In the late eighteenth century, it was proposed on theoretical grounds that each of the body's organs, beginning with the brain, must be "a factory and laboratory of a specific humor which it returns to the blood", and that these circulating signals "are indispensable for the life of the whole" (Bordeu 1775). During the nineteenth cen­ tury, some remarkable physiological experiments revealed the actions of humoral factors that affected the for and function of multiple tissues, organs and organ sys­ tems within the body (Berthold 1849); much later, the chemical and molecular na­ ture of some of those factors was determined. Against this deep historical backdrop of the founding studies of intercellular signaling, molecular biology sprang into existence a mere forty years ago, rooted in the revelation of regulable gene expression in bacteria. But contemporaneous with those classical analyses of transcriptional regulation of the lactose operon, the mod­ em era of signal transduction was inaugurated by the identification of cAMP as a second messenger --- an intracellular mediator of hormonal activation of glycogen catabolism (Sutherland and RaIl 1960). Later in that same decade, it emerged that cAMP is a critical signal not only in metazoans, but even in bacteria, where it serves an analogous function as a critical switch that activates expression of genes re­ quired for catabolism of complex carbon sources, including those of the lactose operon.